Tag Archive: pain



The last word for the over 40 on joint and tendon problems.com/watch?


Click here to watch video “DEATH BLOW to joint and tendon problems”

The number one reason why guys over 40 fail in their goals for shaping the body is simply because of excessive joint and tendons problems or pain. It becomes so bad that well, we either severely tone down our training or we stop all together. And there goes our dreams…

So, I’ve been faced with this dilemma as well…but man, I am NOT taking this lying down. I am a fighter that had to face death square in the eyes twice already. But I refuse to give up or go lie down and feel sorry for myself. I got up, faced life squarely in the eyes and then use my brain and wisdom to do research till my fingers were numb from typing. Through the wonder of internet I can trace the latest results-producing scientific research. Many of which is still in the final stages of approval with the FDA, which means it cannot yet be prescribed to you by your doctor. But the wonder is that most of these “grey” cutting edge products are easily available out there and not classified in the category of steroids which means it is fully legal at this stage.

But why would anyone want to put something into their body that is not yet FDA approved? Let me put it to you like this. Taking risks brings rewards. When no risks are taken then no rewards are to be had. You have to decide on the data at your disposal…are you prepared to take the risk to reach your goal or not and is it an acceptable risk? For me it is an easy answer with acceptable risks because I am NOT stopping my training. Although there are many products I believe ARE too dangerous, the one’s in this discussion are life changing for the over 40 guy and will allow him to reach his training goals and keeping his body, joints and tendons in optimal health. So for me…it is a go! If you have any concerns…best to always talk to your doctor.

Gert Loue HEROES

Ok, now that that is behind us let’s move on to the wonder approach.

Attack Tier ONE

Ever heard of dry needling? It is a fairly new development that has only truly gained ground in the last 5 years or so. Sure it can be very painful, but it produce incredible fast results that can transform you tendons, tennis or golfers elbow problems plus allow you to lift drastically heavier due to muscles functioning better.

Let me explain…As we keep training harder and more intense, the muscles naturally start getting spasms and knots. These knots when left untreated over periods can develop in a “stringy” type knot which is so tight, that the fibres literally push out the blood of the muscle. This means you cannot use that part of the muscle for contraction anymore. The more and more you get these type of knots (and believe me we all get it as time progress) the effected muscle become more and more painful and less operational. Because the muscle is not functioning correctly it will now exert too much tension on the tendon or joint and as a result you will start to develop tendonitis or joint problems and tennis/golfers elbow. Left untreated these stringy knots will completely derail your training and eventually render the muscle out of action. Old school solution was applying extreme pressure on such muscles via specific massage methods, but these proved to be rather unsuccessful. Luckily science have evolved and a MUCH more effective solution has surfaced. It is called dry needling. A process of literally sticking in needles of 3-5cm length into the muscle affected multiple times to stimulate bloodflow again by irritating or “damaging” the muscle slightly. It is all about the bloodflow, when that is restored the muscle relax and heal itself naturally and quickly. This means that a partially operational muscle can be restored to full operation rather quickly. And a fully operational muscle means NO PAIN and no pressure on tendons and joints. Magic hey! …and the best is it WORKS. I’ve been for multiple sessions and can personally vouch for this. Dry needling is done by a Physiotherapist, but I recommend get one who works regulary with athletes.

For the active athlete a visit to the Physiotherapist should be minimum every 3 months even if you feel healthy.

However this goes hand in hand with specific stretches which must be performed on problematic target muscles EVERY DAY! Ask your Physio about these stretches.

Attack Tier TWO

Now that we have covered the physical side of things we move on to other magic things we can do to prevent or limit any muscle, tendon or joint problems.

That “magic” pill is a peptide. More precise it is BPC 157 (Pentadecapeptide (PL 14736))

BPC-157 stands for Body Protection Compound, which reflects its healing process benefits that are getting so much attention. The “157” is a nod to the fact that the compound is a peptide chain built of 15 amino acids.

Read this scientific review paper on BPC-157

While amino acids are natural, the particular sequence of BPC 157 is not, which is why you’ll often hear it referred to as a synthetic supplement. Don’t let this scare you off though as the benefits of this compound are potentially incredible. Why “potentially”? Well test results on rats were incredibly impressive to say the least, but to date no human studies have been completed. So we are still waiting for the final verdict. But simply on the basis of the overwhelming positive rats testing results this is a compound worth considering, at least until we are told differently. Feedback from users (me included) is that this compound hold GREAT promise.

Although it is available as an oral it is highly recommended that one go the injection route (similar to insulin type injections) which result in far greater absorption.

Among many other things BPC 157 will repair torn muscle, tendons and joints and also act as anti-inflammatory.

But although BPC 157 is the nuclear bomb, the basis still needs to be covered. This means you must take

  • Omega 3 and 6,
  • Glucosamine Sulphate
  • MSM

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Now obviously you want to know more about this BPC 157, so here goes:

BPC 157 was first discovered in the gastric juices inside the human stomach that promote the breakdown of food, liquids, and supplements. In particular, one protein was isolated from these stomach acids in its unique 15-amino acid chain. Available as both an oral and an injection-based supplement (similar to insulin injections), BPC 157 via injection is far more popular and effective.

No prescription is required and it is completely legal. Not a single side effect was reported in any of the studies. It is easy available online from various suppliers. You will not find it through your doctor or local pharmacy. If you from South Africa just email me and I can give you the local supplier online details (gertlouwljc@hotmail.com)

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Recommended BCP 157 dosages:

  • 100-pound person: 75 micrograms (μg)
  • 150 lb. person: 110 μg
  • 200 lb. person: 145 μg
  • 250 lb. person: 180 μg
  • 300 lb. person: 215 μg

There are reports of users supplementing with up to 700 μg per day, split between two or three doses.

WHAT ARE THE BENEFITS OF PBC 157

1. Repairs The Brain 

  • BPC-157 can help induce healing of the brain and nerves after atraumatic brain injury.
  • BPC-157 repairs the brain after a hemorrhagic stroke and can reduce swelling.
  • BPC-157 can protect the brain against hypoglycemic seizures (induced by insulin overdose).

2. Protects Against Drug-Induced Damage

  • BPC-157 can protect the gut, the brain, and liver against damage induced from from NSAIDs.
  • BPC-157 can prevent aspirin-prolonged bleeding and thrombocytopenia as well as may prevent and rescue adjuvant arthritis.
  • It can protect the gut from ulceration from chemotherapy drugs.
  • Cuprizone-induced demyelination is an accepted way to study multiple sclerosis in animal models.
  • BPC-157 can counteract the demylenation of cuprizone.

3. Restores The Serotogenic Transport System

BPC-157 works on the serotogenic system.

BPC-157 significantly reduces the rate of serotonin synthesis in the:

  • Dorsal thalamus
  • Hippocampus
  • Hypothalamus
  • Lateral geniculate body

BPC-157 increases serotonin synthesis in the nigrostriatal regions:

  • Accumbens nucleus
  • Lateral caudate
  • Substantia nigra
  • Superior olive

BPC-157 may improve depression and anxiety by its action on serotonin, similar to that of antidepressant drugs (such as imipramine or nialamide).

For example, in chronically stress rats BPC-157 could improve their mobility.

It can also protect the brain against serotonin toxicity as seen in serotonin syndrome via inhibition of 5-HT2A receptor binding.

4. Protects Dopaminergic System

  • BPC-157 also works on the dopaminergic system (increasing release of dopamine in nigrostriatal regions).
  • It can protect dopamine  neurons from toxin-induced damage in models of Parkinson’s Disease (PD).
  • It may also protect against dopamine depletion (from stimulant use).
  • For example, BPC157 can reduce repetitive OCD symptoms from amphetamine usage.
  • It can also prevent haloperidol-induced supersensitivity from amphetamine usage.

5. Enhances The GABAergic System

  • BPC-157 acts in favor of natural homeostasis of the GABA receptors as well as enhancing the GABAergic transmission.
  • It can help with anxiety by enhancing GABA neurotransmission.
  • It can also help with withdrawals and tolerance from GABA-based drugs, such as diazepam, making them more effective.
  • It also antagonizes alcohols effects, including acute and chronic intoxication.

6. Reverses Opioid Tolerance

  • BPC-157 inhibits action on the opioid system.
  • For example, it can counteract the effects of naloxone and thiopental-induced anaesthesia.
  • BPC 157 may also act as an effective paracetamol antidote even against advanced damaging processes induced by extreme overdoses.

7. Protects The Heart

  • BPC-157 can protect the vascular system.
  • It protects cells against toxin induced damage.
  • It can protect blood vessels from oxidative stress.
  • It normalizes both high and low blood pressure.
  • It also promotes formation of new blood via angiogenesis and vasculogenesis.
  • BPC 157 is can also counteract a prolonged QT interval (time between Q and T) from antipsychotic use.
  • It can prevent death from high potassium levels (hyperkalemia), and magnesium overdose (hypermagnesemia).
  • BPC 157 successfully prevents and counteracts bupivacaine cardiotoxicity.
  • It can also help with arrhythmias from electrolyte imbalances.

8. Accelerates Body Repair

BPC-157 can accelerate healing of wounds.

It improves the rate of healing of:

  • Burns
  • Eye (corneal injuries)
  • Fistulas (colon, vagina)
  • Intestinal anastomosis
  • Ligaments
  • Liver (from chronic alcohol intake or tylenol/acetaminophen)
  • MuscleR
  • Nerve Damage
  • Scar Tissue
  • Spinal Cord Injury
  • Tendons
  • Ulcers (Diabetic Ulcers, esophageal)

One way it does this is by its ability to increase activity of the growth hormone receptor.

It can also increase collagen synthesis.

BPC-157 has also shown to improve walking post-injury.

9. Helps With Allergies And Viruses

BPC-157 may help allergies by preventing anaphylactoid (unrelated to IgE responses) reactions.

BPC-157 has viral activity on:

  • Cytomegalovirus (CMV)
  • Dengue types 1-4
  • Feline leukemia virus
  • Hepatitis A
  • Herpes
  • Influenza A and ARBO
  • LCM virus
  • Tick borne encephalitis
  • West Nile fever

10. May Help Irritable Bowel Disease

  • Similar to cholestryamine, BPC-157 may help with esophageal reflux.
  • One way it does this is by rescuing sphincter dysfunction.
  • In rats, higher doses can help with swelling in the gut.
  • By repairing ulcers, BPC-157 can help with ulcerative colitis.

11. Helps With Ocular Dysfunction

By modulating nitric oxide and cholinergic mechanisms, BPC 157 can counteract atropine-induced mydriasis and L-arginine-induced miosis of the pupil.

12. May Help Oral Cavity

BPC-157’s anti-inflammatory effects may be a useful alternative for periodontitis.

13. May Help With Urinary Incontinence 

BPC-157 may help reduce stress-induced urinary incontinence.

Click here for proof of some of the scientific studies done with BPC 157. 

Darn! Now, is this all possible? It just sounds waaaay to good to be true? Only time will tell, but above is facts that came from rats studies. Pure science. Whether all or just some of above hold true for humans, no one knows at this stage, but I for one, is a believer simply by the results I am already getting after just a short period of using BPC 157.

But as I’ve put it many times…there are NO magic pill out there. Sure this might help greatly and might be close to a magic pill, we as older individuals need to apply wisdom to our training methods to always lesson joint and tendon problems.

With all this info now at your disposal, age becomes just another number. You can feel young, energetic and muscles, joints and tendons are now being able to fullfill their intended function without holding you back with pain and injury. Wow man, what a bonus!

Those that wanna join my coaching system for the over 40 guy – you can signup via this link: www.gertlouw.com/my-transformation-secrets/

So everyone…MAKE IT HAPPEN!

Gert Louw

http://www.gertlouw.com

tendon article gert


Over 40 training and joint pain – what to do?

Click here to watch video “Over 40 Ultimate guide for dealing with join pains”

This is very familiar territory for every over 40 guy. We nearly all struggle with joint and tendon pains.

Some of us accept defeat and enter potbelly territory. Well if are you like me, then we refuse to accept even the word “defeat”. It is not in our vocabulary.

But we cannot ignore the aches and pains. So how do we deal with it?

First, the fact is, it IS good, very good, for the over 40 body to be involved in resistance training. That has been proven beyond any doubt by many science studies.

We must just find a way of dealing with the “problem” and not too simply, give up! Dealing with it involves wisdom and quite a few things that we need to do to effectively relief the pain.

Before we start discussing what must be done, remember – NEVER train through pain. You will make whatever the problem is MUCH worse. As you get older you will have to regularly change your exercises and even your whole workout approach and regimen to periodically side-step pains and aches in tendons, joints and back. This is a given. BUT…never, ever, stop training because of pain…adapt and change. Always keep training with what you can do, even if it means a total different temporary training approach.

Joint pain (and tendon pain) is not just simply a result of training heavy. MANY factors play a role.

Let’s go through the list of the things you need to do to relief/avoid tendon/joint pain:

GertLouw30Small

TRAINING

  1. You must have a cutting (lighter weights, higher reps per set) and building (lower reps with higher weights) phase in place to allow regular “rest” periods for the tendons/joints. Phase lengths should be roughly 3 months each.
  2. Consider training lighter for a 6-month to a year period if you struggle with a serious tendon/joint issue.
  3. Very important – never bend your hand upward or downward when lifting, but keep it all times in a straight line with the for-arm. Bending the hand during heavy lifting places undue strain on the elbow via strained tendons. Keeping the hand straight keep all tendons at equal strain.
  4. Bench pressing should be performed with the overhand position with bar resting on the thumb area (bottom) of the palm so that there is no pressure on the wrist. (The place where the bar lies on the hand must be in a straight line with the whole arm to ensure that no strain is on wrist.)
  5. Use special straps to relief strain on the wrist. I will show example in the video. A simple strap fastened around the wrist with a rubber palm grip which can be wrapped around heavy weights. This allows for near zero strain on the wrist joint. This is especially helpful with pull ups, shrugs and nearly all back and upper body exercises.

 

LIFESTYLE

  1. Yip you guessed it…NO SMOKING! Smoking makes the whole body functioning less optimally. It affects nearly everything in the body from the brain to the skin to the lungs to pains and aches that get much worse because of the smoking.
  2. The same goes for drinking. Light drinking (4 glasses wine per week) is max. But even for some this proves to be too much and result in joint pain. In quite a few cases people had to completely stop drinking alcohol in an attempt to get rid of the joint pains.
  3. Too little sleeping. Your body needs time to heal and repair. Too little sleeping rob it of this time. A good (6-8hrs) night rest will go a long way to help the body function optimally.

 

EATING

Our eating habits have a much bigger role to play in joint pain than you might think.

  1. Ensure that you drink enough filtered water per day (3L-6L). This helps washing out the toxins from the body. More toxins = more joint pain.
  2. Enough good oils. Apart from the fact that good oils (omega 3 & 6: peanut butter, olive oil, avocado, coconut) are critical for a healthy functioning hormonal system, it is also very important to help ease joint pain. Cutting out all good oils/fat from your diet will aggravate joint pain and result in low testosterone levels.
  3. You must ensure the body is in an alkaline environment with a PH of roughly 7. The more acidic the body gets, the more joint pain will be experienced, full stop. There are enough serious science studies to back this up. There are also many other advantages when you keep the body in an alkaline state. It has been proven to lessen your risk for cancer and supports a stronger immune system amongst others. On the next page there is a list of ALKALINE and ACIDIC foods to help you adjusting your diet. (A good starting point – lemon juice every morning and evening and cutting out wine and fizzy drinks. MANY people have gotten rid of their joints pains by simply changing their diet to a more alkaline one.)

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Alkaline-2.png

SUPPLEMENTS (natural)

  1. CQ10 (Co-Enzyme Q10). This has been proven by various science studies to be a potent long term pain combatant. However, as with most natural approaches, this only starts working after more than 1 month of continuous usage. [I take 300mg in morning and 300mg at night.]
  2. Even more potent than CQ10, MSM (METHYLSULPHONYLMETHANE) has helped many people changing their lives. It is not a wonder pill but with long term use can significantly ease joint pain. Effective results only achieved after about 3-4 months of continuous use. [I take 400mg morning and 400mg evening]
  3. The 3rd one, eish…this took me some time to support it’s use – CANNABIS oil. I am old school and anything drug-related, even for medical reasons is pretty much “no-go” territory for me. This one took some serious mind changing for me. Eventually I just could not ignore study after study that supported various benefits of CANNABIS OIL. The oil, which contains a higher ratio CBD to THD, is rather harmless when compared to the psychotropic effects of smoking cannabis. It is the THD that result in all this bad effects and the oil has a CBD/THD blend of about 85/15 in most cases which make it mostly harmless. Even here in South Africa the studies are nearly concluded and it looks like we are mere months away from Cannabis Oil being available over the counter for medical purposes. Apart from lowering blood pressure, combating nausea, helping with sleep and fighting cancer, it is actually a potent pain relief substance. 250-raw-cbdAfter about 3 weeks use the body reach a saturation point and then the real pain relieving properties kicks in. If you can get past the mind barrier of taking something that is closely drug related then this could have a drastic positive pain relief impact. And believe me it is not so easy getting past this “mind barrier” for us older folks…but it can be done…I took the plunge. The end result for me – less pain and drastic better sleeping at night. Also drastically lower blood pressure. [I take 1 drop morning, 1 drop afternoon and 5 drops before bed]. Cannabis oil (CBD/THD) has some very interesting medical applications. Some of the claims the cannabis groupies make is not backed up at all by science but some actually are, especially with the latest studies. I think this warrant a future article to give some more insight into this new emerging product (emerging…well at least in the medical mainstream community that is!).

 

MEDICATION

This is a territory you want to avoid. Yes, you can take anti-inflammatory meds, but this is hard on kidneys/liver/stomach and definitely NOT a long term solution.

The last resort and sometimes a necessary route is arthritis medication. There are various types depending on the severity and type of arthritis. A well know anabolic steroid, Deca-Durabolin, is known for its anti-arthritis / joint pain properties. But only your health care provider can do the necessary blood test to determine the problem and plan of action.

However most of the time if you take the points above about training, lifestyle, diet and supplementation seriously enough then you can have pain free over 40+ workouts.

Interested in my customized transformation system for the over 40 guy? Have a look here:  https://gertlouw.com/my-transformation-secrets/

Happy training everybody!

Cheers

Gert Louw

GertLouw39Small.png


Please click here to watch video “CUTTING EDGE SUPPLEMENTS AGAINST PAIN AND CANCER”

When one reaches over 40 and especially over 50 then there are two major concerns that becomes reality for many, constant daily pain and for some the dreaded cancer!

All is not lost. Well for some it is…when one continue on an unhealthy living path (smoking, drinking, and no exercise) well, then the future unfortunately looks a bit bleak.

But just the other day I met a 92 y/o guy, fit, very mobile, with it! So certain things can be done to limit your risks and enhance your quality life.

However even if you do that, constant pain in joints/muscles seems to be part of any person over 40’s life. And so does the possibility of getting cancer.

We use to think it is just by the “throw of a dice” luck that we do not get cancer. But alas, there might just be a way out! Yes you hear right there just might be a very (!) powerful tool in your arsenal that limits your risk for cancer DRASTICALLY.

The same goes for the constant pain. There are 2 weapons in your arsenal to fight this rather effectively.

But first, let’s lay the basic groundwork.

Alpha Lipoic Acid & Potent Multi Vitamin

Two health supplements that form the basis of good health is a good/potent multi vitamin and ALPHA LIPOIC ACID. The best two choices for a potent multi vitamin is OPTIMEN or ANIMAL PAK.

Take the multi vit as directed on the container (must be after meal).

Why the multi vit – well simple you need to ensure that all the basis are covered concerning vitamins and minerals. Just short of one of these can have real bad consequences. This is very important for the older individual. You CANNOT rely on your food to get everything in.

Alpha Lipoic Acid must be taken at 200mg after morning meal and after evening meal.

Why Alpha Lipoic Acid?

Based on evidence from animal and human studies, lipoic acid offers the following essential health benefits:

  • Reduces oxidative stress in the body via powerful antioxidant activity
  • Improves several components of the metabolic syndrome—a combination of risk factors that increases one’s risk for diabetes
  • Reduces blood pressure
  • Reduces insulin resistance
  • Improves the lipid profile
  • Reduces weight
  • Increases insulin sensitivity
  • Improves diabetic neuropathy
  • Protects against cataract formation
  • Improves visual function in glaucoma
  • Helps prevents retinal cell death when combined with vitamin E in retinitis pigmentosa
  • Reduces brain damage after a stroke
  • Prevents bone loss, possibly through an anti-inflammatory effect
  • Removes toxic metals from the body
  • Reduces frequency and intensity of migraines
  • Improves skin texture

Now on to powerful pain relievers (although Alpha Lipoic Acid also play a role to relief pain).

MSM (Methylsulfonylmethane)

The first one is MSM. Now you might have heard about it. But the truth is, IT DOES WORK. But, not immediately. It is not like popping a pain-pill. It is more like reprogramming your body first before it takes effect.

Some of the most common uses for MSM include treating:

  • chronic joint pain (osteoarthritis, joint inflammation, rheumatoid arthritis)
  • leaky gut syndrome and autoimmune disorders
  • osteoporosis and susceptibility to bone fractures
  • bursitis, tendonitis, the development of scar tissue and other musculoskeletal pains
  • allergies and asthma
  • yeast infections
  • muscle cramps
  • constipation, ulcers, upset stomach, indigestion
  • PMS symptoms (cramps, headaches, water retention, indigestion)
  • stretch marks
  • hair loss
  • skin problems including wrinkles, sun burns (it offers some protection against UV light/wind burn), wounds, cuts, skin abrasions
  • eye inflammation
  • poor circulation
  • high blood pressure
  • fatigue
  • oral infections, toothaches, gum disease/periodontal disease

Three uses that MSM has gained the most notoriety for include: acting like an anti-atherosclerotic (preventing the hardening/thickening of arteries), chemo-preventative compound and natural anti-inflammatory. MSM seems to help the body’s natural free radical-scavenging, which means it lowers oxidative stress as the many ailments that come along with it. It’s an effective anti-inflammatory because it blocks the release of pro-inflammatory mediators and down regulates certain harmful signals sent from the immune system that can affect the entire body.

According to the Arthritis Foundation, based on the most reputable studies conducted so far on MSM — such as a 2006 pilot study that analysed the effects of 6,000 milligrams of MSM taken daily by patients with osteoarthritis — it effectively helps improve symptoms of pain and physical function without any major side effects.

That being said, MSM is capable of causing mild side effects for some people, including indigestion, upset stomach or diarrhoea. It’s also not suitable for people taking blood-thinner medications. If you’re pregnant, you’ll want to speak with a doctor before taking it regularly.

Lastly, MSM does NOT start working immediately. It takes up to 3 months for it to start working effectively. For some up to 6 months. So although there is a considerable lead time…it really is worth investing in the long term in using MSM because it IS a powerful pain suppressant with many other health benefits.

Co Enzyme Q10

Now an even more interesting product, Co Enzyme Q10. [Suggested: 150mg after morning and evening meal]

I have written about this wonder supplement in the past and I consider it the “mother of all supplements”. None comes close to it in effectiveness and health boosting ability. And to top it off, it is a significant pain suppressant. To such an extent that many doctors are now at long last starting to subscribe CQ10 to their migraine patients.

Coenzyme Q10 is a mitochondrial energizer that has shown remarkable effects against common heart ailments and neurological disorders. In just the past year, scientists have uncovered specific mechanisms indicating that CoQ10 may have a role in fighting certain cancers. Most surprising, however, are new studies that show how CoQ10 guards against a wide array of common age-related disorders. In this article, we summarize recent discoveries that significantly broaden the clinical utility of CoQ10.

Guarding the Brain After Cardiac Arrest

People who survive cardiac arrest often suffer irreversible brain damage as a result of the disruption of oxygen to the brain. European researchers recently investigated whether combining CoQ10 with mild hypothermia—a technique proven to reduce neuronal damage and increase survival—might enhance the effects of that treatment.

Forty-nine patients who had suffered cardiac arrest and then received cardiopulmonary resuscitation were randomly selected to receive hypothermia (reduction of body temperature) treatment plus CoQ10 or hypothermia plus placebo. The hypothermia treatment involved the patients being placed on a body-surface-cooling mattress.

The patients were then administered either liquid CoQ10 (250 mg followed by 150 mg three times daily for five days) or a placebo through a nasogastric tube. The remarkable findings showed that three-month survival in the CoQ10 group was 68%, compared to only 29% in the placebo group. Coenzyme Q10 thus helped reduce the death rate from cardiac arrest by an astounding 57%. The researchers also found that 36% of patients in the CoQ10 group had a good neurological outcome at three months, versus only 20% in the placebo group.

Preventing the Onset of Migraine

Migraine headaches are a debilitating, all-too-common affliction. Because mitochondrial dysfunction may play a role in migraines by limiting oxygen metabolism, researchers recently explored the use of CoQ10 in preventing these headaches. Published in the February 2005 issue of Neurology, the research describes a placebo-controlled trial of 42 patients in Switzerland.

Patients who had suffered migraines for a year or more, with two to eight attacks per month, were randomly assigned to receive either 100 mg of CoQ10 or placebo, three times daily. At the end of the three-month trial, the CoQ10-treated group had lower attack frequency and fewer headache days and days with nausea than did the placebo group. The mean number of monthly migraine attacks dropped from 4.4 to 3.2 in the CoQ10 group, compared to a negligible decrease from 4.4 to 4.3 in the placebo group.

In this study, supplemental CoQ10 reduced migraine frequency by 27%.

Slowing Early Macular Degeneration

Age-related macular degeneration is the most common cause of vision loss in people over 60. With the deterioration of the macula (a tiny cluster of highly specialized cells in the retina) central vision progressively begins to blur. As the disease worsens, central vision loss may increase until it becomes impossible to perform tasks that require detailed vision, such as driving and reading.

In recent years, researchers have focused on how oxidative damage affects age-related macular degeneration. The eye, one of the body’s most metabolically active organs, not only generates an enormous amount of free radicals through normal function, but also incurs additional oxidative damage from ultraviolet radiation and air pollution. In recent trials, the use of antioxidants has been shown to counter age-related macular degeneration. For example, in an 11-center, double-blind clinical trial conducted by the National Eye Institute (a division of the National Institutes of Health), a combination of antioxidants plus zinc slowed macular degeneration progression in people with intermediate or advanced disease by about 25%.

Hungarian scientists are now exploring a metabolic rather than an antioxidant approach to managing macular degeneration. Citing findings that mitochondrial dysfunction might also play a role in the development of the disease, the researchers designed a clinical trial to evaluate intervention in early age-related macular degeneration with a combination of compounds—including CoQ10—that have demonstrated the ability to improve mitochondrial metabolism. The researchers reported results of their double-blind, placebo-controlled trial last year in the journal Opthalmologica. More than 100 patients with early age-related macular degeneration were randomly assigned to receive either two capsules per day containing 200 mg of acetyl-L-carnitine, 780 mg of omega-3 fatty acids, and 20 mg of CoQ10, or capsules containing an equal quantity of soy oil.

At the end of the 12-month treatment period, the researchers found statistically significant improvement in the treatment group as measured by all four parameters of visual function studied. In addition, only one of the 48 patients (2%) in the treatment group showed clinically significant worsening in visual field mean defect (blind spots in the visual field), the primary study endpoint, compared to 9 of 53 patients (17%) in the placebo group. The decrease in drusen—tiny yellow retinal deposits associated with macular degeneration—of the treated eyes was also statistically significant compared to placebo when either the most-affected eyes or the less-affected eyes were considered. In the less-affected eyes, the drusen-covered area decreased by 23% in the treated group, but increased by 13% in the placebo group. These findings suggest that intervention with an appropriate combination of nutrients that affect mitochondrial lipid metabolism may stabilize and even improve visual functions in early age-related macular degeneration.

New Applications in Fighting Cancer

Research on CoQ10 and cancer has focused on two lines of inquiry: CoQ10’s ability to improve immune response and its ability to decrease the cardiotoxicity caused by a common class of anti-cancer chemotherapeutic agents.

Patients with cancer often exhibit low levels of CoQ10,6,7 and researchers have shown that CoQ10 can increase immune response in humans.

Based on these findings, Danish researchers investigated CoQ10’s effects alone and in combination with other nutrients as an adjunctive therapy for breast cancer.

In one case report, the researchers describe three breast cancer patients with metastasized cancer. The women underwent conventional cancer treatment and supplemented with a daily dose of 390 mg of CoQ10. All three women demonstrated tumor regression and decreased incidence of metastasis.

In another study, the same research team investigated 32 high-risk breast cancer patients whose malignancy had spread to the lymph nodes. In addition to conventional therapeutic interventions, this group of patients received a daily combination of nutrients (vitamin C: 2850 mg; vitamin E: 2500 IU; beta-carotene: 32.5 IU; selenium: 387 mcg; and secondary vitamins and minerals), essential fatty acids (1.2 grams of gamma linolenic acid and 3.5 grams of omega-3 fatty acids), and 90 mg of CoQ10. At the end of the 18-month trial, six patients showed apparent partial remission, none of the patients showed signs of additional metastases, and their quality of life improved. None of the patients died during the study period, though four deaths were expected based on the patients’ disease stage. In one of the six patients with partial remission, the dose of CoQ10 in the nutritional protocol was increased to 390 mg. After two months, that patient’s tumor had disappeared completely, as confirmed by a mammogram.

While chemotherapy drugs can be highly effective, their use can also be limited by toxic side effects. This has been noted in the case of anthracyclines, a class of drugs widely used in cancer chemotherapy. These drugs have demonstrated efficacy in the treatment of leukemia, lymphomas, and solid malignancies, and are often used to treat breast cancer, with higher doses yielding greater clinical responses. These higher doses of anthracyclines, however, can produce toxic effects on heart tissue, possibly leading to cardiomyopathy and heart failure that are not responsive to conventional pharmacological interventions. In fact, anthracyclines selectively damage mitochondria in the heart, but not in other organs. Since coenzyme Q10 supports both heart tissue and mitochondria, researchers conducted human trials to determine whether CoQ10 might prevent cardiotoxicity during the administration of anthracyclines.

Two recent review articles addressed CoQ10’s potential as an adjunctive therapy during chemotherapy with anthracyclines. Writing in the Journal of Clinical Oncology, researchers summarized five reviewed studies in which CoQ10 was given along with anthracyclines. They report that in three of the studies that measured heart rhythm, patients who received CoQ10 showed favorable changes suggesting that CoQ10 might have a stabilizing effect on the heart. They also note that supplementation did not interfere with anthracycline treatment, and that no adverse effects were reported in any of the trials. The authors concluded that although coenzyme Q10 demonstrates potential for reducing cardiotoxicity, larger and more rigorous investigations are needed.

Slowing Neurodegenerative Disease Progression

Many investigators have conducted preclinical studies examining how oxidative stress and impaired mitochondrial function may contribute to neuronal cell death, a characteristic of Parkinson’s, Alzheimer’s, and other neurodegenerative diseases. For example, a recent journal article in Toxicology and Applied Pharmacology reported on the effects of the herbicide paraquat on neuronal cell death in the laboratory. The researchers found that this toxic chemical damaged mitochondria and increased free radical production, eventually resulting in the death of neuronal cells. Pretreatment of the cell cultures with CoQ10, however, inhibited both mitochondrial dysfunction and free radical generation. The researchers postulated that coenzyme Q10 may prove useful in preventing and treating neurodegenerative conditions related to environmental toxins.

While published research on the use of CoQ10 in slowing the progression of Alzheimer’s disease has been limited to preclinical studies, investigations of CoQ10 and Parkinson’s disease have moved into clinical trials, including randomized controlled studies. This work has been led by Clifford Shults, MD, professor of neurosciences at the University of California at San Diego School of Medicine. In Parkinson’s disease, brain cells that produce the neurotransmitter dopamine progressively die. Research in animals has shown that CoQ10 can protect the substantia nigra, the area of the brain where these cells reside. Studies by Dr. Shults and others have shown that mitochondrial dysfunction and diminished mitochondrial CoQ10 levels frequently occur in Parkinson’s sufferers.

With funding from the National Institute of Neurological Disorders (a division of the National Institutes of Health), Dr. Shults and his colleagues undertook the first double-blind, placebo-controlled, multicenter clinical trial of CoQ10 in patients with early untreated Parkinson’s disease. In this phase II, dose-finding study, 80 patients were randomly assigned to receive one of three different CoQ10 doses (300 mg/day, 600 mg/day, or 1200 mg/day) with vitamin E, or a placebo containing vitamin E alone. The patients were followed for 16 months or until the participants required levodopa, a standard drug treatment for managing disease symptoms.

The results, reported in the Archives of Neurology, showed that patients who received the largest dose of CoQ10 (1200 mg/day) had 44% less decline in mental function, movement, and ability to carry out activities of daily living than those who received the placebo.19 Patients who received CoQ10 doses of 300 mg/day and 600 mg/day also showed some slowing in decline compared to the placebo group, but not as much as those who took the highest dose. The authors concluded that CoQ10 was safe and well tolerated at doses up to 1200 mg/day.

A clinical trial has also been undertaken in patients with Huntington’s disease, a neurodegenerative genetic disorder. This trial, conducted by the Huntington Study Group, randomly assigned 347 patients with Huntington’s disease to receive CoQ10 at 600 mg/day, remacemide hydrochloride at 600 mg/day, a combination of both, or placebo. Over the 30-month trial, the CoQ10 treated patients showed a 13% decrease in overall functional decline and beneficial trends in some secondary measures. However, the difference between the CoQ10 group and the other groups did not reach statistical significance.

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METFORMIN

Now on to the last miracle supplement. Metformin [suggested 500mg daily]

This is actually not a supplement but a prescribed medicine for diabetics. However it seems to do much more than just treating diabetics and all of it is good, very good news!

Let me give you the rundown…

[From the US National cancer institute]

“In 1957, the first results from a clinical trial of the diabetes drug metformin in patients were published. Yet, it would take nearly 40 years for the drug to be approved in the United States as a treatment for type 2 diabetes.

Now researchers want to know whether this decades-old drug may have additional uses in another disease—cancer. Based on findings from a number of large epidemiologic studies and extensive laboratory research, metformin is being tested in clinical trials not only as a treatment for cancer, but as a way to prevent it in people at increased risk, including cancer survivors who have a higher risk of a second primary cancer.

Numerous early-stage clinical trials are currently under way to investigate metformin’s potential to prevent an array of cancers, including colorectalprostateendometrial, and breast cancer. Several of these trials are being funded by NCI’s Consortia for Early Phase Prevention Trials. And NCI is collaborating with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to study participants from the landmark clinical trial, the Diabetes Prevention Program (DPP), to investigate metformin’s impact on cancer incidence.

Some of the early-phase prevention trials of metformin are enrolling participants who are at increased risk for cancer and who are obese, have elevated glucose or insulin levels, or have other conditions that put them at risk for diabetes.

“With the obesity epidemic, these studies are applicable to a substantial portion of the U.S. population and, increasingly, of the world population,” said Brandy Heckman-Stoddard, PhD, MPH, of NCI’s Division of Cancer Prevention.

Expanding the Data Pool

Much of the human data on metformin and cancer has come from epidemiologic studies of people with diabetes. In many, though not all, of these studies, people with diabetes who were assigned to take metformin had a lower incidence of cancer than those taking other diabetes drugs.

Completed in 2002, the original DPP enrolled more than 3,200 people at increased risk of developing diabetes and randomly assigned them to one of three groups: one group received metformin, one took part in an intensive diet and physical activity program, and one received a placebo. Participants in the metformin arm had a substantially lower risk of developing diabetes than the general population; participants in the exercise and diet regimen fared even better.

With NCI’s involvement, the program’s extension, called the DPP Outcomes Study, will allow investigators to document cancer incidence and death among study participants. Those observations should provide some of the strongest data available to date on metformin’s anticancer effects in people without diabetes, explained Dr. Heckman-Stoddard. The first data on cancer outcomes in study participants, which will be based on 15 years of follow-up, should be available in 2014.

“Once we have that data, there are a host of other questions we can ask,” she said. For example, Dr. Heckman-Stoddard and her colleagues plan to study metformin’s impact on certain blood biomarkers that studies have suggested are associated with cancer risk. They will also study the drug’s mechanism of action—that is, how metformin may work to prevent changes in cells that can lead to cancer.

For Prevention, Small Biomarker-Driven Trials

The smaller prevention trials being conducted are very different from the DPP Outcomes Study. These trials are not designed to determine whether metformin prevents cancer. Prevention trials must generally have a large number of participants and span many years to show whether a drug or some other intervention reduces the risk of cancer.

Instead, these short, 3- to 6-month trials are investigating whether the drug has an effect on specific proteins and/or signaling pathways that have been implicated in cancer development and that laboratory studies have shown are affected by metformin.

At the University of California, Irvine Chao Family Comprehensive Cancer Center, for example, Jason Zell, DO, MPH, is leading an early-phase clinical trial that is testing metformin’s effect on the mTOR signaling pathway in obese people who have previously had precancerous growths removed from their colons.

Numerous studies have implicated the mTOR pathway as an integral hub in cancer development and progression, and laboratory studies have consistently shown that metformin can blunt mTOR signaling.

“The key point of the trial is to get at the mechanisms of action … to see if metformin is behaving in the expected manner” based on the lab findings, Dr. Zell explained.

Numerous early-stage clinical trials are currently under way to investigate metformin’s potential to prevent an array of cancers, including colorectal, prostate, endometrial, and breast cancer.

Dr. Zell and his colleagues chose to study obese patients “because of the interesting side-effect profile of metformin, which can include weight loss,” meaning it may not be suitable for underweight, nondiabetic individuals, he continued.

If this first trial shows that metformin is having the expected effects on mTOR signaling, the next trial would be similar but would measure a clinical outcome, such as whether metformin decreases the number of colorectal polyps that return.

phase II trial at the University of California, San Diego Moores Cancer Center is testing metformin’s effects on a host of biomarkers in postmenopausal breast cancer survivors who are obese.

Funded by NCI’s Transdisciplinary Research on Energetics and Cancer (TREC) program, the trial, called Reach for HealthExit Disclaimer, will involve treatment with metformin alone and in combination with an exercise program. The study will examine the effect of 6 months of metformin treatment, with or without exercise, on a host of biomarkers associated with cancer risk. The change in biomarker measurements before and after treatment will be compiled into a score that predicts the risk of dying from breast cancer.

This is all part of the trial’s novel “biomarker bridge” design, the lead investigator, Ruth Patterson, PhD, explained. The biomarkers and the risk score are being derived from an analysis of tissue samples collected as part of an NCI-supported phase III trial called the Women’s Healthy Eating and Living (WHEL) study. This study found that a diet low in fat and high in fruits and vegetables did not reduce the risk of cancer returning in survivors of early-stage breast cancer compared with survivors who maintained their normal diet. Researchers have continued to follow the health of WHEL participants to document their health outcomes, including death from breast cancer.

“The WHEL trial is over, and we have a freezer full of blood samples, and we know participants’ breast cancer recurrences, mortality, and other outcomes,” Dr. Patterson said. “So we’re hooking together a short-term trial with a long-term cohort study by means of blood biomarkers.”

The Dose Is the Question

Most of the cancer clinical trials of metformin use the same doses typically used to treat diabetes. That makes sense, because all of the epidemiologic data suggesting a cancer benefit came from studies that used those doses, said Michael Pollak, MD, of McGill University in Montreal, who has extensively studied metformin and its anticancer potential.

“We already know that those doses are safe, so why not study them?” Dr. Pollak continued. “But then you have to realize that virtually all of the lab studies [of metformin] have been done using drug concentrations that are as much as 100-fold higher than those found in the serum of diabetic patients. So the lab studies do not directly justify the clinical trials that are using conventional antidiabetic doses.”

With the obesity epidemic, these studies are applicable to a substantial portion of the U.S. population and, increasingly, of the world population.

—Dr. Brandy Heckman-Stoddard

Although laboratory studies suggest that larger doses of metformin “deserve study” for cancer treatment, Dr. Pollak noted that “for cancer prevention, we can only consider the hypothesis that the antidiabetic dose, or even lower doses, will be clinically useful.”

Dr. Zell agreed. “In the realm of cancer prevention, where side effects are less acceptable than they are in the realm of cancer treatment, the conventional dose for treating diabetes or something close to it may be the limit.

“I don’t imagine that prevention researchers will be looking to use [significantly larger] doses of metformin,” he continued. “In a healthy population, even a low risk of side effects could be extraordinary when applied to a larger population…. That’s why trials like ours are important. At the end of this 12-week intervention, we’ll have a good idea of whether the standard dose of metformin can affect cancer signaling pathways.”

Early Days

It’s still far too early to tell whether there is any future for metformin as a means of preventing or treating cancer, several researchers said.

Despite the very strong epidemiological evidence, there’s a chance that, even if metformin has some ability to prevent cancer, its efficacy may be limited to just several cancer types, Dr. Pollak noted. For example, metformin is not absorbed very well by the body and is absorbed differently by different tissues, he explained, which could limit how effective it might be against particular cancers.

Although the drug in its current form has certain limitations, some investigators are working on developing more potent derivatives of metformin. At the 2012 San Antonio Breast Cancer Symposium, for example, Italian and U.S. researchers reported that several metformin derivatives they had developed potently blocked the growth of breast cancer cells in the laboratory, including cell lines of triple-negative breast cancer, and caused the cells to die.

To be used for cancer prevention, any metformin derivative would have to be safe, with few side effects, Dr. Heckman-Stoddard stressed. As for the original metformin formulation, she added, current trials should help to map the way forward for its use in prevention.

“It’s important that we identify the right populations in which this is most likely to be an effective agent,” said Dr. Heckman-Stoddard. “We need to look at the evidence from all of these early-phase trials as a whole,” she continued, including examining the population groups exhibiting the strongest suggestions of efficacy “so we can design efficient phase III trials.”

Examples of Clinical Trials Testing Metformin for Cancer Prevention

Trial Phase Measured Endpoints Sponsor
Exercise and Metformin in Colorectal Cancer Survivors II Insulin levels and other biomarkers Dana-Farber Cancer Institute
An Endometrial Cancer Chemoprevention Study of Metformin [and Lifestyle Intervention] III Biomarkers in the endometrium and insulin levels University of Texas MD Anderson Cancer Center
Metformin as a Chemoprevention Agent in Non-Small Cell Lung Cancer II Progression of potentially precancerous bronchial lesions (secondary endpoint) in patients who have undergone surgery for lung cancer Mayo Clinic
Prostate Cancer Active Surveillance Metformin Trial II Progression of prostate cancer in men undergoing active surveillance for low-risk disease University Health Network, Toronto
Metformin Hydrochloride as Chemoprevention in Patients with Barrett Esophagus II Changes in the levels of the signaling pathway protein pS6K1, thought to play important role in progression to esophageal cancer Mayo Clinic”

 

The bottom line is that Metformin has already proven to be a powerful tool against some of the most common cancers.

Here is a article by Medscape on whether everyone should be taking Metformin due to it’s incredible benefits: http://www.medscape.com/viewarticle/835676

 

WANT A HOLISTIC TRANSFORMATION SYSTEM FULLY CUSTOMIZED?  The program I am following for the past 6 years (age 46 to 52), available now fully customised on all levels. before-and-after-dec2016Every little secret, every hard-earned practical fact, every scientific study that actually support the (very) few supplements between all the thousand ridiculous advertisement claims have been filtered en incorporated into one system that MAKES A DIFFERENCE click here: 

https://gertlouw.com/my-transformation-secrets/

 

Metformin has been proven to be very safe even for non-diabetics. But since it is a prescription drug you will have to twist your doctor’s finger to get a prescription. Ask him to look at the anti-cancer and weight-loss properties of Metformin…this might change his mind.

So here you have it – 5 powerfull tools in your arsenal for good health, anti pain and anti cancer. As the Vulcan say “Life long and prosper!”

Happy Training

Gert Louw

Gert Louw video cover


 

Click here to watch video “How to get a winning mindset for a WOW transformation?”

Nearly all of us have this dream to be the best we can be. Too have a great, ripped, muscled physique that impresses and exudes health, wealth and happiness. We seemed to have been programmed with this urge and I believe that to be true…we are created in the image of God.

But back to reality, life is difficult. Work, school, studying, marriage, family, kids, meetings and a rat race trying to stay ahead and on top.

I have a blueprint transformation system developed to create the environment for growth and fat loss…have a look here:  https://gertlouw.com/my-transformation-secrets/

We easily make decisions at the beginning of a new year or after being inspired by someone to reach for that dream body we so much want.

And sure, that is the first and most important step each of us have to take on the road to success BUT, and this is a very big BUT, 99% of those taking this first step have not acquired and mastered the mindset that needs to be in place to push through to reach goal and beyond.

Gert Louw AGULHAS

Let’s look at important aspects of this mindset that must be in place before the journey starts:

 

IT WILL HURT

Do not think for one moment reaching a dream body is without pain. LIFE IS PAIN! You will never ever be in a situation where you will not experience some form of physical or emotional/other pain. Being alive, means that you WILL experience pain. The whole idea is to minimize, control and use this pain to your advantage. To reach your dream physique you will be working out intensely. This will cause muscle pain and resultant muscle growth. Learn to LOVE this pain…this is a signal that you are stimulating your body for growth. There might be injury on your path. This is part of any sport environment. Learn to work around it and do NOT let it derail your efforts. For example: When you have a knee injury, nothing stops you from concentrating on the upper body workouts until it is healed. Even with back injuries under guidance you can still workout safely.

 

IT WILL TAKE TIME

The Hollywood and Western Culture has programmed us to want immediate results and satisfaction. Get that out of your mind very quickly. That is the single biggest reason why people do not push through. We want it and we want it now and if it does not happen within a month or two then why bother. I got one thing to tell you – “NOTHING, BUT NOTHING IN LIFE THAT IS REALLY WORTH IT COMES EASY.” Accept that. A dream body is not designed in months , not even in years for some. It took me 11 years to get to the best shape of my life. Month after month there are small differences and they add up to significant differences on yearly basis and wow differences every few years. You cannot get to the top of a ladder without climbing the steps…only by going up step by step do you get to the top. Sure there are shortcuts people try to take but nothing this side of anabolic steroids can and ever will produce magic results (even with anabolics it takes time and a very focused approach and is NOT an overnight process!). Do NOT believe marketing advertising of supplements. 99% of what is printed and claimed is complete and utter lies.

 

IT WILL REQUIRE DEDICATION

There is no easy way to say this…You will need to be at gym 4-5 days a week, you will need to motivate yourself for intense workouts (and learn to love it!), you will need to make extreme effort with your diet preparing the food the day before, you will need to have 100% dedication to your supplement regime. This is what it will take.

 

YOU WILL CHANGE YOUR LIFESTYLE

Right now you are probably hanging out with your mates every evening. In future you will have to cut social time to the bare minimum. Your time and focus will now be in a new environment. You need to brace yourself for a total lifestyle change – friends, socializing, eating habits, time spend and more.

Having family requirements make it more challenging but not impossible. In fact your life partner and kids will see the changes and your dedication and that will instill in them even greater respect for you. You will lead now by example and what you are showing them is the best possible example a father can show to his children…that if you want something badly in life, you have to put in the effort and dedication to get there, you will show them everything worth something in life comes with great effort and dedication.

Many people also ask me how I bring my faith in Jesus and my fitness lifestyle together. They see a good looking shredded, muscled guy and struggle to bring faith and this lifestyle in the same environment. I find it very easy and actually find that my dedication to the fitness lifestyle brings me closer to God because it teaches me dedication and discipline. For me Jesus Christ is in the center of everything I do. I never cut Him out of anything and I am not shy to give Him the credit for what I’ve reached. Even before I sometimes do a heavy set…I will quickly close my eyes for strength from my Lord. I don’t care what people say or think around me…I am not doing this for them…I am doing this for me.

 

THERE WILL BE TEMPTATION

Be under no misconception…there will be many reasons for giving up. This is the exact reason why so few reach success. You will be hungry, you will miss out on drink dates with friends, you might even have to change friends, your body will ache and pain and there will be days that you feel drained and without focus. Those are the days that you just have to PUSH THROUGH and JUST DO IT. Just get yourself to gym and just do what you need to do. Steer clear from foods that tempt you. Do NOT keep those foods in your house. Temptation is what will separate the men from the boys.

Never use work-pressure or deadlines as an excuse. You HAVE to find your solutions around that. If it means early morning or late evening training, so be it. NEVER use the excuse “but I cannot stick to the meals because I do not have time at work to eat.” It takes you 2 min to pour water in a shaker, put in the protein powder and shake and drink it…2 minutes, nothing more!

This especially is one of the key areas where I found my faith helps me a lot to stay focused.

 

The above is just some of the key areas for the right mindset, but I believe these are the most important.

Master them and you WILL reach success.

Success is within each of us but so is failure as well.

You have been given the ability to reach to the stars and be everything God ever meant you to be…DO NOT LET THIS WONDERFULL GIFT PASS YOU BY.

 

I wish you success on your journey.

Be blessed

Gert Louw

TRANSFORMATION COACHING – more info here:  https://gertlouw.com/contact-me/

Gert Louw COACHING


Walking by faith – Everyone knows by now there are a deeper side to me and a life altering back story.

But I have never really told my story about my walk in faith.

I am opening my heart here and I know there are risks…because the world is not always a good place to lay your heart bare. But this is the time to do it…my walk in faith has brought me to this point where I feel compelled to share.

So those that want to know about a story of pain, hope, miracles and LIFE, read on.

As many of you know, 11 years ago (at age 40) I was lying on my “deathbed” in hospital. At one point no blood pressure and heartbeat and ready to die. A brutal attack and mutilation left me with a broken soul and the will to live has left me, my heart was filled with darkness and pain which I could not carry anymore.

Me 2 months after hospital:

rotaste1

 

Then the unexpected happened. While I was lying in my hospital bed, weak and not expecting anything but death, I heard a voice, God’s voice. The voice was clear…”Gert, I am offering you life…I have a plan for you. You must choose…”

I cannot put in words that moment…I experienced an incredible beauty, softness, kindness, pureness,  holiness, love and I saw LIFE…and in that moment my life changed. I was heartbroken, I was weak and I spend a lot of time in conversation with God over the next few days lying in my bed. I was soooo close to choosing death…but this unexpected experience showed me LIFE and I made my choice.

Sure, before this I knew about God and I knew the Bible. But this changed my world. Suddenly God was not just in a book anymore but He was more real to me than this world around me. And for just that brief moment I felt the touch of God…and I was utterly overwhelmed and unprepared.

Two weeks in hospital and I was strong enough to leave. Prognosis not good…some doctors gave me a couple of years. But it was not in their hands, I chose life and God was in control.

I was a changed man…but, the pain and darkness in my heart of what happened was not over. The weakness I have, is that I put a lid on things and push it deep down, trying to bury it…never really dealing with it.

My walk in faith deepened over the next years.

Now at 51 I am a living miracle of God. The body is still broken. Kidneys functioning at 50%, struggling with my liver, and that is just the tip of the iceberg with my serious health problems. But that is insignificant for God…look at me…with my severe health issues and being expected to be long dead by now, God has turned this around to the extend that I am looking the healthiest and fittest I ever did in my life. For Him, NOTHING is impossible.  He is in control, not the doctors, not me, not medical science.

Me, today…4 months away from 52:

gert

 

Now this all sound incredible and it is, but my world was about to be rocked again. God knew that the pain and darkness that I am trying to bury needs to be addressed. Every now and then an event triggers the lid from coming off slightly and the pain and darkness boils over. And recently the Holy Spirit kicked off that lid for good. All that pain and darkness surfaced and there was no way I could put back the lid on again. The Holy Spirit do not mess around…that lid was gone!

I struggled to breath, it felt like my heart was tearing in two…I pleaded with the Holy Spirit to please ask God to come and take my life…I could not bear the pain, it was overwhelming. My power to push it down was gone.

 

But let me give you a glimpse into how incredible God works.

The Holy Spirit literally forced me to walk into a church I do not know the next day, and walk up to the first friendly face I see and tell him I need someone to pray with me, now (!)  and intercede on my behalf before God. Now anyone that knows me, will realize this is the worst thing anybody can ask me to do. I am a total introvert, sitting always quietly in the corner doing my own thing and NEVER EVER just walk up to people I don’t know, let alone in an environment total foreign to me. This was going against everything I am.

But instead of doing this, I wanted to die, because this darkness and pain was so intense and overwhelming that again I was at this crossroad point in my life where I had to choose between life and death. I had a young son who I adore and a beautiful loving wife and if it was not for them chances was I was going to choose the easy road out. I was breaking down in tears continuously…and I am NOT an emotional person!

So I DID IT! I just did it in total obedience. I went to the church the Holy Spirit indicated to me, my wife and son by my side. I walked up to the first friendly face I saw and I told him what the Holy Spirit instructed me to do. He smiled and said I must go and sit, someone will come to me. A few moments later a guy, my age, walked up to me and touch my shoulder and smile. We went to a quiet corner outside and I told him my story, laying my heart bare, told him of my pain and the way the Holy Spirit is working with me now. We bend down and started praying, he laid me before God…during this moment the Holy Spirit told me that because of my obedience, He will now plea my case before God and lay my pain of the darkest corners of my heart before God. I could hear it, I could literally hear the murmurings, not words, but I could hear everything. I felt the touch of God as I did in my hospital bed and broke down in tears by grace I do not deserve. God once again began the 2nd miracle in my life, healing my pain in my heart.

The following week was extremely emotional for me as the Holy Spirit carried me through this process of cutting the pain in my heart out, piece by piece.

I thought my walk was close with God previously, but had no idea how intense it was about to become.

This God I bow down too, has become more real than anything else in this world. I am totally unprepared for how amazing and incredible His love, His holiness, His power and His kindness is.

 

So many people I talk to over the internet ask me “Why do God, if He is a good God, allow this pain and suffering in this world to continue?”

The world is a broken place. We have made our choices to abandon God and with it comes pain and suffering. God is the ultimate gentleman…He NEVER force His will on anyone. Bad things happen to even good people everyday…and you know what, it strengthens you to become a stronger person reaching greater heights. Look what happened to me…through it God strengthened me to reach heights I thought never possible in my life and I am touching many lives out there and helping people. I am a hard nut to crack and God knows it. He had plans for me…but left to my own devices that plan would never come into play. He allowed things to happened to me and come over my path. Bad things…like Job, but like God is, He turned everything around into blessings beyond believe. I still had to make the choices myself…but God gentlemanly lead me in the direction…

God wants so much the best for us, but when we abandon Him we are left alone in this broken world. The heart of God is such that He allowed that, which was most precious to Him, to be put through pain and mutilation and to die on a cross for us, just so that me and you would have direct access to God and the Holy Spirit.

My sins in this broken world prevents me from having a direct link with God, because before God nothing that has any sin or darkness can stand and live, nothing. God is pure and holy. Only through the sacrifice of Jesus, who was blameless, could He die in my place and through that allow me to talk to God and be saved. It had to be someone blameless, he had to had no sin because that is the only way He could die for ours.

God could have sent armies of angels to rescue Jesus, but this shows God’s heart…unmeasurable kindness and compassion. He did not have to do this for us…He is the Almighty God, rescuing us just by grace…which we do not deserve.

 

Now, many devoted believers don’t like it when they hear of someone like me who had such incredible experiences with God, the Holy Spirit and Jesus Christ (I had Christ holding His hand on my shoulder at one of my toughest moments in prayer and more…)

Why me, what makes me special?

Remember Maria?…remember that between all the disciples of Jesus, SHE was the one that quietly bent down with her tears falling on Jesus feet and rubbed very expensive oil/perfume over His feet, no words, just an act of utter compassion. His disciples were not impressed about the logic that such expensive perfume was wasted. But she had a relationship with God on another level, why?…because of the AMOUNT of grace she required to be saved. Be happy and joyful if you required little grace to follow God, then you are blessed indeed. People like me (and Maria) carried so much pain and darkness in our hearts that the grace we require, is massive. This amount of grace changes you on every level and your relationship with God, is extremely intense.

 

Last week on one of the biggest radio stations in Cape Town, they aired this young woman who had a vision where Jesus Christ appeared to her and told her: “Go and tell the world, I have finished preparing all your places in heaven. I am coming to fetch you. The time is up.”

The Holy Spirit confirmed this in my heart…

Now, I know God said, no one knows the date and time, but I am making sure me and my family is ready…I cannot wait to join my Lord and Saviour!

 

I pray this article means something to you…it comes from deep within my soul.

Be blessed.

Gert Louw

Gert Louw staring


 

Click here to watch video “How to change a transformation into a Super Hero transformation

 

In a lot of my videos you will notice I am talking about not just changing the outside of the body but also the inside.

The outside (muscles, looks), that make but a small part out of what you really are. By far the biggest part is that what you are inside. How your heart is, because no transformation is worthwhile if you do not also transform the heart.

So this article is where we get a little deep. Here I am going to talk about something you can add to your life that will not just make you feel incredibly good about yourself but can have life changing impact to those crossing your path….and can literally make the difference between life and death for some…

Now understand me, I am not putting myself on a pedestal here…believe me (!) I am still working very hard to change from the inside for the better. It is a process that probably be never complete. For one man it was and is and that is Jesus Christ and that is my role model I aspire too.

Ok, let’s get deep for a moment…

If you’ve been spared suffering, real suffering, the kind of suffering where you sit in a corner and cry hopelessly, you are blessed. A suffering where you want to die, but you do not have the guts to do it yourself. A suffering where all hope is lost and the pain and despair goes deeper than your bones. A suffering where it feels as if your heart is tearing in two and you struggle to breath…

MANY, MANY people are at that point, whatever the reason. The reason is not important, the world is a broken place and there are a multitude of reasons. The fact is those people have reached the bottom of a pit where all hope is lost. Their will to live, their humanity stripped from them. I was there myself, and know what it feels like.

The broken people are people you see around you. People you work with, sometimes people very close to you. They hide their pain to protect themselves because through their experience, showing pain and hurt would bring further pain by rejection because people do not want to be bothered by those in despair. Entertainment, laughing and be happy is all we are interested in…

But you know what, those people do not want your Bible verse, they do not even want your money and most of the time they do not want your solutions…because they believe there are none. All that people want and really NEED is a loving gesture of caring. A soft hand touching their shoulder lovingly, a hug with no words that just say “I am here for you”, just sitting quietly by them…just be there. They need hope because they have lost all hope. Caring gives them that hope and caring restores their humanity.

That gesture can be as little as a friendly and loving smile.

But when it comes to do something physical help, then you can CHANGE lives – when you are ready to get out of your comfort zone and physically help your fellow human being who have lost all, including hope, that is when amazing things happen.

Sadly the world is what it is because of us, no one else. But we have it in us to make it so much better. We are created in the image of God, but we fail soooo many times to live this because we don’t want to change our hearts.

If you want to really change from the inside who you are…this is one of the most powerful places to start. To become part of these people’s lives and see what great impact you can have gives an immense positive feeling, which you will never ever reach by even the most amazing body transformation. This is powerful stuff!

Make it your daily mission to show just one different person, every day, you care.

This is true transformation – body and soul! The most beautiful people who have ever crossed my path was the ones who had immense inner beauty with their amazing kind and compassionate heart. That overshadowed any aspect of their outer beauty for me and later on that inner beauty was all I could see. Now imagine you transforming your body and become this incredible “wow” physique, and at the same time the inner beauty becomes so immense that it start to overshadow even this incredible body transformation…now THAT is true beauty…super hero beauty!

 

Those with cancer: https://gertlouw.com/2013/10/28/fighting-cancer-to-survive/

Those with Fibromylgia: https://gertlouw.com/?s=Fibromyalgia

Those with hiv: https://gertlouw.com/2013/02/19/bodybuilding-for-hiv-guys/

 

kindnessD

You, me, together we all CAN make a difference in life’s, simply by caring…

 

Wish you all a great day.

Gert Louw

Arniston red shirt flex Gert Louw

 


Click here to play video “How to eradicate joint pain”

 

Joint pain is probably the most common injury a bodybuilder struggle with. And the bad part is, as you pass the 40 y/o mark the challenges increases drastically to walk the narrow pain-free road with your joints.

In this article I will explain how to train to avoid /minimizing joint pain and then also give some options as a last resort for effective treatment considerations.

 

When we speak about joint pain then we generally refer to any of the following:

ARTHRITIS, BURSITIS (aka Tennis/Golfers Elbow), TENDONITIS

The good news is that all three can be nearly fully avoided, even for us older folks. (I am not taking into account genetic predisposition to arthritis or similar conditions)

 

A very effective avoidance principle

Few of us employ the basic training principles required for avoidance. It is so simple but our aim and eagerness to grow is the main culprit here.

The human body CANNOT take increasing punishment month after month for an extended period.

IT WILL BREAK! And the first to go is your tendons, joints and immune system.

Younger guys can get away with it to a certain degree but as you age your body has less testosterone and growth hormone available and the healing and repair slows down = breaking easier.

The avoidance principle is as follows: A Three month Building Phase must be applied and followed by a three-month Cutting Phase in a very specific way and repeated.

Click here to play video “Cutting & Building phases explained”

 

During the Building phase you will punish your body severely and consume higher calories. This is where growth occurs. You will increase the weight sizes (sets of 8 reps) with a maximum of 10% every 14 days. NOT MORE THAN 10%! Even if you feel you have to power, DON’T! Your tendons and joints need time to strengthen in a structured gradual approach. Bypassing this step-up gradual approach and you WILL run into joint and tendons problems. This I guarantee you.

The Building phase will be continued for a 3 month period.

Click here to play video “Building Phase diet”

 

At the end of the 3 months you will enter the Cutting Phase. This Cutting phase’s purpose is to allow for tendon and joint healing and to cut the body fat down for a shredded look with fewer calories consumed daily compared to the Building phase.  You will cut the weight sizes lifted on ALL exercises by 30% and increase the reps per set to be 15-20 for all exercises (from the 8 reps per set on the Building phase). You do NOT train to failure in the Cutting phase. Your body needs time to repair and strengthen the tendons and joints after the hammering of the Building phase. This is a CRITICAL approach for joint health and the moment you bypass this alternating Building/Cutting phase approach you WILL run into problems.

The Cutting phase is NOT a phase for growing muscles but simply to maintain them while allowing the body time (3-months) to heal and strengthen tendons and joints.

Click here to play video “Cutting phase DIET”

 

Three months is considered the safest and best approach for the length of the phases. If you lengthen the time of the Building phase, the risk for joint/tendon injury will skyrocket.

I again emphasize: Do NOT underestimate the importance this approach is playing for joint health. It is also a method employed by most successful bodybuilders.

 

Just a short note on TENDONITIS

Tendonitis is inflammation/damage of tendons and can sometimes be dealt with an over the counter medication like aspirin or ibuprofen (ask your health care worker).

Tendonitis can be fairly easily avoided/managed by applying the following basic principles:

  • Warm up thoroughly, gradually building the intensity level of your workout. Cool down after the session.
  • Train for a new sport before you start it. Start building strength and flexibility in the muscles you will use a few weeks or months in advance.
  • Learn the proper method/technique and use the proper equipment for any exercise or activity.
  • Work out regularly, not just once a week (4 to 5 days a week)
  • SLOWLY increase weight sizes (not more than 10% every 14 days)

 

Short note on Bursitis (Tennis/Golfers Elbow)

One of the primary reasons for tennis/golfers elbow is bad form/technique. The critical aspect that must be avoided is bending the wrist up or down when handling any weight. The wrist and hand must be 100% in a straight line with the forearm. The bending of the wrist inwards and outwards places severe stress on the elbow and it’s workings and is usually a primary cause for Bursitis.

 

Tips on how to deal with joint paint after exercise

  • Ice: The most straightforward solution is to apply ice to the affected joint. Immediately after an intense workout, put ice on your muscles and joints to prevent inflammation and speed up the healing process. However, ice will not solve everybody’s joint troubles.
  • Eat more raw vegetables: The vitamins and minerals in raw vegetables contain a number of helpful things that ease your joint pain. Designed specifically to fight the effects of muscle oxidation, natural vegetables are often your best option.
  • Avoiding painful exercises: Some workouts are more painful than others. Depending on your body’s shape, size, and flexibility, certain workouts could negatively affect your joints. If you haven’t been noticing significant gains from a specific workout, but have experienced joint pain, then you might want to cut that workout from your routine.

 

Supplements which treat joint pain
If bodybuilding is one of the most important things in your life, then you may want to consider taking a supplement to help ease your joint pain.

  • Omega 3 & 6 is a rather important supplement when dealing with joint pain. 3 tablets morning and 3 tablets evening usually sufficient. Also make sure you get enough good fat in – Peanut Butter, Avocado, extra virgin olive oil, etc…
  • Super Cissus has been show to help control joint pain. It is no wonder supplement but might help some to relief pain.
  • There is a natural substance found in high concentrations in our joint structures known as Glucosamine. Numerous double-blind studies have shown that Glucosamine produces better results in the treatment of joint pain than traditional drug therapy. The main function of glucosamine is to stimulate the manufacture of substances necessary for joint repair. Glucosamine is a well-tolerated, natural treatment. There have been no reported adverse reactions. In rare instances, some gastric discomfort was reported but was easily relieved by taking the supplement with food.
  • Other supplements worth trying: MSM and Chondroitin.
  • Deca Durabulin (an anabolic steroid) is available as a prescription from doctors for treating severe joint pain. It has great success (as many bodybuilders in the past can testify too) and is also a great lean muscle builder. So if you think you fall in this category – speak to your doctor and get the added benefit of muscle growth minus the pain.

 

Word of Warning

Any supplement (creatine for example) or anabolic steroid that enhances your power levels drastically with immediate effect will put you at severe high risk for joint problems. You might have the power now but your joints and tendons are not strengthened to deal with the power. Many, many anabolic steroid users run into this injury territory.

 

Wish you happy training and GROW. Cheers…

Gert Louw

GERT B&W

 


Click here to watch the video “Super supplement for pain relief revealed”

 

I will be making a few videos about a group of “super” supplements that stands out head and shoulders above the rest and which can make a massive difference in many people’s lives.

A little background: 10 years ago I was told by some doctors I have but a few years to live. I refused to accept that and started on my own journey of fitness and supplementation in an effort to built up and repair my broken body. As many know, this is now 10 years later and I look the best I’ve ever did in my life. In this article I want to share some of my knowledge.

When I was told my fate 10 years ago I did not had time to waste on mediocre supplement or stuff that make just marginal differences. If I add it to my critical list it need to make a huge difference, full stop.

One of these super supplements that made my critical list is Co-Enzyme Q10.

Apart from it’s legion of amazing benefits, scientific research studies are finally proving that it has a rather high degree of effectivity for fighting certain pains, particular migraines and Fibromyalgia. Some doctors even started to prescribe CQ10 to their migraine patients and report amazing results. Fibromyalgia sufferers, seems to be able to live a quality life again with the help of CQ10. They do not report a complete reduction of pain but enough to give them hope for a quality life.

Hiv + people and cancer sufferers has particularly low levels of CQ10 and for them it is an absolutely MUST TAKE supplement for such people.

 

What is it?

Coenzyme Q10 is a mitochondrial energizer that has shown remarkable effects against common heart ailments and neurological disorders. In just the past year, scientists have uncovered specific mechanisms indicating that CoQ10 may have a role in fighting certain cancers. Most surprising, however, are new studies that show how CoQ10 guards against a wide array of common age-related disorders. CoQ10 is naturally present in small amounts in a wide variety of foods, but levels are particularly high in organ meats such as heartliver, and kidney, as well as beef, soy oil, sardines, mackerel, and peanuts.

 

Some of the amazing benefits

(Extract from http://www.lef.org)

Preventing the Onset of Migraine

Migraine headaches are a debilitating, all-too-common affliction. Because mitochondrial dysfunction may play a role in migraines by limiting oxygen metabolism, researchers recently explored the use of CoQ10 in preventing these headaches. Published in the February 2005 issue of Neurology, the research describes a placebo-controlled trial of 42 patients in Switzerland.2

Patients who had suffered migraines for a year or more, with two to eight attacks per month, were randomly assigned to receive either 100 mg of CoQ10 or placebo, three times daily. At the end of the three-month trial, the CoQ10-treated group had lower attack frequency and fewer headache days and days with nausea than did the placebo group. The mean number of monthly migraine attacks dropped from 4.4 to 3.2 in the CoQ10 group, compared to a negligible decrease from 4.4 to 4.3 in the placebo group.2

In this study, supplemental CoQ10 reduced migraine frequency by 27%

 

Guarding the Brain After Cardiac Arrest

People who survive cardiac arrest often suffer irreversible brain damage as a result of the disruption of oxygen to the brain. European researchers recently investigated whether combining CoQ10 with mild hypothermia—a technique proven to reduce neuronal damage and increase survival—might enhance the effects of that treatment.1

Forty-nine patients who had suffered cardiac arrest and then received cardiopulmonary resuscitation were randomly selected to receive hypothermia (reduction of body temperature) treatment plus CoQ10 or hypothermia plus placebo. The hypothermia treatment involved the patients being placed on a body-surface-cooling mattress.

The patients were then administered either liquid CoQ10 (250 mg followed by 150 mg three times daily for five days) or a placebo through a nasogastric tube. The remarkable findings showed that three-month survival in the CoQ10 group was 68%, compared to only 29% in the placebo group. Coenzyme Q10 thus helped reduce the death rate from cardiac arrest by an astounding 57%. The researchers also found that 36% of patients in the CoQ10 group had a good neurological outcome at three months, versus only 20% in the placebo group.1

 

Slowing Early Macular Degeneration

Age-related macular degeneration is the most common cause of vision loss in people over 60.3 With the deterioration of the macula (a tiny cluster of highly specialized cells in the retina) central vision progressively begins to blur. As the disease worsens, central vision loss may increase until it becomes impossible to perform tasks that require detailed vision, such as driving and reading.

In recent years, researchers have focused on how oxidative damage affects age-related macular degeneration. The eye, one of the body’s most metabolically active organs, not only generates an enormous amount of free radicals through normal function, but also incurs additional oxidative damage from ultraviolet radiation and air pollution. In recent trials, the use of antioxidants has been shown to counter age-related macular degeneration. For example, in an 11-center, double-blind clinical trial conducted by the National Eye Institute (a division of the National Institutes of Health), a combination of antioxidants plus zinc slowed macular degeneration progression in people with intermediate or advanced disease by about 25%.4

Hungarian scientists are now exploring a metabolic rather than an antioxidant approach to managing macular degeneration. Citing findings that mitochondrial dysfunction might also play a role in the development of the disease, the researchers designed a clinical trial to evaluate intervention in early age-related macular degeneration with a combination of compounds—including CoQ10—that have demonstrated the ability to improve mitochondrial metabolism. The researchers reported results of their double-blind, placebo-controlled trial last year in the journal Opthalmologica.5 More than 100 patients with early age-related macular degeneration were randomly assigned to receive either two capsules per day containing 200 mg of acetyl-L-carnitine, 780 mg of omega-3 fatty acids, and 20 mg of CoQ10, or capsules containing an equal quantity of soy oil.

At the end of the 12-month treatment period, the researchers found statistically significant improvement in the treatment group as measured by all four parameters of visual function studied. In addition, only one of the 48 patients (2%) in the treatment group showed clinically significant worsening in visual field mean defect (blind spots in the visual field), the primary study endpoint, compared to 9 of 53 patients (17%) in the placebo group. The decrease in drusen—tiny yellow retinal deposits associated with macular degeneration—of the treated eyes was also statistically significant compared to placebo when either the most-affected eyes or the less-affected eyes were considered. In the less-affected eyes, the drusen-covered area decreased by 23% in the treated group, but increased by 13% in the placebo group. These findings suggest that intervention with an appropriate combination of nutrients that affect mitochondrial lipid metabolism may stabilize and even improve visual functions in early age-related macular degeneration.5

 

New Applications in Fighting Cancer

Research on CoQ10 and cancer has focused on two lines of inquiry: CoQ10’s ability to improve immune response and its ability to decrease the cardiotoxicity caused by a common class of anti-cancer chemotherapeutic agents.

 Patients with cancer often exhibit low levels of CoQ10

Based on these findings, Danish researchers investigated CoQ10’s effects alone and in combination with other nutrients as an adjunctive therapy for breast cancer.

In one case report, the researchers describe three breast cancer patients with metastasized cancer. The women underwent conventional cancer treatment and supplemented with a daily dose of 390 mg of CoQ10. All three women demonstrated tumor regression and decreased incidence of metastasis.9

In another study, the same research team investigated 32 high-risk breast cancer patients whose malignancy had spread to the lymph nodes.10 In addition to conventional therapeutic interventions, this group of patients received a daily combination of nutrients (vitamin C: 2850 mg; vitamin E: 2500 IU; beta-carotene: 32.5 IU; selenium: 387 mcg; and secondary vitamins and minerals), essential fatty acids (1.2 grams of gamma linolenic acid and 3.5 grams of omega-3 fatty acids), and 90 mg of CoQ10. At the end of the 18-month trial, six patients showed apparent partial remission, none of the patients showed signs of additional metastases, and their quality of life improved. None of the patients died during the study period, though four deaths were expected based on the patients’ disease stage. In one of the six patients with partial remission, the dose of CoQ10 in the nutritional protocol was increased to 390 mg. After two months, that patient’s tumor had disappeared completely, as confirmed by a mammogram.10

While chemotherapy drugs can be highly effective, their use can also be limited by toxic side effects. This has been noted in the case of anthracyclines, a class of drugs widely used in cancer chemotherapy. These drugs have demonstrated efficacy in the treatment of leukemia, lymphomas, and solid malignancies, and are often used to treat breast cancer, with higher doses yielding greater clinical responses. These higher doses of anthracyclines, however, can produce toxic effects on heart tissue, possibly leading to cardiomyopathy and heart failure that are not responsive to conventional pharmacological interventions.11 In fact, anthracyclines selectively damage mitochondria in the heart, but not in other organs.11 Since coenzyme Q10 supports both heart tissue and mitochondria, researchers conducted human trials to determine whether CoQ10 might prevent cardiotoxicity during the administration of anthracyclines.12

Two recent review articles addressed CoQ10’s potential as an adjunctive therapy during chemotherapy with anthracyclines. Writing in the Journal of Clinical Oncology, researchers summarized five reviewed studies in which CoQ10 was given along with anthracyclines.12 They report that in three of the studies that measured heart rhythm, patients who received CoQ10 showed favorable changes suggesting that CoQ10 might have a stabilizing effect on the heart. They also note that supplementation did not interfere with anthracycline treatment, and that no adverse effects were reported in any of the trials. The authors concluded that although coenzyme Q10 demonstrates potential for reducing cardiotoxicity, larger and more rigorous investigations are needed.

In 1961, scientists saw that people with cancer had little CoQ10 in their blood. They found low CoQ10 blood levels in people with myeloma, lymphoma, and cancers of the breastlungprostate,pancreascolonkidney, and head and neck. Some research has suggested that CoQ10 helps the immune system and may be useful as a secondary treatment for cancer.

  • CoQ10 may keep the antitumor drug doxorubicinfrom hurting the heart.
  • Three studies examined the use of CoQ10 along with conventional treatment for cancer. The three studies contained a total of 41 women with breast cancer. In each study, the women improved.

Slowing Neurodegenerative Disease Progression

Many investigators have conducted preclinical studies examining how oxidative stress and impaired mitochondrial function may contribute to neuronal cell death, a characteristic of Parkinson’s, Alzheimer’s, and other neurodegenerative diseases.13-17 For example, a recent journal article in Toxicology and Applied Pharmacology reported on the effects of the herbicide paraquat on neuronal cell death in the laboratory.17 The researchers found that this toxic chemical damaged mitochondria and increased free radical production, eventually resulting in the death of neuronal cells. Pretreatment of the cell cultures with CoQ10, however, inhibited both mitochondrial dysfunction and free radical generation.17 The researchers postulated that coenzyme Q10 may prove useful in preventing and treating neurodegenerative conditions related to environmental toxins.

While published research on the use of CoQ10 in slowing the progression of Alzheimer’s disease has been limited to preclinical studies, investigations of CoQ10 and Parkinson’s disease have moved into clinical trials, including randomized controlled studies. This work has been led by Clifford Shults, MD, professor of neurosciences at the University of California at San Diego School of Medicine. In Parkinson’s disease, brain cells that produce the neurotransmitter dopamine progressively die. Research in animals has shown that CoQ10 can protect the substantia nigra, the area of the brain where these cells reside. Studies by Dr. Shults and others have shown that mitochondrial dysfunction and diminished mitochondrial CoQ10 levels frequently occur in Parkinson’s sufferers.18

With funding from the National Institute of Neurological Disorders (a division of the National Institutes of Health), Dr. Shults and his colleagues undertook the first double-blind, placebo-controlled, multicenter clinical trial of CoQ10 in patients with early untreated Parkinson’s disease. In this phase II, dose-finding study, 80 patients were randomly assigned to receive one of three different CoQ10 doses (300 mg/day, 600 mg/day, or 1200 mg/day) with vitamin E, or a placebo containing vitamin E alone. The patients were followed for 16 months or until the participants required levodopa, a standard drug treatment for managing disease symptoms.19

The results, reported in the Archives of Neurology, showed that patients who received the largest dose of CoQ10 (1200 mg/day) had 44% less decline in mental function, movement, and ability to carry out activities of daily living than those who received the placebo.19 Patients who received CoQ10 doses of 300 mg/day and 600 mg/day also showed some slowing in decline compared to the placebo group, but not as much as those who took the highest dose. The authors concluded that CoQ10 was safe and well tolerated at doses up to 1200 mg/day.

Most recently, Dr. Shults and his team conducted an open label trial in which 17 patients were given an escalating dose of CoQ10 (1200 mg/day, 1800 mg/day, 2400 mg/day, and 3000 mg/day) combined with a stable dose of 1200 IU/day of vitamin E over a two-month period.20 They found that CoQ10 was well tolerated at high doses, but plasma levels of CoQ10 did not continue to rise when the dose was increased from 2400 to 3000 mg/day. There was no significant change in motor abilities in these Parkinson’s disease patients, some of whom were concurrently taking medications for the disease. Based on these findings, the researchers recommended conducting a phase III study to investigate the longer-term effect of high doses on previously untreated patients.

“Our [phase III] study will compare a placebo with 1200 mg/day and 2400 mg/day of CoQ10 and will enroll 200 subjects with early untreated disease in each treatment arm,” Dr. Shults told Life Extension in an exclusive interview. “The study . . . will probably take four years, with the results published a year later,” he added. In addition to that study, the National Institute of Neurological Disorders and Stroke is currently investigating the effects of a 2400-mg/day dose of CoQ10 in patients with early, untreated Parkinson’s disease.18

A clinical trial has also been undertaken in patients with Huntington’s disease, a neurodegenerative genetic disorder. This trial, conducted by the Huntington Study Group, randomly assigned 347 patients with Huntington’s disease to receive CoQ10 at 600 mg/day, remacemide hydrochloride at 600 mg/day, a combination of both, or placebo. Over the 30-month trial, the CoQ10 treated patients showed a 13% decrease in overall functional decline and beneficial trends in some secondary measures. However, the difference between the CoQ10 group and the other groups did not reach statistical significance.21

 

Other Potential Applications

In recent months, scientists have uncovered a widening array of applications for coenzyme Q10. According to new studies, CoQ10 may:

Protect against hearing loss. Mitochondrial DNA mutation is one cause of sensorineural hearing loss, a condition that causes changes in the inner ear or nerve pathways and is not correctable through medical interventions.23 In individuals with genetically based sensorineural hearing loss, coenzyme Q10 supplementation prevented further loss of hearing, while the control that did not supplement demonstrated continued deterioration of hearing function.

Improve learning. Supplementation with vitamin E and coenzyme Q10 helped a group of older mice to learn tasks more quickly than mice supplemented with only one of the two antioxidants.24 These findings suggest that coenzyme Q10 and vitamin E act in concert and may together help prevent age-related deficits in cognitive function.

Extend life span. In animals fed a diet enriched with polyunsaturated fatty acids, supplementing with coenzyme Q10 increased life span and protected against DNA alterations. Scientists recently determined that CoQ10 supplementation may confer these benefits by attenuating the decline in naturally occurring antioxidants that commonly accompanies aging.25

Prevent cachexia. The combination of coenzyme Q10 with vitamins B2 (riboflavin) and B3 (niacin) offers promise in preventing the weight loss and muscle wasting associated with cancer. In cancer, mitochondrial energy production is diminished, which may ultimately lead to the fatigue, weight loss, and muscle loss known as cachexia. In rats with experimentally induced breast cancer, supplementation with the energy-modulating nutrients B2, B3, and CoQ10 helped restore mitochondrial energy production, suggesting that this nutrient combination may help prevent cachexia.26

Assist muscle regeneration. Supplementing with coenzyme Q10 and vitamin E supported muscle regeneration in animals with experimentally induced muscle decay. The investigators noted that CoQ10 exerted a greater influence on muscle regeneration than did vitamin E.27

Protect against surgical stress. Supplementing with 300 mg of CoQ10 daily for two weeks prior to heart surgery boosted measures of heart muscle health, investigators recently noted. When heart muscle samples of the supplemented individuals were analyzed following elective surgery, this tissue exhibited improved energy production, decreased oxidative stress, and enhanced recovery from oxygen depletion compared to tissue samples from unsupplemented patients.28

Promote male fertility. Coenzyme Q10 supplementation for six months improved asthenozoospermia (reduced sperm motility) in infertile men.29 In an earlier study, administering a CoQ10 analog to men led to significant increases in both sperm count and motility.30 These findings suggest that CoQ10 may help improve defective sperm function, a common and difficult-to-treat cause of male infertility.

Protect against senile plaques. A laboratory study demonstrated CoQ10’s ability to destabilize amyloid beta peptides, a hallmark abnormality of Alzheimer’s disease.31 This suggests a further potential neuroprotective mechanism of coenzyme Q10.

Impede diabetic complications. An animal study has shown that CoQ10 displays potential for preventing complications associated with diabetes.32

Lower triglycerides. The results of an Italian preliminary clinical trial suggest that the combination of CoQ10 and fibrate drugs may benefit individuals with exceedingly high levels of triglycerides who fail to respond to fibrates alone.33

Summary

The latest findings suggest that, along with its heart-protective effects, CoQ10 may slow or improve some degenerative diseases, support cancer remission, counteract the toxic effects of chemotherapy, and decrease the incidence of migraine headaches. Additionally, recent findings indicate that coenzyme Q10 may have applications in promoting fertility, protecting auditory function, supporting longevity, boosting learning capability, sustaining muscle health and much more.

CoQ10 investigations are expanding into new areas, and researchers are now calling for larger, well-designed studies to support intriguing findings from small and observational trials. With CoQ10’s pervasiveness in the body and the many essential functions it performs, scientists will no doubt continue to elucidate this vital nutrient’s many potential applications.

DYNAMIC DUO: COQ10 AND VITAMIN E
In addition to its direct scavenging of free radicals, CoQ10 also helps regenerate vitamin E, another important antioxidant. Vitamin E provides antioxidant protection in fat-soluble environments such as cell membranes.18 When coenzyme Q10 levels in cell membranes are diminished, regeneration of vitamin E is slowed as well.22

Is CoQ10 safe?

Taking 100 mg a day or more of CoQ10 has caused mild insomnia in some people. And research has detected elevated levels of liver enzymes in people taking doses of 300 mg per day for long periods of time. Liver toxicity has not been reported.

Other reported side effects include rashesnausea, upper abdominal paindizziness, sensitivity to light, irritability, headacheheartburn, andfatigue.

Medicines for high cholesterol (statins) and medicines that lower blood sugar cause a decrease of CoQ10 levels and reduce the effects of CoQ10 supplements. CoQ10 can reduce the body’s response to theblood thinner (anticoagulant) medicine warfarin (Coumadin) and can decrease insulin requirements in people with diabetes.

The U.S. Food and Drug Administration (FDA) does not regulatedietary supplements in the same way it regulates medicines. A dietary supplement can be sold with limited or no research on how well it works or on its safety.

 

This information is not intended to replace the advice of a doctor. http://www.gertlouw.com disclaims any liability for the decisions you make based on this information.

 

References
1. Damian MS, Ellenberg D, Gildemeister R, et al. Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study. Circulation. 2004 Nov 9;110(19):3011-6.2. Sandor PS, Di CL, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology. 2005 Feb 22;64(4):713-5.3. Available at: http://www.nei.nih.gov/health/maculardegen.armd_facts.asp#1. Accessed November 16, 2005.4. Anon. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001 Oct;119(10):1417-36.

5. Feher J, Kovacs B, Kovacs I, et al. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica. 2005 May;219(3):154-66.

6. Folkers K, Osterborg A, Nylander M, Morita M, Mellstedt H. Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. Biochem Biophys Res Commun. 1997 May 19;234(2):296-9.

7. Portakal O, Ozkaya O, Erden IM, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem. 2000 Jun;33(4):279-84.

8. Folkers K, Morita M, McRee J, Jr. The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem Biophys Res Commun. 1993 May 28;193(1):88-92.

9. Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun. 1995 Jul 6;212(1):172-7.

10. Lockwood K, Moesgaard S, Hanioka T, Folkers K. Apparent partial remission of breast cancer in ‘high risk’ patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med. 1994;15 Suppls231-s240.

11. Conklin KA. Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity. Integr Cancer Ther. 2005 Jun;4(2):110-30.

12. Roffe L, Schmidt K, Ernst E. Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review. J Clin Oncol. 2004 Nov 1;22(21):4418-24.

13. Somayajulu M, McCarthy S, Hung M, et al. Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis. 2005 Apr;18(3):618-27.

14. Sohmiya M, Tanaka M, Tak NW, et al. Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson’s disease. J Neurol Sci. 2004 Aug 30;223(2):161-6.

15. Menke T, Gille G, Reber F, et al. Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential. Biofactors. 2003;18(1-4):65-72.

16. Shavali S, Carlson EC, Swinscoe JC, Ebadi M. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells. J Neurosci Res. 2004 May 15;76(4):563-71.

17. McCarthy S, Somayajulu M, Sikorska M, Borowy-Borowski H, Pandey S. Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10. Toxicol Appl Pharmacol. 2004 Nov 15;201(1):21-31.

18. Shults CW. Therapeutic role of coenzyme Q(10) in Parkinson’s disease. Pharmacol Ther. 2005 Jul;107(1):120-30.

19. Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002 Oct;59(10):1541-50.

20. Shults CW, Flint BM, Song D, Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp Neurol. 2004 Aug;188(2):491-4.

21. Anon. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington’s disease. Neurology. 2001 Aug 14;57(3):397-404.

22. Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001 Dec;20(6):591-8.

23. Angeli SI, Liu XZ, Yan D, Balkany T, Telischi F. Coenzyme Q-10 treatment of patients with a 7445A—->G mitochondrial DNA mutation stops the progression of hearing loss. Acta Otolaryngol. 2005 May;125(5):510-2.

24. McDonald SR, Sohal RS, Forster MJ. Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice. Free Radic Biol Med. 2005 Mar 15;38(6):729-36.

25. Bello RI, Gomez-Diaz C, Buron MI, et al. Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp Gerontol. 2005 Aug;40(8-9):694-706.

26. Perumal SS, Shanthi P, Sachdanandam P. Energy-modulating vitamins—a new combinatorial therapy prevents cancer cachexia in rat mammary carcinoma. Br J Nutr. 2005 Jun;93(6):901-9.

27. Otrocka-Domagala I, Rotkiewicz T, Karpinska J, et al. The effect of coenzyme Q10 and vitamin E on the regeneration of skeletal muscles in pigs. Pol J Vet Sci. 2004;7(4):295-303.

28. Rosenfeldt F, Marasco S, Lyon W, et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. J Thorac Cardiovasc Surg. 2005 Jan;129(1):25-32.

29. Balercia G, Mosca F, Mantero F, et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004 Jan;81(1):93-8.

30. Anon. Coenzyme Q10. Altern Med Rev. 1998 Feb;3(1):58-61.

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Happy training everyone!

Gert Louw

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Click here to PLAY video “BOOST energy and immune system in one go!”

 

Before I even talk about training aspects, let me first take you down the road my wife was the past few years. She had severe restless legs syndrome and were continuously fatigued. Those that have severe restless legs syndrome will know that it can drive one crazy!

After many prescribed medications was tried, I got here to do some extensive blood-work tests.

A surprise was that she had very low magnesium levels in her blood.

Immediately the light went on! Magnesium plays a crucial factor in various muscle related functions as well as energy and ATP related functions in the body. It even have an impact on the nervous system and skeletal bone maintenance.

She was put on high dosage slow released magnesium supplements and within just a few days her restless legs syndrome disappeared. For her it was like a miracle. Her energy levels also drastically increased.

Slow Mag is now part of her daily supplementation.

This is a mineral that is so underrated. By far the greatest majority (in excess of 70%) of people is deficient of magnesium.

For the bodybuilder, a magnesium deficiency presents a big problem:

  • He WILL struggle to build muscle, feel fatigued and energy less continuously.
  • Being deficient will even result in an immune system being under pressure, thus further impact on available gym time. Thus also why critically important that any hiv+ person must make sure he/she supplement with slow mag.
  • Athletes and bodybuilder need more nutrients than less active people. So it will be a given that you will require supplementation of magnesium.
  •  Magnesium further helps the bodybuilder to reduce the accumulation of lactic acid and reducing the perception of fatigue during heavy training.
  • Magnesium even helps lowering the blood pressure resulting in healthier kidneys and heart.

To sum it up, the bodybuilder will struggle severely to build muscles when magnesium deficient. He will be regularly sick due to compromised immune system, more prone to become diabetic and have a much higher risk for heart disease. His energy levels will be severely compromised and he will feel on edge the whole time…and much more!

Extract from http://www.livestrong.com:

“If your diet consistently falls short on magnesium, the resulting chronically low levels can increase your risk of cardiovascular disease, high blood pressure, osteoporosis and Type 2 diabetes, according to the Office of Dietary Supplements. A significant association exists between the amount of magnesium you consume and your overall risk for cardiovascular disease, reported a review in PLoS One in March 2013. Getting enough magnesium in your diet also helps lower inflammation, which may fight health conditions accompanied by inflammation, such as diabetes and heart disease, according to a review in the February 2014 issue of the European Journal of Clinical Nutrition.”

Magnesium plays a key role in hundreds of cellular processes, from metabolizing food into energy and absorbing calcium to maintaining a strong immune system and keeping your heart, muscles, and nerves functioning properly.

Magnesium relaxes muscles and is anti-inflammatory. This mineral also has a laxative effective, so it can help relieve constipation. Magnesium has also been found to have a protective effect against stress. Take 200 to 300 milligrams per day of the mineral magnesium (unless you have kidney problems or you’re prone to diarrhea).

Extract from http://www.organicfacts.net:

Prevents Asthma – Patients that suffer from chronic asthma may be able to normalize their breathing with the help of magnesium supplements that aid in relaxing the bronchial muscles and regulating breathing. Even wheezing and breathlessness can be relieved through administration of intravenous magnesium.

Keeps bones healthy – Magnesium is directly related to bone density, and subsequently, an inadequacy of this mineral in the body can be a cause of osteoporosis. Magnesium helps in the regulation of calcium levels in the body, along with vitamin D, copper, and zinc. Magnesium, along with calcium and Vitamin D, should be taken throughout the developmental years and adulthood, since it eliminates the chances of developing osteoporosis when you get older.

Essential during pregnancy – Magnesium is one of the vital elements to ensure a healthy pregnancy. Proper intake of magnesium supplements during pregnancy is extremely beneficial for reducing the risk of osteoporosis and increasing the pain tolerance level, thereby resulting in a smooth delivery process and an optimization of blood pressure. Magnesium sulfate is the best treatment for preventing eclamptic seizures in expectant mothers who may have hypertension.

Treats back pain and cramps – Magnesium helps treating people with severe backaches by relaxing back muscles, kidney stress and muscular tension. As mentioned earlier, magnesium also helps in the body’s absorption of calcium, which may lead to faster healing of the bones. Symptoms of cramps in the legs, as well as general fatigue are traditional symptoms of magnesium deficiency. Therefore, proper intake of magnesium supplements acts as a cure for chronic leg cramp problems.

Prevents constipation – Magnesium provides quick relief from constipation, and a high dose of water-soluble magnesium supplements is known to bring sound relief for even the most severe constipated state. This laxative property of magnesium relaxes the intestinal muscles, thereby helping to establish a smoother rhythm while passing bowels. Magnesium also has another property of attracting water, which in turn softens the stool and helps it to pass easily.

Prevents diabetes and regulates sugar level – The health benefits of magnesium extend to diabetic patients also, as this mineral helps to regulate the insulin reaction to blood sugar levels. Magnesium supplements are vital for all diabetic patients as many of them suffer from magnesium deficiency. Magnesium aids in regulating blood sugar status, thus promoting normal blood pressure. Hypertension is one of the major reasons for an impending heart attack, and it has been found that many people with high blood pressure also have a magnesium deficiency. Therefore, extra nutrients and mineral supplements with magnesium content are vital in order to avoid any medical complications.

Cures psychiatric disorders – Magnesium is known to cure some of the worst forms of psychiatric dysfunctions such as panic attacks, stress, anxiety and undue agitation.

Cures migraines – Migraine attacks badly affect many Americans, especially, females.  Magnesium supplements and liquids considerably reduce the severity of such attacks and may also help in reducing the rate of recurrence.

Produces collagen –Magnesium is important for producing proteins that are slowly transformed into collagen. Collagens are naturally occurring proteins mostly found in fibrous tissues like tendons, ligaments and the skin. It is also present in the cornea, bones, the gut, cartilage, blood vessels, and intervertebral discs. The more collagen in the system, the stronger those areas of the body will become.

Absorb minerals –Magnesium helps to absorb vital vitamins and minerals like sodium, calcium, potassium and phosphorus. Mineral absorption usually occurs within the small intestine and this benefit of magnesium ensures the detoxification of many harmful toxins in our body.

Activates enzymes – Magnesium also helps to boost the energy production in the body and it promotes theactivation of enzymes to create cellular energy.

Controls bladder functions – Many people who have blabber problems and suffer from the frequent urge to urinate may find relief by taking magnesium supplements. Urination problems can come from a variety of reasons such as nephritis, infections, or sometimes interstitial cystitis; however, regular intake of magnesium can bring great relief to these ailments.

Happy training!

GertFITNESS

50th birthday studio COVER

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