Tag Archive: CQ10



Over 40 training and joint pain – what to do?

Click here to watch video “Over 40 Ultimate guide for dealing with join pains”

This is very familiar territory for every over 40 guy. We nearly all struggle with joint and tendon pains.

Some of us accept defeat and enter potbelly territory. Well if are you like me, then we refuse to accept even the word “defeat”. It is not in our vocabulary.

But we cannot ignore the aches and pains. So how do we deal with it?

First, the fact is, it IS good, very good, for the over 40 body to be involved in resistance training. That has been proven beyond any doubt by many science studies.

We must just find a way of dealing with the “problem” and not too simply, give up! Dealing with it involves wisdom and quite a few things that we need to do to effectively relief the pain.

Before we start discussing what must be done, remember – NEVER train through pain. You will make whatever the problem is MUCH worse. As you get older you will have to regularly change your exercises and even your whole workout approach and regimen to periodically side-step pains and aches in tendons, joints and back. This is a given. BUT…never, ever, stop training because of pain…adapt and change. Always keep training with what you can do, even if it means a total different temporary training approach.

Joint pain (and tendon pain) is not just simply a result of training heavy. MANY factors play a role.

Let’s go through the list of the things you need to do to relief/avoid tendon/joint pain:

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TRAINING

  1. You must have a cutting (lighter weights, higher reps per set) and building (lower reps with higher weights) phase in place to allow regular “rest” periods for the tendons/joints. Phase lengths should be roughly 3 months each.
  2. Consider training lighter for a 6-month to a year period if you struggle with a serious tendon/joint issue.
  3. Very important – never bend your hand upward or downward when lifting, but keep it all times in a straight line with the for-arm. Bending the hand during heavy lifting places undue strain on the elbow via strained tendons. Keeping the hand straight keep all tendons at equal strain.
  4. Bench pressing should be performed with the overhand position with bar resting on the thumb area (bottom) of the palm so that there is no pressure on the wrist. (The place where the bar lies on the hand must be in a straight line with the whole arm to ensure that no strain is on wrist.)
  5. Use special straps to relief strain on the wrist. I will show example in the video. A simple strap fastened around the wrist with a rubber palm grip which can be wrapped around heavy weights. This allows for near zero strain on the wrist joint. This is especially helpful with pull ups, shrugs and nearly all back and upper body exercises.

 

LIFESTYLE

  1. Yip you guessed it…NO SMOKING! Smoking makes the whole body functioning less optimally. It affects nearly everything in the body from the brain to the skin to the lungs to pains and aches that get much worse because of the smoking.
  2. The same goes for drinking. Light drinking (4 glasses wine per week) is max. But even for some this proves to be too much and result in joint pain. In quite a few cases people had to completely stop drinking alcohol in an attempt to get rid of the joint pains.
  3. Too little sleeping. Your body needs time to heal and repair. Too little sleeping rob it of this time. A good (6-8hrs) night rest will go a long way to help the body function optimally.

 

EATING

Our eating habits have a much bigger role to play in joint pain than you might think.

  1. Ensure that you drink enough filtered water per day (3L-6L). This helps washing out the toxins from the body. More toxins = more joint pain.
  2. Enough good oils. Apart from the fact that good oils (omega 3 & 6: peanut butter, olive oil, avocado, coconut) are critical for a healthy functioning hormonal system, it is also very important to help ease joint pain. Cutting out all good oils/fat from your diet will aggravate joint pain and result in low testosterone levels.
  3. You must ensure the body is in an alkaline environment with a PH of roughly 7. The more acidic the body gets, the more joint pain will be experienced, full stop. There are enough serious science studies to back this up. There are also many other advantages when you keep the body in an alkaline state. It has been proven to lessen your risk for cancer and supports a stronger immune system amongst others. On the next page there is a list of ALKALINE and ACIDIC foods to help you adjusting your diet. (A good starting point – lemon juice every morning and evening and cutting out wine and fizzy drinks. MANY people have gotten rid of their joints pains by simply changing their diet to a more alkaline one.)

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SUPPLEMENTS (natural)

  1. CQ10 (Co-Enzyme Q10). This has been proven by various science studies to be a potent long term pain combatant. However, as with most natural approaches, this only starts working after more than 1 month of continuous usage. [I take 300mg in morning and 300mg at night.]
  2. Even more potent than CQ10, MSM (METHYLSULPHONYLMETHANE) has helped many people changing their lives. It is not a wonder pill but with long term use can significantly ease joint pain. Effective results only achieved after about 3-4 months of continuous use. [I take 400mg morning and 400mg evening]
  3. The 3rd one, eish…this took me some time to support it’s use – CANNABIS oil. I am old school and anything drug-related, even for medical reasons is pretty much “no-go” territory for me. This one took some serious mind changing for me. Eventually I just could not ignore study after study that supported various benefits of CANNABIS OIL. The oil, which contains a higher ratio CBD to THD, is rather harmless when compared to the psychotropic effects of smoking cannabis. It is the THD that result in all this bad effects and the oil has a CBD/THD blend of about 85/15 in most cases which make it mostly harmless. Even here in South Africa the studies are nearly concluded and it looks like we are mere months away from Cannabis Oil being available over the counter for medical purposes. Apart from lowering blood pressure, combating nausea, helping with sleep and fighting cancer, it is actually a potent pain relief substance. 250-raw-cbdAfter about 3 weeks use the body reach a saturation point and then the real pain relieving properties kicks in. If you can get past the mind barrier of taking something that is closely drug related then this could have a drastic positive pain relief impact. And believe me it is not so easy getting past this “mind barrier” for us older folks…but it can be done…I took the plunge. The end result for me – less pain and drastic better sleeping at night. Also drastically lower blood pressure. [I take 1 drop morning, 1 drop afternoon and 5 drops before bed]. Cannabis oil (CBD/THD) has some very interesting medical applications. Some of the claims the cannabis groupies make is not backed up at all by science but some actually are, especially with the latest studies. I think this warrant a future article to give some more insight into this new emerging product (emerging…well at least in the medical mainstream community that is!).

 

MEDICATION

This is a territory you want to avoid. Yes, you can take anti-inflammatory meds, but this is hard on kidneys/liver/stomach and definitely NOT a long term solution.

The last resort and sometimes a necessary route is arthritis medication. There are various types depending on the severity and type of arthritis. A well know anabolic steroid, Deca-Durabolin, is known for its anti-arthritis / joint pain properties. But only your health care provider can do the necessary blood test to determine the problem and plan of action.

However most of the time if you take the points above about training, lifestyle, diet and supplementation seriously enough then you can have pain free over 40+ workouts.

Interested in my customized transformation system for the over 40 guy? Have a look here:  https://gertlouw.com/my-transformation-secrets/

Happy training everybody!

Cheers

Gert Louw

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Please click here to watch video “CUTTING EDGE SUPPLEMENTS AGAINST PAIN AND CANCER”

When one reaches over 40 and especially over 50 then there are two major concerns that becomes reality for many, constant daily pain and for some the dreaded cancer!

All is not lost. Well for some it is…when one continue on an unhealthy living path (smoking, drinking, and no exercise) well, then the future unfortunately looks a bit bleak.

But just the other day I met a 92 y/o guy, fit, very mobile, with it! So certain things can be done to limit your risks and enhance your quality life.

However even if you do that, constant pain in joints/muscles seems to be part of any person over 40’s life. And so does the possibility of getting cancer.

We use to think it is just by the “throw of a dice” luck that we do not get cancer. But alas, there might just be a way out! Yes you hear right there just might be a very (!) powerful tool in your arsenal that limits your risk for cancer DRASTICALLY.

The same goes for the constant pain. There are 2 weapons in your arsenal to fight this rather effectively.

But first, let’s lay the basic groundwork.

Alpha Lipoic Acid & Potent Multi Vitamin

Two health supplements that form the basis of good health is a good/potent multi vitamin and ALPHA LIPOIC ACID. The best two choices for a potent multi vitamin is OPTIMEN or ANIMAL PAK.

Take the multi vit as directed on the container (must be after meal).

Why the multi vit – well simple you need to ensure that all the basis are covered concerning vitamins and minerals. Just short of one of these can have real bad consequences. This is very important for the older individual. You CANNOT rely on your food to get everything in.

Alpha Lipoic Acid must be taken at 200mg after morning meal and after evening meal.

Why Alpha Lipoic Acid?

Based on evidence from animal and human studies, lipoic acid offers the following essential health benefits:

  • Reduces oxidative stress in the body via powerful antioxidant activity
  • Improves several components of the metabolic syndrome—a combination of risk factors that increases one’s risk for diabetes
  • Reduces blood pressure
  • Reduces insulin resistance
  • Improves the lipid profile
  • Reduces weight
  • Increases insulin sensitivity
  • Improves diabetic neuropathy
  • Protects against cataract formation
  • Improves visual function in glaucoma
  • Helps prevents retinal cell death when combined with vitamin E in retinitis pigmentosa
  • Reduces brain damage after a stroke
  • Prevents bone loss, possibly through an anti-inflammatory effect
  • Removes toxic metals from the body
  • Reduces frequency and intensity of migraines
  • Improves skin texture

Now on to powerful pain relievers (although Alpha Lipoic Acid also play a role to relief pain).

MSM (Methylsulfonylmethane)

The first one is MSM. Now you might have heard about it. But the truth is, IT DOES WORK. But, not immediately. It is not like popping a pain-pill. It is more like reprogramming your body first before it takes effect.

Some of the most common uses for MSM include treating:

  • chronic joint pain (osteoarthritis, joint inflammation, rheumatoid arthritis)
  • leaky gut syndrome and autoimmune disorders
  • osteoporosis and susceptibility to bone fractures
  • bursitis, tendonitis, the development of scar tissue and other musculoskeletal pains
  • allergies and asthma
  • yeast infections
  • muscle cramps
  • constipation, ulcers, upset stomach, indigestion
  • PMS symptoms (cramps, headaches, water retention, indigestion)
  • stretch marks
  • hair loss
  • skin problems including wrinkles, sun burns (it offers some protection against UV light/wind burn), wounds, cuts, skin abrasions
  • eye inflammation
  • poor circulation
  • high blood pressure
  • fatigue
  • oral infections, toothaches, gum disease/periodontal disease

Three uses that MSM has gained the most notoriety for include: acting like an anti-atherosclerotic (preventing the hardening/thickening of arteries), chemo-preventative compound and natural anti-inflammatory. MSM seems to help the body’s natural free radical-scavenging, which means it lowers oxidative stress as the many ailments that come along with it. It’s an effective anti-inflammatory because it blocks the release of pro-inflammatory mediators and down regulates certain harmful signals sent from the immune system that can affect the entire body.

According to the Arthritis Foundation, based on the most reputable studies conducted so far on MSM — such as a 2006 pilot study that analysed the effects of 6,000 milligrams of MSM taken daily by patients with osteoarthritis — it effectively helps improve symptoms of pain and physical function without any major side effects.

That being said, MSM is capable of causing mild side effects for some people, including indigestion, upset stomach or diarrhoea. It’s also not suitable for people taking blood-thinner medications. If you’re pregnant, you’ll want to speak with a doctor before taking it regularly.

Lastly, MSM does NOT start working immediately. It takes up to 3 months for it to start working effectively. For some up to 6 months. So although there is a considerable lead time…it really is worth investing in the long term in using MSM because it IS a powerful pain suppressant with many other health benefits.

Co Enzyme Q10

Now an even more interesting product, Co Enzyme Q10. [Suggested: 150mg after morning and evening meal]

I have written about this wonder supplement in the past and I consider it the “mother of all supplements”. None comes close to it in effectiveness and health boosting ability. And to top it off, it is a significant pain suppressant. To such an extent that many doctors are now at long last starting to subscribe CQ10 to their migraine patients.

Coenzyme Q10 is a mitochondrial energizer that has shown remarkable effects against common heart ailments and neurological disorders. In just the past year, scientists have uncovered specific mechanisms indicating that CoQ10 may have a role in fighting certain cancers. Most surprising, however, are new studies that show how CoQ10 guards against a wide array of common age-related disorders. In this article, we summarize recent discoveries that significantly broaden the clinical utility of CoQ10.

Guarding the Brain After Cardiac Arrest

People who survive cardiac arrest often suffer irreversible brain damage as a result of the disruption of oxygen to the brain. European researchers recently investigated whether combining CoQ10 with mild hypothermia—a technique proven to reduce neuronal damage and increase survival—might enhance the effects of that treatment.

Forty-nine patients who had suffered cardiac arrest and then received cardiopulmonary resuscitation were randomly selected to receive hypothermia (reduction of body temperature) treatment plus CoQ10 or hypothermia plus placebo. The hypothermia treatment involved the patients being placed on a body-surface-cooling mattress.

The patients were then administered either liquid CoQ10 (250 mg followed by 150 mg three times daily for five days) or a placebo through a nasogastric tube. The remarkable findings showed that three-month survival in the CoQ10 group was 68%, compared to only 29% in the placebo group. Coenzyme Q10 thus helped reduce the death rate from cardiac arrest by an astounding 57%. The researchers also found that 36% of patients in the CoQ10 group had a good neurological outcome at three months, versus only 20% in the placebo group.

Preventing the Onset of Migraine

Migraine headaches are a debilitating, all-too-common affliction. Because mitochondrial dysfunction may play a role in migraines by limiting oxygen metabolism, researchers recently explored the use of CoQ10 in preventing these headaches. Published in the February 2005 issue of Neurology, the research describes a placebo-controlled trial of 42 patients in Switzerland.

Patients who had suffered migraines for a year or more, with two to eight attacks per month, were randomly assigned to receive either 100 mg of CoQ10 or placebo, three times daily. At the end of the three-month trial, the CoQ10-treated group had lower attack frequency and fewer headache days and days with nausea than did the placebo group. The mean number of monthly migraine attacks dropped from 4.4 to 3.2 in the CoQ10 group, compared to a negligible decrease from 4.4 to 4.3 in the placebo group.

In this study, supplemental CoQ10 reduced migraine frequency by 27%.

Slowing Early Macular Degeneration

Age-related macular degeneration is the most common cause of vision loss in people over 60. With the deterioration of the macula (a tiny cluster of highly specialized cells in the retina) central vision progressively begins to blur. As the disease worsens, central vision loss may increase until it becomes impossible to perform tasks that require detailed vision, such as driving and reading.

In recent years, researchers have focused on how oxidative damage affects age-related macular degeneration. The eye, one of the body’s most metabolically active organs, not only generates an enormous amount of free radicals through normal function, but also incurs additional oxidative damage from ultraviolet radiation and air pollution. In recent trials, the use of antioxidants has been shown to counter age-related macular degeneration. For example, in an 11-center, double-blind clinical trial conducted by the National Eye Institute (a division of the National Institutes of Health), a combination of antioxidants plus zinc slowed macular degeneration progression in people with intermediate or advanced disease by about 25%.

Hungarian scientists are now exploring a metabolic rather than an antioxidant approach to managing macular degeneration. Citing findings that mitochondrial dysfunction might also play a role in the development of the disease, the researchers designed a clinical trial to evaluate intervention in early age-related macular degeneration with a combination of compounds—including CoQ10—that have demonstrated the ability to improve mitochondrial metabolism. The researchers reported results of their double-blind, placebo-controlled trial last year in the journal Opthalmologica. More than 100 patients with early age-related macular degeneration were randomly assigned to receive either two capsules per day containing 200 mg of acetyl-L-carnitine, 780 mg of omega-3 fatty acids, and 20 mg of CoQ10, or capsules containing an equal quantity of soy oil.

At the end of the 12-month treatment period, the researchers found statistically significant improvement in the treatment group as measured by all four parameters of visual function studied. In addition, only one of the 48 patients (2%) in the treatment group showed clinically significant worsening in visual field mean defect (blind spots in the visual field), the primary study endpoint, compared to 9 of 53 patients (17%) in the placebo group. The decrease in drusen—tiny yellow retinal deposits associated with macular degeneration—of the treated eyes was also statistically significant compared to placebo when either the most-affected eyes or the less-affected eyes were considered. In the less-affected eyes, the drusen-covered area decreased by 23% in the treated group, but increased by 13% in the placebo group. These findings suggest that intervention with an appropriate combination of nutrients that affect mitochondrial lipid metabolism may stabilize and even improve visual functions in early age-related macular degeneration.

New Applications in Fighting Cancer

Research on CoQ10 and cancer has focused on two lines of inquiry: CoQ10’s ability to improve immune response and its ability to decrease the cardiotoxicity caused by a common class of anti-cancer chemotherapeutic agents.

Patients with cancer often exhibit low levels of CoQ10,6,7 and researchers have shown that CoQ10 can increase immune response in humans.

Based on these findings, Danish researchers investigated CoQ10’s effects alone and in combination with other nutrients as an adjunctive therapy for breast cancer.

In one case report, the researchers describe three breast cancer patients with metastasized cancer. The women underwent conventional cancer treatment and supplemented with a daily dose of 390 mg of CoQ10. All three women demonstrated tumor regression and decreased incidence of metastasis.

In another study, the same research team investigated 32 high-risk breast cancer patients whose malignancy had spread to the lymph nodes. In addition to conventional therapeutic interventions, this group of patients received a daily combination of nutrients (vitamin C: 2850 mg; vitamin E: 2500 IU; beta-carotene: 32.5 IU; selenium: 387 mcg; and secondary vitamins and minerals), essential fatty acids (1.2 grams of gamma linolenic acid and 3.5 grams of omega-3 fatty acids), and 90 mg of CoQ10. At the end of the 18-month trial, six patients showed apparent partial remission, none of the patients showed signs of additional metastases, and their quality of life improved. None of the patients died during the study period, though four deaths were expected based on the patients’ disease stage. In one of the six patients with partial remission, the dose of CoQ10 in the nutritional protocol was increased to 390 mg. After two months, that patient’s tumor had disappeared completely, as confirmed by a mammogram.

While chemotherapy drugs can be highly effective, their use can also be limited by toxic side effects. This has been noted in the case of anthracyclines, a class of drugs widely used in cancer chemotherapy. These drugs have demonstrated efficacy in the treatment of leukemia, lymphomas, and solid malignancies, and are often used to treat breast cancer, with higher doses yielding greater clinical responses. These higher doses of anthracyclines, however, can produce toxic effects on heart tissue, possibly leading to cardiomyopathy and heart failure that are not responsive to conventional pharmacological interventions. In fact, anthracyclines selectively damage mitochondria in the heart, but not in other organs. Since coenzyme Q10 supports both heart tissue and mitochondria, researchers conducted human trials to determine whether CoQ10 might prevent cardiotoxicity during the administration of anthracyclines.

Two recent review articles addressed CoQ10’s potential as an adjunctive therapy during chemotherapy with anthracyclines. Writing in the Journal of Clinical Oncology, researchers summarized five reviewed studies in which CoQ10 was given along with anthracyclines. They report that in three of the studies that measured heart rhythm, patients who received CoQ10 showed favorable changes suggesting that CoQ10 might have a stabilizing effect on the heart. They also note that supplementation did not interfere with anthracycline treatment, and that no adverse effects were reported in any of the trials. The authors concluded that although coenzyme Q10 demonstrates potential for reducing cardiotoxicity, larger and more rigorous investigations are needed.

Slowing Neurodegenerative Disease Progression

Many investigators have conducted preclinical studies examining how oxidative stress and impaired mitochondrial function may contribute to neuronal cell death, a characteristic of Parkinson’s, Alzheimer’s, and other neurodegenerative diseases. For example, a recent journal article in Toxicology and Applied Pharmacology reported on the effects of the herbicide paraquat on neuronal cell death in the laboratory. The researchers found that this toxic chemical damaged mitochondria and increased free radical production, eventually resulting in the death of neuronal cells. Pretreatment of the cell cultures with CoQ10, however, inhibited both mitochondrial dysfunction and free radical generation. The researchers postulated that coenzyme Q10 may prove useful in preventing and treating neurodegenerative conditions related to environmental toxins.

While published research on the use of CoQ10 in slowing the progression of Alzheimer’s disease has been limited to preclinical studies, investigations of CoQ10 and Parkinson’s disease have moved into clinical trials, including randomized controlled studies. This work has been led by Clifford Shults, MD, professor of neurosciences at the University of California at San Diego School of Medicine. In Parkinson’s disease, brain cells that produce the neurotransmitter dopamine progressively die. Research in animals has shown that CoQ10 can protect the substantia nigra, the area of the brain where these cells reside. Studies by Dr. Shults and others have shown that mitochondrial dysfunction and diminished mitochondrial CoQ10 levels frequently occur in Parkinson’s sufferers.

With funding from the National Institute of Neurological Disorders (a division of the National Institutes of Health), Dr. Shults and his colleagues undertook the first double-blind, placebo-controlled, multicenter clinical trial of CoQ10 in patients with early untreated Parkinson’s disease. In this phase II, dose-finding study, 80 patients were randomly assigned to receive one of three different CoQ10 doses (300 mg/day, 600 mg/day, or 1200 mg/day) with vitamin E, or a placebo containing vitamin E alone. The patients were followed for 16 months or until the participants required levodopa, a standard drug treatment for managing disease symptoms.

The results, reported in the Archives of Neurology, showed that patients who received the largest dose of CoQ10 (1200 mg/day) had 44% less decline in mental function, movement, and ability to carry out activities of daily living than those who received the placebo.19 Patients who received CoQ10 doses of 300 mg/day and 600 mg/day also showed some slowing in decline compared to the placebo group, but not as much as those who took the highest dose. The authors concluded that CoQ10 was safe and well tolerated at doses up to 1200 mg/day.

A clinical trial has also been undertaken in patients with Huntington’s disease, a neurodegenerative genetic disorder. This trial, conducted by the Huntington Study Group, randomly assigned 347 patients with Huntington’s disease to receive CoQ10 at 600 mg/day, remacemide hydrochloride at 600 mg/day, a combination of both, or placebo. Over the 30-month trial, the CoQ10 treated patients showed a 13% decrease in overall functional decline and beneficial trends in some secondary measures. However, the difference between the CoQ10 group and the other groups did not reach statistical significance.

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METFORMIN

Now on to the last miracle supplement. Metformin [suggested 500mg daily]

This is actually not a supplement but a prescribed medicine for diabetics. However it seems to do much more than just treating diabetics and all of it is good, very good news!

Let me give you the rundown…

[From the US National cancer institute]

“In 1957, the first results from a clinical trial of the diabetes drug metformin in patients were published. Yet, it would take nearly 40 years for the drug to be approved in the United States as a treatment for type 2 diabetes.

Now researchers want to know whether this decades-old drug may have additional uses in another disease—cancer. Based on findings from a number of large epidemiologic studies and extensive laboratory research, metformin is being tested in clinical trials not only as a treatment for cancer, but as a way to prevent it in people at increased risk, including cancer survivors who have a higher risk of a second primary cancer.

Numerous early-stage clinical trials are currently under way to investigate metformin’s potential to prevent an array of cancers, including colorectalprostateendometrial, and breast cancer. Several of these trials are being funded by NCI’s Consortia for Early Phase Prevention Trials. And NCI is collaborating with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to study participants from the landmark clinical trial, the Diabetes Prevention Program (DPP), to investigate metformin’s impact on cancer incidence.

Some of the early-phase prevention trials of metformin are enrolling participants who are at increased risk for cancer and who are obese, have elevated glucose or insulin levels, or have other conditions that put them at risk for diabetes.

“With the obesity epidemic, these studies are applicable to a substantial portion of the U.S. population and, increasingly, of the world population,” said Brandy Heckman-Stoddard, PhD, MPH, of NCI’s Division of Cancer Prevention.

Expanding the Data Pool

Much of the human data on metformin and cancer has come from epidemiologic studies of people with diabetes. In many, though not all, of these studies, people with diabetes who were assigned to take metformin had a lower incidence of cancer than those taking other diabetes drugs.

Completed in 2002, the original DPP enrolled more than 3,200 people at increased risk of developing diabetes and randomly assigned them to one of three groups: one group received metformin, one took part in an intensive diet and physical activity program, and one received a placebo. Participants in the metformin arm had a substantially lower risk of developing diabetes than the general population; participants in the exercise and diet regimen fared even better.

With NCI’s involvement, the program’s extension, called the DPP Outcomes Study, will allow investigators to document cancer incidence and death among study participants. Those observations should provide some of the strongest data available to date on metformin’s anticancer effects in people without diabetes, explained Dr. Heckman-Stoddard. The first data on cancer outcomes in study participants, which will be based on 15 years of follow-up, should be available in 2014.

“Once we have that data, there are a host of other questions we can ask,” she said. For example, Dr. Heckman-Stoddard and her colleagues plan to study metformin’s impact on certain blood biomarkers that studies have suggested are associated with cancer risk. They will also study the drug’s mechanism of action—that is, how metformin may work to prevent changes in cells that can lead to cancer.

For Prevention, Small Biomarker-Driven Trials

The smaller prevention trials being conducted are very different from the DPP Outcomes Study. These trials are not designed to determine whether metformin prevents cancer. Prevention trials must generally have a large number of participants and span many years to show whether a drug or some other intervention reduces the risk of cancer.

Instead, these short, 3- to 6-month trials are investigating whether the drug has an effect on specific proteins and/or signaling pathways that have been implicated in cancer development and that laboratory studies have shown are affected by metformin.

At the University of California, Irvine Chao Family Comprehensive Cancer Center, for example, Jason Zell, DO, MPH, is leading an early-phase clinical trial that is testing metformin’s effect on the mTOR signaling pathway in obese people who have previously had precancerous growths removed from their colons.

Numerous studies have implicated the mTOR pathway as an integral hub in cancer development and progression, and laboratory studies have consistently shown that metformin can blunt mTOR signaling.

“The key point of the trial is to get at the mechanisms of action … to see if metformin is behaving in the expected manner” based on the lab findings, Dr. Zell explained.

Numerous early-stage clinical trials are currently under way to investigate metformin’s potential to prevent an array of cancers, including colorectal, prostate, endometrial, and breast cancer.

Dr. Zell and his colleagues chose to study obese patients “because of the interesting side-effect profile of metformin, which can include weight loss,” meaning it may not be suitable for underweight, nondiabetic individuals, he continued.

If this first trial shows that metformin is having the expected effects on mTOR signaling, the next trial would be similar but would measure a clinical outcome, such as whether metformin decreases the number of colorectal polyps that return.

phase II trial at the University of California, San Diego Moores Cancer Center is testing metformin’s effects on a host of biomarkers in postmenopausal breast cancer survivors who are obese.

Funded by NCI’s Transdisciplinary Research on Energetics and Cancer (TREC) program, the trial, called Reach for HealthExit Disclaimer, will involve treatment with metformin alone and in combination with an exercise program. The study will examine the effect of 6 months of metformin treatment, with or without exercise, on a host of biomarkers associated with cancer risk. The change in biomarker measurements before and after treatment will be compiled into a score that predicts the risk of dying from breast cancer.

This is all part of the trial’s novel “biomarker bridge” design, the lead investigator, Ruth Patterson, PhD, explained. The biomarkers and the risk score are being derived from an analysis of tissue samples collected as part of an NCI-supported phase III trial called the Women’s Healthy Eating and Living (WHEL) study. This study found that a diet low in fat and high in fruits and vegetables did not reduce the risk of cancer returning in survivors of early-stage breast cancer compared with survivors who maintained their normal diet. Researchers have continued to follow the health of WHEL participants to document their health outcomes, including death from breast cancer.

“The WHEL trial is over, and we have a freezer full of blood samples, and we know participants’ breast cancer recurrences, mortality, and other outcomes,” Dr. Patterson said. “So we’re hooking together a short-term trial with a long-term cohort study by means of blood biomarkers.”

The Dose Is the Question

Most of the cancer clinical trials of metformin use the same doses typically used to treat diabetes. That makes sense, because all of the epidemiologic data suggesting a cancer benefit came from studies that used those doses, said Michael Pollak, MD, of McGill University in Montreal, who has extensively studied metformin and its anticancer potential.

“We already know that those doses are safe, so why not study them?” Dr. Pollak continued. “But then you have to realize that virtually all of the lab studies [of metformin] have been done using drug concentrations that are as much as 100-fold higher than those found in the serum of diabetic patients. So the lab studies do not directly justify the clinical trials that are using conventional antidiabetic doses.”

With the obesity epidemic, these studies are applicable to a substantial portion of the U.S. population and, increasingly, of the world population.

—Dr. Brandy Heckman-Stoddard

Although laboratory studies suggest that larger doses of metformin “deserve study” for cancer treatment, Dr. Pollak noted that “for cancer prevention, we can only consider the hypothesis that the antidiabetic dose, or even lower doses, will be clinically useful.”

Dr. Zell agreed. “In the realm of cancer prevention, where side effects are less acceptable than they are in the realm of cancer treatment, the conventional dose for treating diabetes or something close to it may be the limit.

“I don’t imagine that prevention researchers will be looking to use [significantly larger] doses of metformin,” he continued. “In a healthy population, even a low risk of side effects could be extraordinary when applied to a larger population…. That’s why trials like ours are important. At the end of this 12-week intervention, we’ll have a good idea of whether the standard dose of metformin can affect cancer signaling pathways.”

Early Days

It’s still far too early to tell whether there is any future for metformin as a means of preventing or treating cancer, several researchers said.

Despite the very strong epidemiological evidence, there’s a chance that, even if metformin has some ability to prevent cancer, its efficacy may be limited to just several cancer types, Dr. Pollak noted. For example, metformin is not absorbed very well by the body and is absorbed differently by different tissues, he explained, which could limit how effective it might be against particular cancers.

Although the drug in its current form has certain limitations, some investigators are working on developing more potent derivatives of metformin. At the 2012 San Antonio Breast Cancer Symposium, for example, Italian and U.S. researchers reported that several metformin derivatives they had developed potently blocked the growth of breast cancer cells in the laboratory, including cell lines of triple-negative breast cancer, and caused the cells to die.

To be used for cancer prevention, any metformin derivative would have to be safe, with few side effects, Dr. Heckman-Stoddard stressed. As for the original metformin formulation, she added, current trials should help to map the way forward for its use in prevention.

“It’s important that we identify the right populations in which this is most likely to be an effective agent,” said Dr. Heckman-Stoddard. “We need to look at the evidence from all of these early-phase trials as a whole,” she continued, including examining the population groups exhibiting the strongest suggestions of efficacy “so we can design efficient phase III trials.”

Examples of Clinical Trials Testing Metformin for Cancer Prevention

Trial Phase Measured Endpoints Sponsor
Exercise and Metformin in Colorectal Cancer Survivors II Insulin levels and other biomarkers Dana-Farber Cancer Institute
An Endometrial Cancer Chemoprevention Study of Metformin [and Lifestyle Intervention] III Biomarkers in the endometrium and insulin levels University of Texas MD Anderson Cancer Center
Metformin as a Chemoprevention Agent in Non-Small Cell Lung Cancer II Progression of potentially precancerous bronchial lesions (secondary endpoint) in patients who have undergone surgery for lung cancer Mayo Clinic
Prostate Cancer Active Surveillance Metformin Trial II Progression of prostate cancer in men undergoing active surveillance for low-risk disease University Health Network, Toronto
Metformin Hydrochloride as Chemoprevention in Patients with Barrett Esophagus II Changes in the levels of the signaling pathway protein pS6K1, thought to play important role in progression to esophageal cancer Mayo Clinic”

 

The bottom line is that Metformin has already proven to be a powerful tool against some of the most common cancers.

Here is a article by Medscape on whether everyone should be taking Metformin due to it’s incredible benefits: http://www.medscape.com/viewarticle/835676

 

WANT A HOLISTIC TRANSFORMATION SYSTEM FULLY CUSTOMIZED?  The program I am following for the past 6 years (age 46 to 52), available now fully customised on all levels. before-and-after-dec2016Every little secret, every hard-earned practical fact, every scientific study that actually support the (very) few supplements between all the thousand ridiculous advertisement claims have been filtered en incorporated into one system that MAKES A DIFFERENCE click here: 

https://gertlouw.com/my-transformation-secrets/

 

Metformin has been proven to be very safe even for non-diabetics. But since it is a prescription drug you will have to twist your doctor’s finger to get a prescription. Ask him to look at the anti-cancer and weight-loss properties of Metformin…this might change his mind.

So here you have it – 5 powerfull tools in your arsenal for good health, anti pain and anti cancer. As the Vulcan say “Life long and prosper!”

Happy Training

Gert Louw

Gert Louw video cover


This is where a LOT of dedicated people get derailed completely! They get sick or injured and well, that is where their road to transforming the body stops…dead in it’s tracks. Until that point they are so motivated and charged up and then that happens…and the de-motivation is just too much. They just never get it off the ground again afterwards.

Right now, I am down from gym with kidney infection and this will keep me out of gym for close to 7 days. But after the 7 days off, I’ll be back doing one week light work and then all back to normal.

Not ONE of us are spared sickness or injuries. Now, injuries we can manage better especially with applying more wisdom as we get older (warming-up, stretching and simply avoiding high risk exercises for injury). But sickness is difficult to prevent. Sure we can apply the basics (anti-oxidants, multi-vit, CQ10 and ALA) and wash our hands regularly with anti-bacterial soap/spray, but even with that, chances are we will still get flu in the winter and still get the odd infection.

It is not a matter of preventing sickness and injuries but a matter of accepting that they form part of the training/body transformation environment as a given. You WILL get sick and you WILL get injured. But that must never (!) derail your efforts. Accept that it will push you back one to two weeks. Do not allow yourself to get negative about it, it is PART of the whole process and those with a winning mindset accepts that!

Now, what is even more important is that after a week of sickness, be careful to go in full force back to gym. Your body is still weak and in a process of recovery. Your immune system not nearly back to normal. Pushing yourself to the limits the first week back can and most probably will result in a recurrence of the sickness even to a worse degree putting you out gym for 3 weeks or more. That first week back after being sick make sure you do not do more than 50% your normal capacity. Go through all the motions and exercises but keep the exertion levels low.

Then the 2nd week back in training you will find you feel yourself again. That is where you start pushing the limits again.

A KEY ingredient of the winning mindset is to force yourself to stick 100% to your diet while sick or injured. Doing this will go great lengths to keep the motivation levels high! This is NOT the time to binge or eat what you want. This is the CRITICAL time to feed the body correctly. Sometimes I experienced when going back after a week sick I actually am in better shape than before, simply because of the control I had with my diet and my body that actually had a well deserved break!

Now, my timing for my kidney infection is real bad because 21st May I got a photoshoot coming up. But that is where all your hard work you have put in over the previous months and years will show the dividends…

Wish you all good health and injury free training!

Gert Louw

http://www.gertlouw.com

Gert Louw INJURY


This is probably the single most confusing area for anyone want to venture the road of fitness/bodybuilding or just to transform their body for a “wow” look.

 

The first question is, “Do I need to take supplements at all”?

Now those of you that have followed me for a while know that I am very (!) outspoken against supplements. My photos have been stolen and abused with fake stories by supplement companies more than 80 times now (those are the one’s I actually busted, let alone the one’s I don’t know about).

So the bottom line is EVERY advert you read about how great this or that product is, is hugely inflated and chances are very high the photos produced as proof are stolen and the stories as proof are fake. There is NO (!) magic pill out there. Not even anabolic steroids can do what some of these supplement companies claim, ie: “complete body transformations in 14 days or 3 weeks”!

So lesson one – NEVER read supplements advertisements. It has 90% lies and 10% truth. Very few real advances have been made in the last decade or so about supplements for bodybuilding. I am not talking about hollow claims, but I am talking about real scientific independent studies and proof.

Those that is going to believe me and listen to what I say will save THOUSANDS of dollars!

Bodybuilding and fat loss supplements contribute a miniscule 2.5% to your overall results. Thus, you CANNOT waste your money on any supplement that is not highly effective and focused.

Now all that being said, truth is, there are a core group of supplements for both your general health (very important for those putting their body under strain due to heavy training and dieting) and for creating and environment for muscle-building and fatloss and increase your repair ability of your body.

Anything outside these groups of supplements you need to question and REALLY do your homework before parting with your hard-earned money.

Click here to view video “How to choose the RIGHT supplements for muscle building and fat loss”

 

Regarding BRANDS

Now generally anyone knowing me, knows that I am steering clear here because I do not like promoting brands and shooting others down. BUT, I had so many people ask me about safer brand options. So here is my opinion:

Experience and knowledge leads here. Let me explain. NO supplement out there, with little to no scientific studies to back it up, can make any significant difference no matter what the marketing or claims are.
The are MANY, MANY scam supplements out there that are totally worthless and it cost and arm and leg.
So the first rule is, it MUST be backed up by various independent scientific studies and control groups. This immediately cancel 95% of supplements!
The rest well, there are various degrees of success. Even if it is backed up by solid studies, if the effect is minimal, one is wasting your time and money.
The supplement must have a significant effect to be even considered.
Now, filtering through everything with the above rules and the supps I suggest are the ones that can and will make an ever so slight but important difference (see section below). The only one outside of this group is creatine…for about 90% of people it can have solid advantages (even to the degree of the most potent supp this side of anabolic steroids)…but that should only be used while on a building phase and not cutting phases. Just a note on creatine – anyone with kidney issues should steer clear…creatine is placing some strain (albeit moderate) on the kidneys. So drink LOTS of water while on it.
When buying the “approved” supplements…stick only to highly reputable BIG brands, EAS, On Nutrition, Animal and Muscletech.
That does not mean all the supplements these companies sell, is working…they sell whatever the public has been brainwashed to buy! So tread carefully!
Which brand I use? A local, South African brand – HMT, but you will only have access to it if you are in South Africa and the range is designed specifically for competing athletes.

 

INTERESTED IN MY ONLINE COACHING SYSTEMS – TRANSFORMING YOU BODY? CLICK HERE advanced coaching and body transformation systems

 

First, let’s look at GENERAL HEALTH supplements (supported by science and real world trials)

 

CQ10 (Co-Enzyme Q10) – the number ONE potent health supplement out there. [150mg – 300mg daily]

“Coenzymes are substances that help the activities of enzymes. Evidence shows that Coenzyme Q10 plays a very important role in the production of energy throughout the body. It also has been found to have powerful antioxidant effects, destroying free radicals in the body.

Improved energy production is of particular importance to athletes and bodybuilders.

Coenzyme Q10 helps the body convert food into energy in the form of ATP. Nearly every cell in the body contains at least some Coenzyme Q10, with mitochondria, the energy powerhouses of cells, containing the most. The heart and liver, due to their high content of mitochondria, contain the most Coenzyme Q10 out of any organs in the body.

In a placebo-controlled study, Coenzyme Q10 supplementation was shown to help people with congestive heart failure. People with congestive heart failure may not see any results for a few months, but should not quit taking it immediately without consulting a doctor. People with angina have been able to exercise for longer periods of time and with more energy when supplementing with Coenzyme Q10. It has also been shown to lower blood pressure and improve the pumping function of the heart.

Coenzyme Q10 may even help facilitate weight loss due to its stimulating effects on the body’s metabolism. Evidence suggests that Coenzyme Q10 can help in a number of ailments and diseases including: diabetes, angina, give support with chemotherapy, male infertility, mitral valve prolapse, give support with HIV, gingivitis, and congestive heart failure.  The assimilation of Coenzyme Q10 may be better if taken with a fatty substance such as oil, peanut butter, olive oil, etc.”

CQ10 has also shown to have highly effective pain treatment properties, especially for migraine sufferers.

 

ALA(Alpha lipoic Acid) [200mg – 400mg daily]

“In addition to the anti-oxidant effects that ALA produces the list below shows why it is such an important supplement. The list of benefits includes:

  • Improving of physique
  • Combats free radicals
  • Protects our genetic material
  • Slows aging
  • Protects against heart disease
  • Protects against cancer
  • Improves skin and helps erase wrinkles
  • Regulates blood sugar in diabetics
  • Protects the liver
  • May be used as a treatment for Stroke

If Alpha-Lipoic Acid were just another antioxidant, then its value would be far less. After all, there are dozens of ingredients on the market that have powerful antioxidant functions. However, the unique qualities possessed by Alpha-Lipoic Acid, functioning as both a water- and fat-soluble antioxidant make it an intriguing ingredient and a supplement worthy of serious consideration.”

 

Omega 3+6 [2g to 6g per day]

“Omega-3 fats are essential fats your body needs for brain development that may also help limit your risk for heart disease. Good sources include flaxseeds, walnuts, salmon, herring, tuna, mackerel, sardines and other fatty fish. The Academy of Nutrition and Dietetics recommends getting at least 500 milligrams per day of EPA and DHA, the main omega-3 fats found in seafood.

Getting plenty of omega-3 fats in your diet may help increase your feelings of fullness, making it easier to lose weight and keep it off, according to a study published in Appetite in November 2008. A review article published in Nutrients in 2010 noted that omega-3 fats may help with weight loss by reducing appetite and increasing fat burning, especially when combined with a reduced-calorie diet and exercise.

Omega-6 fats are essential as well, but most people get more of these than they need in their diets. A high ratio of omega-6 to omega-3 fats, such as that found in the typical American diet, may increase inflammation and your risk of cancer, heart disease and arthritis. If you’re trying to lose weight, it may be best to limit your omega-6 consumption, which can cause you to retain water. Aim for a 3-1 ratio of omega-6 to omega-3 fats, recommends Unity Health System. These fats should make up between 5 and 10 percent of your total calories for the day. Some of the main sources of omega-6 fats include soybean oil, safflower oil and corn oil.”

Consumption of Omega 3 + 6 will actually help you to lose fat!

 

Potent Multi Vitamin [as directed on container]

When the body is under strain due to serious training and dieting, then you need larger amounts of trace minerals/vitamins to ensure that the body stays healthy. Some doctors lately actually support the notion that one does not need a multi-vitamin at all. However, I oppose this notion, especially when it comes to a body under strain. Potent type multivitamins contains higher dosages of all vit/min combinations than those used by non-active people. Just a note here: Never use anti-oxidants or Multi Vit in near to the time you train. It has been shown by recent science studies that this limits your body’s ability to lose fat. Use it as far removed from your training session. Good examples: Optimen, Optiwomen, Animal Pak, Nano Pack by Nuskin, etc…

 

Now, about supplements that can make a real difference in the bodybuilding/fat-loss environment:

BCAA – branched chained amino acids [use as directed on container – buy shake and not pill form]

BCAA shake while training has been proven scientifically to “force” your body’s energy requirements to come from the fat reserves and not the muscles. You NEVER want energy to come from the muscles, when that happens, you enter a catabolic state = smaller muscles! BCAA goes a long way to help stop this process and encourage energy to come from fat reserves. It is a critical component when you train heavy and intense and is best use while training in shake form.

L-Glutamine [5g before and 5g after training]

L-Glutamine has been proven through various science studies to be a miracle bodybuilding supplement.

  • Glutamine has been linked to protein synthesis. It prevents your muscle from being catabolic (eaten up) in order to provide Glutamine for other cells in the body.
  • Glutamine helps maintain cell volume and hydration, speeding up wound and burn healing and recovery.
  • Glutamine benefits you by replenishing declining Glutamine levels during intense workouts.
  • Research has shown Glutamine can help you produce growth hormone levels. A study has shown 2 grams of L-Glutamine increased growth hormones by over 400%.
  • Glutamine may serve to boost your immune system. For bodybuilders, this is important since heavy workouts tend to greatly deplete Glutamine levels. (Glutamine is a primary energy source for your immune system.)
  • Glutamine is one of the most important nutrients for your intestines. It has the ability to ‘repair a leaky gut’ by maintaining the structural integrity of the bowels.
  • Bet you didn’t know this: It can even cure ulcers! Studies have found that 1.6 grams of Glutamine a day had a 92% cure rate in 4 weeks.

Researchers are suggesting that Glutamine is the most important amino acid to the bodybuilder. It provides a component in muscle metabolism and cellular support not shared by any other single amino acid, making the benefits of L-Glutamine supplementation a realistic venture.

Glutamine has also various benefits for hiv+ people.

Whey protein [40g immediately after training]

Immediately after training you need to spike the insulin. This is to create a potent environment for growth. Insulin is the most powerful muscle-building hormone in the body. To do this, one consume 40g of whey protein (without added carbs or fats) and eat a banana or apple. This is a key aspect for anyone serious about building muscle and loosing fat. This will also feed the muscles very much-needed nutrients.

 

Creatine – optional [use as directed on container and pre load if necessary]

Creatine will work for some and for some not. For those that it does work, it can be the most potent muscle-building supplement this side of anabolic steroids. So it might be worthwhile to test out. Just be carefull, creatine places strain on kidneys and only use if you have healthy kidneys. Creatine must always be use together with grape juice or Vitargo for best absorption.

 

Ok, now you have some guidance about what to choose between all these 1000’s of supplements.

 

But just some food for thought about your plans to transform that body this year…

Everyone experience failure along the adventure of transforming their body, but those that get to the goal post are those that got up EVERY time after they failed on diet or training for a day or a week and kept going…THAT is the single biggest and most important ingredient for EVERYONE who reach the goal post of a “wow” transformation. Like a well-known slogan says: “JUST DO IT.” Don’t think about it…DO IT! The more you think about it, the more reasons you will find not too. Because it is an effort. It is not easy and it will take a lot of sweat and pain. But the adventure is incredible and will change your life forever. The return on your investment will be unbelievable! Reach for the stars, nothing less…

But to make it worthwhile, change everything…inside and out. become the best person you can be, with integrity, kindness and compassion, otherwise it is a hollow aim that will let you just become a more well-known jerk instead of a guy people look up to and admire for more than just their body. A role model that can change the world!

Here are 3 incredible transformation photos – look at them and burn them in your mind…GET TO THAT GOAL POST!

f0bb03272e74e54f7dcd59e237d74e6d maxresdefault stunning_body_transformations_640_02

Click here to watch video “HOW TO TRANSFORM TO A “WOW” PHYSIQUE”.

 

It can be done…but YOU will have to do it and MAKE IT HAPPEN.

For those that want complete customised transformation systems and diets to get you to the goal post, follow this link for some of the most comprehensive systems in the business: https://gertlouw.com/contact-me/

And lastly, here is my transformation pic (age 50 on the right):

 

gert b&A 12May2016 small

Make 2016 the year you become the best you can be…from the inside and outside!

Wish you all a great day.

Gert Louw


Click here to watch the video “Super supplement for pain relief revealed”

 

I will be making a few videos about a group of “super” supplements that stands out head and shoulders above the rest and which can make a massive difference in many people’s lives.

A little background: 10 years ago I was told by some doctors I have but a few years to live. I refused to accept that and started on my own journey of fitness and supplementation in an effort to built up and repair my broken body. As many know, this is now 10 years later and I look the best I’ve ever did in my life. In this article I want to share some of my knowledge.

When I was told my fate 10 years ago I did not had time to waste on mediocre supplement or stuff that make just marginal differences. If I add it to my critical list it need to make a huge difference, full stop.

One of these super supplements that made my critical list is Co-Enzyme Q10.

Apart from it’s legion of amazing benefits, scientific research studies are finally proving that it has a rather high degree of effectivity for fighting certain pains, particular migraines and Fibromyalgia. Some doctors even started to prescribe CQ10 to their migraine patients and report amazing results. Fibromyalgia sufferers, seems to be able to live a quality life again with the help of CQ10. They do not report a complete reduction of pain but enough to give them hope for a quality life.

Hiv + people and cancer sufferers has particularly low levels of CQ10 and for them it is an absolutely MUST TAKE supplement for such people.

 

What is it?

Coenzyme Q10 is a mitochondrial energizer that has shown remarkable effects against common heart ailments and neurological disorders. In just the past year, scientists have uncovered specific mechanisms indicating that CoQ10 may have a role in fighting certain cancers. Most surprising, however, are new studies that show how CoQ10 guards against a wide array of common age-related disorders. CoQ10 is naturally present in small amounts in a wide variety of foods, but levels are particularly high in organ meats such as heartliver, and kidney, as well as beef, soy oil, sardines, mackerel, and peanuts.

 

Some of the amazing benefits

(Extract from http://www.lef.org)

Preventing the Onset of Migraine

Migraine headaches are a debilitating, all-too-common affliction. Because mitochondrial dysfunction may play a role in migraines by limiting oxygen metabolism, researchers recently explored the use of CoQ10 in preventing these headaches. Published in the February 2005 issue of Neurology, the research describes a placebo-controlled trial of 42 patients in Switzerland.2

Patients who had suffered migraines for a year or more, with two to eight attacks per month, were randomly assigned to receive either 100 mg of CoQ10 or placebo, three times daily. At the end of the three-month trial, the CoQ10-treated group had lower attack frequency and fewer headache days and days with nausea than did the placebo group. The mean number of monthly migraine attacks dropped from 4.4 to 3.2 in the CoQ10 group, compared to a negligible decrease from 4.4 to 4.3 in the placebo group.2

In this study, supplemental CoQ10 reduced migraine frequency by 27%

 

Guarding the Brain After Cardiac Arrest

People who survive cardiac arrest often suffer irreversible brain damage as a result of the disruption of oxygen to the brain. European researchers recently investigated whether combining CoQ10 with mild hypothermia—a technique proven to reduce neuronal damage and increase survival—might enhance the effects of that treatment.1

Forty-nine patients who had suffered cardiac arrest and then received cardiopulmonary resuscitation were randomly selected to receive hypothermia (reduction of body temperature) treatment plus CoQ10 or hypothermia plus placebo. The hypothermia treatment involved the patients being placed on a body-surface-cooling mattress.

The patients were then administered either liquid CoQ10 (250 mg followed by 150 mg three times daily for five days) or a placebo through a nasogastric tube. The remarkable findings showed that three-month survival in the CoQ10 group was 68%, compared to only 29% in the placebo group. Coenzyme Q10 thus helped reduce the death rate from cardiac arrest by an astounding 57%. The researchers also found that 36% of patients in the CoQ10 group had a good neurological outcome at three months, versus only 20% in the placebo group.1

 

Slowing Early Macular Degeneration

Age-related macular degeneration is the most common cause of vision loss in people over 60.3 With the deterioration of the macula (a tiny cluster of highly specialized cells in the retina) central vision progressively begins to blur. As the disease worsens, central vision loss may increase until it becomes impossible to perform tasks that require detailed vision, such as driving and reading.

In recent years, researchers have focused on how oxidative damage affects age-related macular degeneration. The eye, one of the body’s most metabolically active organs, not only generates an enormous amount of free radicals through normal function, but also incurs additional oxidative damage from ultraviolet radiation and air pollution. In recent trials, the use of antioxidants has been shown to counter age-related macular degeneration. For example, in an 11-center, double-blind clinical trial conducted by the National Eye Institute (a division of the National Institutes of Health), a combination of antioxidants plus zinc slowed macular degeneration progression in people with intermediate or advanced disease by about 25%.4

Hungarian scientists are now exploring a metabolic rather than an antioxidant approach to managing macular degeneration. Citing findings that mitochondrial dysfunction might also play a role in the development of the disease, the researchers designed a clinical trial to evaluate intervention in early age-related macular degeneration with a combination of compounds—including CoQ10—that have demonstrated the ability to improve mitochondrial metabolism. The researchers reported results of their double-blind, placebo-controlled trial last year in the journal Opthalmologica.5 More than 100 patients with early age-related macular degeneration were randomly assigned to receive either two capsules per day containing 200 mg of acetyl-L-carnitine, 780 mg of omega-3 fatty acids, and 20 mg of CoQ10, or capsules containing an equal quantity of soy oil.

At the end of the 12-month treatment period, the researchers found statistically significant improvement in the treatment group as measured by all four parameters of visual function studied. In addition, only one of the 48 patients (2%) in the treatment group showed clinically significant worsening in visual field mean defect (blind spots in the visual field), the primary study endpoint, compared to 9 of 53 patients (17%) in the placebo group. The decrease in drusen—tiny yellow retinal deposits associated with macular degeneration—of the treated eyes was also statistically significant compared to placebo when either the most-affected eyes or the less-affected eyes were considered. In the less-affected eyes, the drusen-covered area decreased by 23% in the treated group, but increased by 13% in the placebo group. These findings suggest that intervention with an appropriate combination of nutrients that affect mitochondrial lipid metabolism may stabilize and even improve visual functions in early age-related macular degeneration.5

 

New Applications in Fighting Cancer

Research on CoQ10 and cancer has focused on two lines of inquiry: CoQ10’s ability to improve immune response and its ability to decrease the cardiotoxicity caused by a common class of anti-cancer chemotherapeutic agents.

 Patients with cancer often exhibit low levels of CoQ10

Based on these findings, Danish researchers investigated CoQ10’s effects alone and in combination with other nutrients as an adjunctive therapy for breast cancer.

In one case report, the researchers describe three breast cancer patients with metastasized cancer. The women underwent conventional cancer treatment and supplemented with a daily dose of 390 mg of CoQ10. All three women demonstrated tumor regression and decreased incidence of metastasis.9

In another study, the same research team investigated 32 high-risk breast cancer patients whose malignancy had spread to the lymph nodes.10 In addition to conventional therapeutic interventions, this group of patients received a daily combination of nutrients (vitamin C: 2850 mg; vitamin E: 2500 IU; beta-carotene: 32.5 IU; selenium: 387 mcg; and secondary vitamins and minerals), essential fatty acids (1.2 grams of gamma linolenic acid and 3.5 grams of omega-3 fatty acids), and 90 mg of CoQ10. At the end of the 18-month trial, six patients showed apparent partial remission, none of the patients showed signs of additional metastases, and their quality of life improved. None of the patients died during the study period, though four deaths were expected based on the patients’ disease stage. In one of the six patients with partial remission, the dose of CoQ10 in the nutritional protocol was increased to 390 mg. After two months, that patient’s tumor had disappeared completely, as confirmed by a mammogram.10

While chemotherapy drugs can be highly effective, their use can also be limited by toxic side effects. This has been noted in the case of anthracyclines, a class of drugs widely used in cancer chemotherapy. These drugs have demonstrated efficacy in the treatment of leukemia, lymphomas, and solid malignancies, and are often used to treat breast cancer, with higher doses yielding greater clinical responses. These higher doses of anthracyclines, however, can produce toxic effects on heart tissue, possibly leading to cardiomyopathy and heart failure that are not responsive to conventional pharmacological interventions.11 In fact, anthracyclines selectively damage mitochondria in the heart, but not in other organs.11 Since coenzyme Q10 supports both heart tissue and mitochondria, researchers conducted human trials to determine whether CoQ10 might prevent cardiotoxicity during the administration of anthracyclines.12

Two recent review articles addressed CoQ10’s potential as an adjunctive therapy during chemotherapy with anthracyclines. Writing in the Journal of Clinical Oncology, researchers summarized five reviewed studies in which CoQ10 was given along with anthracyclines.12 They report that in three of the studies that measured heart rhythm, patients who received CoQ10 showed favorable changes suggesting that CoQ10 might have a stabilizing effect on the heart. They also note that supplementation did not interfere with anthracycline treatment, and that no adverse effects were reported in any of the trials. The authors concluded that although coenzyme Q10 demonstrates potential for reducing cardiotoxicity, larger and more rigorous investigations are needed.

In 1961, scientists saw that people with cancer had little CoQ10 in their blood. They found low CoQ10 blood levels in people with myeloma, lymphoma, and cancers of the breastlungprostate,pancreascolonkidney, and head and neck. Some research has suggested that CoQ10 helps the immune system and may be useful as a secondary treatment for cancer.

  • CoQ10 may keep the antitumor drug doxorubicinfrom hurting the heart.
  • Three studies examined the use of CoQ10 along with conventional treatment for cancer. The three studies contained a total of 41 women with breast cancer. In each study, the women improved.

Slowing Neurodegenerative Disease Progression

Many investigators have conducted preclinical studies examining how oxidative stress and impaired mitochondrial function may contribute to neuronal cell death, a characteristic of Parkinson’s, Alzheimer’s, and other neurodegenerative diseases.13-17 For example, a recent journal article in Toxicology and Applied Pharmacology reported on the effects of the herbicide paraquat on neuronal cell death in the laboratory.17 The researchers found that this toxic chemical damaged mitochondria and increased free radical production, eventually resulting in the death of neuronal cells. Pretreatment of the cell cultures with CoQ10, however, inhibited both mitochondrial dysfunction and free radical generation.17 The researchers postulated that coenzyme Q10 may prove useful in preventing and treating neurodegenerative conditions related to environmental toxins.

While published research on the use of CoQ10 in slowing the progression of Alzheimer’s disease has been limited to preclinical studies, investigations of CoQ10 and Parkinson’s disease have moved into clinical trials, including randomized controlled studies. This work has been led by Clifford Shults, MD, professor of neurosciences at the University of California at San Diego School of Medicine. In Parkinson’s disease, brain cells that produce the neurotransmitter dopamine progressively die. Research in animals has shown that CoQ10 can protect the substantia nigra, the area of the brain where these cells reside. Studies by Dr. Shults and others have shown that mitochondrial dysfunction and diminished mitochondrial CoQ10 levels frequently occur in Parkinson’s sufferers.18

With funding from the National Institute of Neurological Disorders (a division of the National Institutes of Health), Dr. Shults and his colleagues undertook the first double-blind, placebo-controlled, multicenter clinical trial of CoQ10 in patients with early untreated Parkinson’s disease. In this phase II, dose-finding study, 80 patients were randomly assigned to receive one of three different CoQ10 doses (300 mg/day, 600 mg/day, or 1200 mg/day) with vitamin E, or a placebo containing vitamin E alone. The patients were followed for 16 months or until the participants required levodopa, a standard drug treatment for managing disease symptoms.19

The results, reported in the Archives of Neurology, showed that patients who received the largest dose of CoQ10 (1200 mg/day) had 44% less decline in mental function, movement, and ability to carry out activities of daily living than those who received the placebo.19 Patients who received CoQ10 doses of 300 mg/day and 600 mg/day also showed some slowing in decline compared to the placebo group, but not as much as those who took the highest dose. The authors concluded that CoQ10 was safe and well tolerated at doses up to 1200 mg/day.

Most recently, Dr. Shults and his team conducted an open label trial in which 17 patients were given an escalating dose of CoQ10 (1200 mg/day, 1800 mg/day, 2400 mg/day, and 3000 mg/day) combined with a stable dose of 1200 IU/day of vitamin E over a two-month period.20 They found that CoQ10 was well tolerated at high doses, but plasma levels of CoQ10 did not continue to rise when the dose was increased from 2400 to 3000 mg/day. There was no significant change in motor abilities in these Parkinson’s disease patients, some of whom were concurrently taking medications for the disease. Based on these findings, the researchers recommended conducting a phase III study to investigate the longer-term effect of high doses on previously untreated patients.

“Our [phase III] study will compare a placebo with 1200 mg/day and 2400 mg/day of CoQ10 and will enroll 200 subjects with early untreated disease in each treatment arm,” Dr. Shults told Life Extension in an exclusive interview. “The study . . . will probably take four years, with the results published a year later,” he added. In addition to that study, the National Institute of Neurological Disorders and Stroke is currently investigating the effects of a 2400-mg/day dose of CoQ10 in patients with early, untreated Parkinson’s disease.18

A clinical trial has also been undertaken in patients with Huntington’s disease, a neurodegenerative genetic disorder. This trial, conducted by the Huntington Study Group, randomly assigned 347 patients with Huntington’s disease to receive CoQ10 at 600 mg/day, remacemide hydrochloride at 600 mg/day, a combination of both, or placebo. Over the 30-month trial, the CoQ10 treated patients showed a 13% decrease in overall functional decline and beneficial trends in some secondary measures. However, the difference between the CoQ10 group and the other groups did not reach statistical significance.21

 

Other Potential Applications

In recent months, scientists have uncovered a widening array of applications for coenzyme Q10. According to new studies, CoQ10 may:

Protect against hearing loss. Mitochondrial DNA mutation is one cause of sensorineural hearing loss, a condition that causes changes in the inner ear or nerve pathways and is not correctable through medical interventions.23 In individuals with genetically based sensorineural hearing loss, coenzyme Q10 supplementation prevented further loss of hearing, while the control that did not supplement demonstrated continued deterioration of hearing function.

Improve learning. Supplementation with vitamin E and coenzyme Q10 helped a group of older mice to learn tasks more quickly than mice supplemented with only one of the two antioxidants.24 These findings suggest that coenzyme Q10 and vitamin E act in concert and may together help prevent age-related deficits in cognitive function.

Extend life span. In animals fed a diet enriched with polyunsaturated fatty acids, supplementing with coenzyme Q10 increased life span and protected against DNA alterations. Scientists recently determined that CoQ10 supplementation may confer these benefits by attenuating the decline in naturally occurring antioxidants that commonly accompanies aging.25

Prevent cachexia. The combination of coenzyme Q10 with vitamins B2 (riboflavin) and B3 (niacin) offers promise in preventing the weight loss and muscle wasting associated with cancer. In cancer, mitochondrial energy production is diminished, which may ultimately lead to the fatigue, weight loss, and muscle loss known as cachexia. In rats with experimentally induced breast cancer, supplementation with the energy-modulating nutrients B2, B3, and CoQ10 helped restore mitochondrial energy production, suggesting that this nutrient combination may help prevent cachexia.26

Assist muscle regeneration. Supplementing with coenzyme Q10 and vitamin E supported muscle regeneration in animals with experimentally induced muscle decay. The investigators noted that CoQ10 exerted a greater influence on muscle regeneration than did vitamin E.27

Protect against surgical stress. Supplementing with 300 mg of CoQ10 daily for two weeks prior to heart surgery boosted measures of heart muscle health, investigators recently noted. When heart muscle samples of the supplemented individuals were analyzed following elective surgery, this tissue exhibited improved energy production, decreased oxidative stress, and enhanced recovery from oxygen depletion compared to tissue samples from unsupplemented patients.28

Promote male fertility. Coenzyme Q10 supplementation for six months improved asthenozoospermia (reduced sperm motility) in infertile men.29 In an earlier study, administering a CoQ10 analog to men led to significant increases in both sperm count and motility.30 These findings suggest that CoQ10 may help improve defective sperm function, a common and difficult-to-treat cause of male infertility.

Protect against senile plaques. A laboratory study demonstrated CoQ10’s ability to destabilize amyloid beta peptides, a hallmark abnormality of Alzheimer’s disease.31 This suggests a further potential neuroprotective mechanism of coenzyme Q10.

Impede diabetic complications. An animal study has shown that CoQ10 displays potential for preventing complications associated with diabetes.32

Lower triglycerides. The results of an Italian preliminary clinical trial suggest that the combination of CoQ10 and fibrate drugs may benefit individuals with exceedingly high levels of triglycerides who fail to respond to fibrates alone.33

Summary

The latest findings suggest that, along with its heart-protective effects, CoQ10 may slow or improve some degenerative diseases, support cancer remission, counteract the toxic effects of chemotherapy, and decrease the incidence of migraine headaches. Additionally, recent findings indicate that coenzyme Q10 may have applications in promoting fertility, protecting auditory function, supporting longevity, boosting learning capability, sustaining muscle health and much more.

CoQ10 investigations are expanding into new areas, and researchers are now calling for larger, well-designed studies to support intriguing findings from small and observational trials. With CoQ10’s pervasiveness in the body and the many essential functions it performs, scientists will no doubt continue to elucidate this vital nutrient’s many potential applications.

DYNAMIC DUO: COQ10 AND VITAMIN E
In addition to its direct scavenging of free radicals, CoQ10 also helps regenerate vitamin E, another important antioxidant. Vitamin E provides antioxidant protection in fat-soluble environments such as cell membranes.18 When coenzyme Q10 levels in cell membranes are diminished, regeneration of vitamin E is slowed as well.22

Is CoQ10 safe?

Taking 100 mg a day or more of CoQ10 has caused mild insomnia in some people. And research has detected elevated levels of liver enzymes in people taking doses of 300 mg per day for long periods of time. Liver toxicity has not been reported.

Other reported side effects include rashesnausea, upper abdominal paindizziness, sensitivity to light, irritability, headacheheartburn, andfatigue.

Medicines for high cholesterol (statins) and medicines that lower blood sugar cause a decrease of CoQ10 levels and reduce the effects of CoQ10 supplements. CoQ10 can reduce the body’s response to theblood thinner (anticoagulant) medicine warfarin (Coumadin) and can decrease insulin requirements in people with diabetes.

The U.S. Food and Drug Administration (FDA) does not regulatedietary supplements in the same way it regulates medicines. A dietary supplement can be sold with limited or no research on how well it works or on its safety.

 

This information is not intended to replace the advice of a doctor. http://www.gertlouw.com disclaims any liability for the decisions you make based on this information.

 

References
1. Damian MS, Ellenberg D, Gildemeister R, et al. Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study. Circulation. 2004 Nov 9;110(19):3011-6.2. Sandor PS, Di CL, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology. 2005 Feb 22;64(4):713-5.3. Available at: http://www.nei.nih.gov/health/maculardegen.armd_facts.asp#1. Accessed November 16, 2005.4. Anon. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001 Oct;119(10):1417-36.

5. Feher J, Kovacs B, Kovacs I, et al. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica. 2005 May;219(3):154-66.

6. Folkers K, Osterborg A, Nylander M, Morita M, Mellstedt H. Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. Biochem Biophys Res Commun. 1997 May 19;234(2):296-9.

7. Portakal O, Ozkaya O, Erden IM, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem. 2000 Jun;33(4):279-84.

8. Folkers K, Morita M, McRee J, Jr. The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem Biophys Res Commun. 1993 May 28;193(1):88-92.

9. Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun. 1995 Jul 6;212(1):172-7.

10. Lockwood K, Moesgaard S, Hanioka T, Folkers K. Apparent partial remission of breast cancer in ‘high risk’ patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med. 1994;15 Suppls231-s240.

11. Conklin KA. Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity. Integr Cancer Ther. 2005 Jun;4(2):110-30.

12. Roffe L, Schmidt K, Ernst E. Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review. J Clin Oncol. 2004 Nov 1;22(21):4418-24.

13. Somayajulu M, McCarthy S, Hung M, et al. Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis. 2005 Apr;18(3):618-27.

14. Sohmiya M, Tanaka M, Tak NW, et al. Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson’s disease. J Neurol Sci. 2004 Aug 30;223(2):161-6.

15. Menke T, Gille G, Reber F, et al. Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential. Biofactors. 2003;18(1-4):65-72.

16. Shavali S, Carlson EC, Swinscoe JC, Ebadi M. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells. J Neurosci Res. 2004 May 15;76(4):563-71.

17. McCarthy S, Somayajulu M, Sikorska M, Borowy-Borowski H, Pandey S. Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10. Toxicol Appl Pharmacol. 2004 Nov 15;201(1):21-31.

18. Shults CW. Therapeutic role of coenzyme Q(10) in Parkinson’s disease. Pharmacol Ther. 2005 Jul;107(1):120-30.

19. Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002 Oct;59(10):1541-50.

20. Shults CW, Flint BM, Song D, Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp Neurol. 2004 Aug;188(2):491-4.

21. Anon. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington’s disease. Neurology. 2001 Aug 14;57(3):397-404.

22. Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001 Dec;20(6):591-8.

23. Angeli SI, Liu XZ, Yan D, Balkany T, Telischi F. Coenzyme Q-10 treatment of patients with a 7445A—->G mitochondrial DNA mutation stops the progression of hearing loss. Acta Otolaryngol. 2005 May;125(5):510-2.

24. McDonald SR, Sohal RS, Forster MJ. Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice. Free Radic Biol Med. 2005 Mar 15;38(6):729-36.

25. Bello RI, Gomez-Diaz C, Buron MI, et al. Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp Gerontol. 2005 Aug;40(8-9):694-706.

26. Perumal SS, Shanthi P, Sachdanandam P. Energy-modulating vitamins—a new combinatorial therapy prevents cancer cachexia in rat mammary carcinoma. Br J Nutr. 2005 Jun;93(6):901-9.

27. Otrocka-Domagala I, Rotkiewicz T, Karpinska J, et al. The effect of coenzyme Q10 and vitamin E on the regeneration of skeletal muscles in pigs. Pol J Vet Sci. 2004;7(4):295-303.

28. Rosenfeldt F, Marasco S, Lyon W, et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. J Thorac Cardiovasc Surg. 2005 Jan;129(1):25-32.

29. Balercia G, Mosca F, Mantero F, et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004 Jan;81(1):93-8.

30. Anon. Coenzyme Q10. Altern Med Rev. 1998 Feb;3(1):58-61.

31. Ono K, Hasegawa K, Naiki H, Yamada M. Preformed beta-amyloid fibrils are destabilized by coenzyme Q10 in vitro. Biochem Biophys Res Commun. 2005 Apr 29;330(1):111-6.

32. Al-Thakafy HS, Khoja SM, Al-Marzouki ZM, Zailaie MZ, Al-Marzouki KM. Alterations of erythrocyte free radical defense system, heart tissue lipid peroxidation, and lipid concentration in streptozotocin-induced diabetic rats under coenzyme Q10 supplementation. Saudi Med J. 2004 Dec;25(12):1824-30.

33. Cicero AF, Derosa G, Miconi A, et al. Possible role of ubiquinone in the treatment of massive hypertriglyceridemia resistant to PUFA and fibrates. Biomed Pharmacother. 2005 Jul;59(6):312-7.

 

Happy training everyone!

Gert Louw

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As the years progressed I’ve fine tuned my approach to pre & post workout supplements.

 

The regime I am currently following is highly advisable for anyone who wants to add maximum lean muscle with training. It keeps the body in a anabolic state with energy to spare and quick recovery of exercise induced muscle damage.

It sticks to the core, proven supplements. Keep it simple and stay away from all the fancy stuff with “too good to believe” marketing hype. It is ALWAYS “too good to believe” and ALWAYS utter lies no matter how many “proof” photos they attached (normally stolen) or stories (made-up)!

It is a great tool for the over 40’s or even over 50’s to add muscle. For the younger crowd it means perfect muscle growth environment.

PRE-WORKOUT – 30 to 45 minutes before training

Branched Chain Amino Acids (BCAA’s) 6-8 tablets

The BCAA’s ensure that the energy required during training  is not obtained from your muscles but forces it to obtain it from other places (fat storage, etc..) This protects your muscles from going catabolic during training. A critical supplement in your pre-workout arsenal. In-depth info about BCAA’s can be obtained from: http://www.bodybuilding.com/fun/bcaas-the-many-benefits-of-amino-acids.html

L-Glutamine 5g dissolved in water

When you train your Glutamine reserves of your body will drop very fast (!). When it becomes too low you will feel exhausted and have no stamina/power. When the Glutamine has dropped too low, muscle recovery will be very (!) slow and the body can take up to 6 days to replenish the levels of Glutamine to optimum again. During that time virtually no muscle growth will occur. It is therefore of the absolute importance that you supplement with L-Glutamine before training.

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AGMATINE 1g dissovled in water (together with L-Glutamine)

(In the video I say 1g to 10g Agmatine Sulfate. That is incorrect – the amount is only 1g of Agmatine Sulfate)

The following extract from http://www.bodybuilding.com/fun/jrod17.htm sums it up very nicely as to why specifically agmatine:

  1. Agmatine is a pain fighter. This can be beneficial to the athlete in two ways:
    1. It can potentiate the effects of analgesics used during recuperation from injury.
    2. It has the potential to aid post-workout recovery.
  1. Agmatine enhances insulin production leading to better insulin response. This allows for positive effects in attaining body composition goals. Better insulin response means a harder and leaner more muscular body.
  1. Agmatine acts on various hypothalamic and pituitary peptide hormones such as LH and GH. These will have subsequent effects on other hormones like IGF-1. Control of the hormonal environment of the athlete and you will perform better, look better and feel better.
  1. Agmatine possesses anxiolytic (relieves anxiety) and antidepressant properties offering potential control of cortisol levels in the stressful life of the athlete.
  1. Agmatine modulates nitric oxide (NO) through different ways. It stimulates some types of nitric oxide synthase (NOS) while inhibiting others. This is essential to the proper functioning of the polyamine biosynthetic pathways.
  1. Agmatine acts oncatecholamine (Epinephrine > Norepinephrine > Dopamine) release. These endogenous compounds are part of nearly every action in the body. Most notably for the athlete is the role that this compound would ultimately have in both energy production and aiding anticipation of the stressafforded by competition. However, there are also well-established roles that epinephrine can have on the body that includes:
  1. Agmatine has an antioxidant role. There can be no greater source of free-radical build up than that seen in the day-to-day activity of the athlete. The sheer stress that the body takes on when in you’re an athlete in the trenches (i.e. – the gym, the field, etc…) could ultimately have significant detrimental effects with continued build up. Agmatine can offer protection from the undesired effects that free radicals can have on the body.
  1. For the athlete desiring body composition change, Agmatine has an independent role of insulin and testosterone management on lipid (fat) metabolism.
  2. Agmatine possesses nootropic effects (it acts as a “novel” neurotransmitter). This can offer the athlete a potential mental edge to prepare for various events.
  3. Agmatine can aid in kidney function by stimulating the glomerular filtration rate (GFR). This can bode the bodybuilder well as various nitrogenous waste products are removed through this system.
  4. Agmatine harbors a hypotensive role which could assist the exogenously-enhanced athlete in keeping blood pressure in check.

My training and diet system is available customised for your body and goals. You can signup through this link: https://gertlouw.com/my-transformation-secrets/

 

POST-WORKOUT – IMMEDIATELY after training:

Apple or banana to recover lost energy consumption

L-Glutamine 5g to 8g dissolved in water

Because of the risk of your body’s L-glutamine reserves that dropped during training too low, you IMMEDIATELY must replenish with L-Glutamine after training to ensure your body stays in an anabolic environment.

Remember if you do not do this, it might take up to 6 days of a catabolic environment with no muscle growth despite all your hard work on diet and training.

WHEY protein  – quick absorption 40g mixed in water (together with L-Glutamine)

Your muscles need the right building blocks to recover exercise induced damage and the quicker you feed your body with quick absoption whey protein after training the quicker it can start repairing and building.

Other supplements that might be considered:

Creatine

Creatine might be beneficial for certain individuals. However, for a certain percentage of people creatine have absolutely no effect. Unfortunately I am one of them.

The second reason I am not using it is that it tends to let one look a little bloated, especially when you are trying to cut.

Anti Oxidants (alpha lipoic acid, Co Enzyme Q10, Saw Palmetto)

New research seems to indicate that it might not be such a good idea to take anti-oxidants straight before or after training. It suggests that it must be taken as far removed from training as possible. If taken close to training it seems to be counter productive to a fatloss environment.

Whether you believe that or not, it might be a good idea to consider it. There seems to be rather solid science behind it.

Alpha lipoic acid (about 400mg twice daily) helps regulate your insulin levels which means a better fat-loss environment. Plus it is a very potent anti-oxidant.Co-Enzyme Q10 (about 300mg twice daily) It assist in insulin sensitization. A problem most bodybuilders face is that with repeated insulin spikes as a result of periodically heavy carbohydrate consumption causes the body to become increasingly insulin resistant.

Insulin is probably the most powerful anabolic agents. Spiking insulin levels increase muscle protein synthesis. The Co Enzyme Q10 allows you to drive more nutrients into the     muscles. It is also extremely beneficial for a healthy heart.

Saw Palmetto (about 300mg twice daily). Helps prevent a enlarged prostate…something all guys need to be worried about and prevent!

This regime is proven and will yield great results when accompanied by focused training program and diet structured for lean growth.

Wish you all the success.

Gert Louw


Fibromyalgia and training

Severe muscle pain from the tip of your finger to the tip of your big-toe…struggling to do just about anything and have to live with constant pain 24 hours a day year in year out…this is the people suffering from Fibromyalgia (plus fatigue, stiffness, sleep disturbances, headaches and mood disorders, such as depression or anxiety).

It is so common that I felt it necessary to give some insight into how sufferers can make life bearable.

 

Up to 1 in 50 people struggle with the condition of Fibromyalgia and it is the 2nd most common ailment affecting the musculoskeletal system after osteoarthritis.

 

Between 80%-90% of sufferers are women.

Most men only get it due to a traumatic episode or the likes.

 

Due to how common Fibromyalgia is, I thought it warrants attention in my fitness blog.

 

Medical science struggles to explain the real origin of why people have Fibromyalgia and as such also struggle to treat it effectively. It is however a clear defined condition that can very easily be determined by specific pain pressure points of the muscle system.

Some have it worse than others…some to the degree that they truly cannot get out of bed.

A lot of women get it straight after pregnancy.

Click here to watch the video – “LIFE inspiration – Faith & Hope”

Medication

Effective medication is scarce and doctors struggle to find tools to treat the pain. Yes, you can drink an anti-inflamatory but for how long before the liver or your stomach lining is damaged…not a good solution. Some doctors even reverted to anti-depression drugs which has shown to have a safe long-term pain relief effect. But I don’t know about you…anti-depressents alter brain chemistry and I for one would use that as an absolute last resort and those I know said it had little to no effect.

There just is not an effective long-term pain reliever for Fibromyalgia sufferers.

Some sufferers even went as far as starting to use Marijuana/Dagga. They claim it helps making the pain manageable. Well, I for one must be close to my deathbed before I will start using street drugs or the likes to treat pain.

But sometimes it is easy for us non-sufferers to talk. The pain for the sufferers is very real.

Other routes treating Fibromyalgia

However, there are alternatives to deal with Fibromyalgia and it slots in nicely with making a lifestyle change.

The following “treatment” is safe and can relief more pain then all the conventional and unconventional treatments for Fibromyalgia.

Granted, due to the medical science struggling to determine the exact cause Fibromyalgia can possibly be a diverse type of illness that is not necessarily the same for every person and thus a “standard” treament might not have the same effect for everyone.

However, the following treatment regimen has been followed by some Fibromylagia sufferers with good to great results (although no specific scientific research has been done to verify the success level of these strategies). Either way, great success has been reached by following it and it may just make a huge difference in the sufferers life. Note, it is rather the combination of the “total attack”, than any specific aspect of the following that makes the difference for the sufferer:

  1. Start a dedicated, 4-5 day a week intense training program.
  2. Start using Co-Enzyme Q10, Ecklonia Cava Extract and Omega 3.
  3. Follow a lifestyle change in your eating program (+ lots of water and potent multi vitamin).gert7

Training for Fibromyalgia.

Yes it will be painful. To get past the first two weeks or so you might consider anti-inflamatories.

But training will be your most powerful tool in dealing with Fibromyalgia…any sufferer who train intensely will confirm this. Being very fit makes it MUCH easier to cope with the pain. The workouts also helps you cope mentally and emotionally much better with Fibromyalgia. Training also relieves all those feel good hormones that puts Fibromyalgia in the backseat.

The more intense the training the better. I would clearly suggest a good mix between resistance and cardio type training.gert1

Co Enzyme Q10 for Fibromyalgia

Scientists in Sevilla, Spain (2010), demonstrated increased oxidative stress and reduced coenzyme Q10 levels in the cells of some fibromyalgia patients. But they also demonstrated that coenzyme Q10 does not prevent or cure fibromyalgia.

Coenzyme Q10, or CoQ10, is synthesized by your cells using the same metabolic pathway that produces cholesterol. CoQ10 can also be obtained from foods, such as fish, organ meats and whole grains, or from supplements. CoQ10 serves two critical purposes in your body: it acts as a cofactor for the enzymes that produce high-energy molecules called adenosine triphosphate, or ATP, in your mitochondria, and it functions as an antioxidant in your tissues. CoQ10’s ability to simultaneously do these two functions could prove beneficial for some people with fibromyalgia.

(Read more: http://www.livestrong.com/article/466161-q10-for-fibromyalgia/#ixzz2KPYQ6eJC)

I personally know of quite a few Fibromyalgia sufferers who had good success with CQ10 at dosages varying between 200mg to 300mg per day spread out to 3 times a day after meals. They mentioned that within 48 hours after stopping the CQ10, the intense pain of the Fibromyalgia returned. Your local pharmacy should have various over the counter CQ10 available.

Ecklonia Cava Extract for Fibromyalgia

“In an eight-week, double-blind, placebo controlled study, Ecklonia Cava Extract demonstrated profound benefits in a group of established fibromyalgia patients. It reduced the time it took participants to fall asleep, and increased overall nighttime sleep. It improved soundness of sleep and boosted energy levels. Study participants also reported more good days per week, reduced pain, and an improvement in their general condition.”

For the Fibromyalgia sufferer, it is a must have supplement, a super antioxidant.

Suggested dosages 800mg after morning, midday and evening meal.

Together with CQ10 it provides a powerful weapon for the sufferer.

Omega 3 for Fibromyalgia

Omega-3 fatty acids inhibit inflammation and may reduce the amount of pain suffered in fibromyalgia. 2 x 2g after each meal 3 times a day. In combination with CQ10 & Ecklonia Cava it attacks the Fibromyalgia symptoms on various levels.

Lifestyle eating change for Fibromyalgia

A lifestyle eating change will not necessarily cure of relief pain, but due to its healthy eating habits it will make sure the body is feed correctly and as such give the body with a lot of tools needed to fight the condition. Part of this lifestyle eating plan is to get a potent daily multi vitamin as well as LOTS of water (2L-4L). The water is required to “flush” your system and help remove the bad stuff from your body. As you start loosing fat in your new lifestyle endeavour, the body will be faced with larger than normal amounts of “bad stuff” that was stored with the fat. Good daily water intake help to get this out of your system effectively.

The CQ10, Ecklonia Cava, Omega 3 and lifestyle eating change with intense training can potentially change the life of Fibromyalgia sufferers.

Anabolics and other banned substances for Fibromylgia

Ahhh, the sorted topic of anabolics, but the truth is some people with Fibromyalgia (especially men), have experimented with Anabolic Steroids and Human Growth Hormone (HGH) in treating Fibromyalgia and they swear by it, but some doctors are sceptical although I have spoken to a few that say they can see a possible link due to the fact that both anabolics and HGH primarily stimulates muscle growth, add a feel good factor and positive feeling with enhanced energy levels, etc…

What must be noted here is that nearly no scientific research has been done about Fibromyalgia and anabolics/HGH.

I have personally spoken to people who claim that a combination of anabolics and HGH makes the pain and other Fibromyalgia symptoms much more bearable and also give them a new lust for life.

It is an expensive route which might have some bad pitfalls for the user who do not know the substances and its side effects well. So it must be used with caution.

Although the lack of medical research and some scepticism from some medical doctors raise a question mark, it does sound not too far-fetched that these substances might have some positive effect in treating Fibromyalgia since both these substances have a direct impact and effect on the musculature structure of the body and energy levels. For those at the end of the road struggling to cope with the pain, it might just be a last option to try. But again…take care. I can suggest the safest route to you with these substances (there are many anabolics and many behaves differently and have different danger levels) but I would strongly suggest it being done under doctors supervision. Contact me if you need some help.

 

Some unconfirmed routes for fibromyalgia treatments are multiple “life bee stings” and medical marijuana.

 

I truly hope this article may help some Fibromyalgia suffers out there…and if you know of someone, please pass on the info. I know some of these sufferers and it is not something I wish on my enemy.

 

Happy training without pain!

Gert Louw

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