Tag Archive: ala



Please click here to watch video “CUTTING EDGE SUPPLEMENTS AGAINST PAIN AND CANCER”

When one reaches over 40 and especially over 50 then there are two major concerns that becomes reality for many, constant daily pain and for some the dreaded cancer!

All is not lost. Well for some it is…when one continue on an unhealthy living path (smoking, drinking, and no exercise) well, then the future unfortunately looks a bit bleak.

But just the other day I met a 92 y/o guy, fit, very mobile, with it! So certain things can be done to limit your risks and enhance your quality life.

However even if you do that, constant pain in joints/muscles seems to be part of any person over 40’s life. And so does the possibility of getting cancer.

We use to think it is just by the “throw of a dice” luck that we do not get cancer. But alas, there might just be a way out! Yes you hear right there just might be a very (!) powerful tool in your arsenal that limits your risk for cancer DRASTICALLY.

The same goes for the constant pain. There are 2 weapons in your arsenal to fight this rather effectively.

But first, let’s lay the basic groundwork.

Alpha Lipoic Acid & Potent Multi Vitamin

Two health supplements that form the basis of good health is a good/potent multi vitamin and ALPHA LIPOIC ACID. The best two choices for a potent multi vitamin is OPTIMEN or ANIMAL PAK.

Take the multi vit as directed on the container (must be after meal).

Why the multi vit – well simple you need to ensure that all the basis are covered concerning vitamins and minerals. Just short of one of these can have real bad consequences. This is very important for the older individual. You CANNOT rely on your food to get everything in.

Alpha Lipoic Acid must be taken at 200mg after morning meal and after evening meal.

Why Alpha Lipoic Acid?

Based on evidence from animal and human studies, lipoic acid offers the following essential health benefits:

  • Reduces oxidative stress in the body via powerful antioxidant activity
  • Improves several components of the metabolic syndrome—a combination of risk factors that increases one’s risk for diabetes
  • Reduces blood pressure
  • Reduces insulin resistance
  • Improves the lipid profile
  • Reduces weight
  • Increases insulin sensitivity
  • Improves diabetic neuropathy
  • Protects against cataract formation
  • Improves visual function in glaucoma
  • Helps prevents retinal cell death when combined with vitamin E in retinitis pigmentosa
  • Reduces brain damage after a stroke
  • Prevents bone loss, possibly through an anti-inflammatory effect
  • Removes toxic metals from the body
  • Reduces frequency and intensity of migraines
  • Improves skin texture

Now on to powerful pain relievers (although Alpha Lipoic Acid also play a role to relief pain).

MSM (Methylsulfonylmethane)

The first one is MSM. Now you might have heard about it. But the truth is, IT DOES WORK. But, not immediately. It is not like popping a pain-pill. It is more like reprogramming your body first before it takes effect.

Some of the most common uses for MSM include treating:

  • chronic joint pain (osteoarthritis, joint inflammation, rheumatoid arthritis)
  • leaky gut syndrome and autoimmune disorders
  • osteoporosis and susceptibility to bone fractures
  • bursitis, tendonitis, the development of scar tissue and other musculoskeletal pains
  • allergies and asthma
  • yeast infections
  • muscle cramps
  • constipation, ulcers, upset stomach, indigestion
  • PMS symptoms (cramps, headaches, water retention, indigestion)
  • stretch marks
  • hair loss
  • skin problems including wrinkles, sun burns (it offers some protection against UV light/wind burn), wounds, cuts, skin abrasions
  • eye inflammation
  • poor circulation
  • high blood pressure
  • fatigue
  • oral infections, toothaches, gum disease/periodontal disease

Three uses that MSM has gained the most notoriety for include: acting like an anti-atherosclerotic (preventing the hardening/thickening of arteries), chemo-preventative compound and natural anti-inflammatory. MSM seems to help the body’s natural free radical-scavenging, which means it lowers oxidative stress as the many ailments that come along with it. It’s an effective anti-inflammatory because it blocks the release of pro-inflammatory mediators and down regulates certain harmful signals sent from the immune system that can affect the entire body.

According to the Arthritis Foundation, based on the most reputable studies conducted so far on MSM — such as a 2006 pilot study that analysed the effects of 6,000 milligrams of MSM taken daily by patients with osteoarthritis — it effectively helps improve symptoms of pain and physical function without any major side effects.

That being said, MSM is capable of causing mild side effects for some people, including indigestion, upset stomach or diarrhoea. It’s also not suitable for people taking blood-thinner medications. If you’re pregnant, you’ll want to speak with a doctor before taking it regularly.

Lastly, MSM does NOT start working immediately. It takes up to 3 months for it to start working effectively. For some up to 6 months. So although there is a considerable lead time…it really is worth investing in the long term in using MSM because it IS a powerful pain suppressant with many other health benefits.

Co Enzyme Q10

Now an even more interesting product, Co Enzyme Q10. [Suggested: 150mg after morning and evening meal]

I have written about this wonder supplement in the past and I consider it the “mother of all supplements”. None comes close to it in effectiveness and health boosting ability. And to top it off, it is a significant pain suppressant. To such an extent that many doctors are now at long last starting to subscribe CQ10 to their migraine patients.

Coenzyme Q10 is a mitochondrial energizer that has shown remarkable effects against common heart ailments and neurological disorders. In just the past year, scientists have uncovered specific mechanisms indicating that CoQ10 may have a role in fighting certain cancers. Most surprising, however, are new studies that show how CoQ10 guards against a wide array of common age-related disorders. In this article, we summarize recent discoveries that significantly broaden the clinical utility of CoQ10.

Guarding the Brain After Cardiac Arrest

People who survive cardiac arrest often suffer irreversible brain damage as a result of the disruption of oxygen to the brain. European researchers recently investigated whether combining CoQ10 with mild hypothermia—a technique proven to reduce neuronal damage and increase survival—might enhance the effects of that treatment.

Forty-nine patients who had suffered cardiac arrest and then received cardiopulmonary resuscitation were randomly selected to receive hypothermia (reduction of body temperature) treatment plus CoQ10 or hypothermia plus placebo. The hypothermia treatment involved the patients being placed on a body-surface-cooling mattress.

The patients were then administered either liquid CoQ10 (250 mg followed by 150 mg three times daily for five days) or a placebo through a nasogastric tube. The remarkable findings showed that three-month survival in the CoQ10 group was 68%, compared to only 29% in the placebo group. Coenzyme Q10 thus helped reduce the death rate from cardiac arrest by an astounding 57%. The researchers also found that 36% of patients in the CoQ10 group had a good neurological outcome at three months, versus only 20% in the placebo group.

Preventing the Onset of Migraine

Migraine headaches are a debilitating, all-too-common affliction. Because mitochondrial dysfunction may play a role in migraines by limiting oxygen metabolism, researchers recently explored the use of CoQ10 in preventing these headaches. Published in the February 2005 issue of Neurology, the research describes a placebo-controlled trial of 42 patients in Switzerland.

Patients who had suffered migraines for a year or more, with two to eight attacks per month, were randomly assigned to receive either 100 mg of CoQ10 or placebo, three times daily. At the end of the three-month trial, the CoQ10-treated group had lower attack frequency and fewer headache days and days with nausea than did the placebo group. The mean number of monthly migraine attacks dropped from 4.4 to 3.2 in the CoQ10 group, compared to a negligible decrease from 4.4 to 4.3 in the placebo group.

In this study, supplemental CoQ10 reduced migraine frequency by 27%.

Slowing Early Macular Degeneration

Age-related macular degeneration is the most common cause of vision loss in people over 60. With the deterioration of the macula (a tiny cluster of highly specialized cells in the retina) central vision progressively begins to blur. As the disease worsens, central vision loss may increase until it becomes impossible to perform tasks that require detailed vision, such as driving and reading.

In recent years, researchers have focused on how oxidative damage affects age-related macular degeneration. The eye, one of the body’s most metabolically active organs, not only generates an enormous amount of free radicals through normal function, but also incurs additional oxidative damage from ultraviolet radiation and air pollution. In recent trials, the use of antioxidants has been shown to counter age-related macular degeneration. For example, in an 11-center, double-blind clinical trial conducted by the National Eye Institute (a division of the National Institutes of Health), a combination of antioxidants plus zinc slowed macular degeneration progression in people with intermediate or advanced disease by about 25%.

Hungarian scientists are now exploring a metabolic rather than an antioxidant approach to managing macular degeneration. Citing findings that mitochondrial dysfunction might also play a role in the development of the disease, the researchers designed a clinical trial to evaluate intervention in early age-related macular degeneration with a combination of compounds—including CoQ10—that have demonstrated the ability to improve mitochondrial metabolism. The researchers reported results of their double-blind, placebo-controlled trial last year in the journal Opthalmologica. More than 100 patients with early age-related macular degeneration were randomly assigned to receive either two capsules per day containing 200 mg of acetyl-L-carnitine, 780 mg of omega-3 fatty acids, and 20 mg of CoQ10, or capsules containing an equal quantity of soy oil.

At the end of the 12-month treatment period, the researchers found statistically significant improvement in the treatment group as measured by all four parameters of visual function studied. In addition, only one of the 48 patients (2%) in the treatment group showed clinically significant worsening in visual field mean defect (blind spots in the visual field), the primary study endpoint, compared to 9 of 53 patients (17%) in the placebo group. The decrease in drusen—tiny yellow retinal deposits associated with macular degeneration—of the treated eyes was also statistically significant compared to placebo when either the most-affected eyes or the less-affected eyes were considered. In the less-affected eyes, the drusen-covered area decreased by 23% in the treated group, but increased by 13% in the placebo group. These findings suggest that intervention with an appropriate combination of nutrients that affect mitochondrial lipid metabolism may stabilize and even improve visual functions in early age-related macular degeneration.

New Applications in Fighting Cancer

Research on CoQ10 and cancer has focused on two lines of inquiry: CoQ10’s ability to improve immune response and its ability to decrease the cardiotoxicity caused by a common class of anti-cancer chemotherapeutic agents.

Patients with cancer often exhibit low levels of CoQ10,6,7 and researchers have shown that CoQ10 can increase immune response in humans.

Based on these findings, Danish researchers investigated CoQ10’s effects alone and in combination with other nutrients as an adjunctive therapy for breast cancer.

In one case report, the researchers describe three breast cancer patients with metastasized cancer. The women underwent conventional cancer treatment and supplemented with a daily dose of 390 mg of CoQ10. All three women demonstrated tumor regression and decreased incidence of metastasis.

In another study, the same research team investigated 32 high-risk breast cancer patients whose malignancy had spread to the lymph nodes. In addition to conventional therapeutic interventions, this group of patients received a daily combination of nutrients (vitamin C: 2850 mg; vitamin E: 2500 IU; beta-carotene: 32.5 IU; selenium: 387 mcg; and secondary vitamins and minerals), essential fatty acids (1.2 grams of gamma linolenic acid and 3.5 grams of omega-3 fatty acids), and 90 mg of CoQ10. At the end of the 18-month trial, six patients showed apparent partial remission, none of the patients showed signs of additional metastases, and their quality of life improved. None of the patients died during the study period, though four deaths were expected based on the patients’ disease stage. In one of the six patients with partial remission, the dose of CoQ10 in the nutritional protocol was increased to 390 mg. After two months, that patient’s tumor had disappeared completely, as confirmed by a mammogram.

While chemotherapy drugs can be highly effective, their use can also be limited by toxic side effects. This has been noted in the case of anthracyclines, a class of drugs widely used in cancer chemotherapy. These drugs have demonstrated efficacy in the treatment of leukemia, lymphomas, and solid malignancies, and are often used to treat breast cancer, with higher doses yielding greater clinical responses. These higher doses of anthracyclines, however, can produce toxic effects on heart tissue, possibly leading to cardiomyopathy and heart failure that are not responsive to conventional pharmacological interventions. In fact, anthracyclines selectively damage mitochondria in the heart, but not in other organs. Since coenzyme Q10 supports both heart tissue and mitochondria, researchers conducted human trials to determine whether CoQ10 might prevent cardiotoxicity during the administration of anthracyclines.

Two recent review articles addressed CoQ10’s potential as an adjunctive therapy during chemotherapy with anthracyclines. Writing in the Journal of Clinical Oncology, researchers summarized five reviewed studies in which CoQ10 was given along with anthracyclines. They report that in three of the studies that measured heart rhythm, patients who received CoQ10 showed favorable changes suggesting that CoQ10 might have a stabilizing effect on the heart. They also note that supplementation did not interfere with anthracycline treatment, and that no adverse effects were reported in any of the trials. The authors concluded that although coenzyme Q10 demonstrates potential for reducing cardiotoxicity, larger and more rigorous investigations are needed.

Slowing Neurodegenerative Disease Progression

Many investigators have conducted preclinical studies examining how oxidative stress and impaired mitochondrial function may contribute to neuronal cell death, a characteristic of Parkinson’s, Alzheimer’s, and other neurodegenerative diseases. For example, a recent journal article in Toxicology and Applied Pharmacology reported on the effects of the herbicide paraquat on neuronal cell death in the laboratory. The researchers found that this toxic chemical damaged mitochondria and increased free radical production, eventually resulting in the death of neuronal cells. Pretreatment of the cell cultures with CoQ10, however, inhibited both mitochondrial dysfunction and free radical generation. The researchers postulated that coenzyme Q10 may prove useful in preventing and treating neurodegenerative conditions related to environmental toxins.

While published research on the use of CoQ10 in slowing the progression of Alzheimer’s disease has been limited to preclinical studies, investigations of CoQ10 and Parkinson’s disease have moved into clinical trials, including randomized controlled studies. This work has been led by Clifford Shults, MD, professor of neurosciences at the University of California at San Diego School of Medicine. In Parkinson’s disease, brain cells that produce the neurotransmitter dopamine progressively die. Research in animals has shown that CoQ10 can protect the substantia nigra, the area of the brain where these cells reside. Studies by Dr. Shults and others have shown that mitochondrial dysfunction and diminished mitochondrial CoQ10 levels frequently occur in Parkinson’s sufferers.

With funding from the National Institute of Neurological Disorders (a division of the National Institutes of Health), Dr. Shults and his colleagues undertook the first double-blind, placebo-controlled, multicenter clinical trial of CoQ10 in patients with early untreated Parkinson’s disease. In this phase II, dose-finding study, 80 patients were randomly assigned to receive one of three different CoQ10 doses (300 mg/day, 600 mg/day, or 1200 mg/day) with vitamin E, or a placebo containing vitamin E alone. The patients were followed for 16 months or until the participants required levodopa, a standard drug treatment for managing disease symptoms.

The results, reported in the Archives of Neurology, showed that patients who received the largest dose of CoQ10 (1200 mg/day) had 44% less decline in mental function, movement, and ability to carry out activities of daily living than those who received the placebo.19 Patients who received CoQ10 doses of 300 mg/day and 600 mg/day also showed some slowing in decline compared to the placebo group, but not as much as those who took the highest dose. The authors concluded that CoQ10 was safe and well tolerated at doses up to 1200 mg/day.

A clinical trial has also been undertaken in patients with Huntington’s disease, a neurodegenerative genetic disorder. This trial, conducted by the Huntington Study Group, randomly assigned 347 patients with Huntington’s disease to receive CoQ10 at 600 mg/day, remacemide hydrochloride at 600 mg/day, a combination of both, or placebo. Over the 30-month trial, the CoQ10 treated patients showed a 13% decrease in overall functional decline and beneficial trends in some secondary measures. However, the difference between the CoQ10 group and the other groups did not reach statistical significance.

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METFORMIN

Now on to the last miracle supplement. Metformin [suggested 500mg daily]

This is actually not a supplement but a prescribed medicine for diabetics. However it seems to do much more than just treating diabetics and all of it is good, very good news!

Let me give you the rundown…

[From the US National cancer institute]

“In 1957, the first results from a clinical trial of the diabetes drug metformin in patients were published. Yet, it would take nearly 40 years for the drug to be approved in the United States as a treatment for type 2 diabetes.

Now researchers want to know whether this decades-old drug may have additional uses in another disease—cancer. Based on findings from a number of large epidemiologic studies and extensive laboratory research, metformin is being tested in clinical trials not only as a treatment for cancer, but as a way to prevent it in people at increased risk, including cancer survivors who have a higher risk of a second primary cancer.

Numerous early-stage clinical trials are currently under way to investigate metformin’s potential to prevent an array of cancers, including colorectalprostateendometrial, and breast cancer. Several of these trials are being funded by NCI’s Consortia for Early Phase Prevention Trials. And NCI is collaborating with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to study participants from the landmark clinical trial, the Diabetes Prevention Program (DPP), to investigate metformin’s impact on cancer incidence.

Some of the early-phase prevention trials of metformin are enrolling participants who are at increased risk for cancer and who are obese, have elevated glucose or insulin levels, or have other conditions that put them at risk for diabetes.

“With the obesity epidemic, these studies are applicable to a substantial portion of the U.S. population and, increasingly, of the world population,” said Brandy Heckman-Stoddard, PhD, MPH, of NCI’s Division of Cancer Prevention.

Expanding the Data Pool

Much of the human data on metformin and cancer has come from epidemiologic studies of people with diabetes. In many, though not all, of these studies, people with diabetes who were assigned to take metformin had a lower incidence of cancer than those taking other diabetes drugs.

Completed in 2002, the original DPP enrolled more than 3,200 people at increased risk of developing diabetes and randomly assigned them to one of three groups: one group received metformin, one took part in an intensive diet and physical activity program, and one received a placebo. Participants in the metformin arm had a substantially lower risk of developing diabetes than the general population; participants in the exercise and diet regimen fared even better.

With NCI’s involvement, the program’s extension, called the DPP Outcomes Study, will allow investigators to document cancer incidence and death among study participants. Those observations should provide some of the strongest data available to date on metformin’s anticancer effects in people without diabetes, explained Dr. Heckman-Stoddard. The first data on cancer outcomes in study participants, which will be based on 15 years of follow-up, should be available in 2014.

“Once we have that data, there are a host of other questions we can ask,” she said. For example, Dr. Heckman-Stoddard and her colleagues plan to study metformin’s impact on certain blood biomarkers that studies have suggested are associated with cancer risk. They will also study the drug’s mechanism of action—that is, how metformin may work to prevent changes in cells that can lead to cancer.

For Prevention, Small Biomarker-Driven Trials

The smaller prevention trials being conducted are very different from the DPP Outcomes Study. These trials are not designed to determine whether metformin prevents cancer. Prevention trials must generally have a large number of participants and span many years to show whether a drug or some other intervention reduces the risk of cancer.

Instead, these short, 3- to 6-month trials are investigating whether the drug has an effect on specific proteins and/or signaling pathways that have been implicated in cancer development and that laboratory studies have shown are affected by metformin.

At the University of California, Irvine Chao Family Comprehensive Cancer Center, for example, Jason Zell, DO, MPH, is leading an early-phase clinical trial that is testing metformin’s effect on the mTOR signaling pathway in obese people who have previously had precancerous growths removed from their colons.

Numerous studies have implicated the mTOR pathway as an integral hub in cancer development and progression, and laboratory studies have consistently shown that metformin can blunt mTOR signaling.

“The key point of the trial is to get at the mechanisms of action … to see if metformin is behaving in the expected manner” based on the lab findings, Dr. Zell explained.

Numerous early-stage clinical trials are currently under way to investigate metformin’s potential to prevent an array of cancers, including colorectal, prostate, endometrial, and breast cancer.

Dr. Zell and his colleagues chose to study obese patients “because of the interesting side-effect profile of metformin, which can include weight loss,” meaning it may not be suitable for underweight, nondiabetic individuals, he continued.

If this first trial shows that metformin is having the expected effects on mTOR signaling, the next trial would be similar but would measure a clinical outcome, such as whether metformin decreases the number of colorectal polyps that return.

phase II trial at the University of California, San Diego Moores Cancer Center is testing metformin’s effects on a host of biomarkers in postmenopausal breast cancer survivors who are obese.

Funded by NCI’s Transdisciplinary Research on Energetics and Cancer (TREC) program, the trial, called Reach for HealthExit Disclaimer, will involve treatment with metformin alone and in combination with an exercise program. The study will examine the effect of 6 months of metformin treatment, with or without exercise, on a host of biomarkers associated with cancer risk. The change in biomarker measurements before and after treatment will be compiled into a score that predicts the risk of dying from breast cancer.

This is all part of the trial’s novel “biomarker bridge” design, the lead investigator, Ruth Patterson, PhD, explained. The biomarkers and the risk score are being derived from an analysis of tissue samples collected as part of an NCI-supported phase III trial called the Women’s Healthy Eating and Living (WHEL) study. This study found that a diet low in fat and high in fruits and vegetables did not reduce the risk of cancer returning in survivors of early-stage breast cancer compared with survivors who maintained their normal diet. Researchers have continued to follow the health of WHEL participants to document their health outcomes, including death from breast cancer.

“The WHEL trial is over, and we have a freezer full of blood samples, and we know participants’ breast cancer recurrences, mortality, and other outcomes,” Dr. Patterson said. “So we’re hooking together a short-term trial with a long-term cohort study by means of blood biomarkers.”

The Dose Is the Question

Most of the cancer clinical trials of metformin use the same doses typically used to treat diabetes. That makes sense, because all of the epidemiologic data suggesting a cancer benefit came from studies that used those doses, said Michael Pollak, MD, of McGill University in Montreal, who has extensively studied metformin and its anticancer potential.

“We already know that those doses are safe, so why not study them?” Dr. Pollak continued. “But then you have to realize that virtually all of the lab studies [of metformin] have been done using drug concentrations that are as much as 100-fold higher than those found in the serum of diabetic patients. So the lab studies do not directly justify the clinical trials that are using conventional antidiabetic doses.”

With the obesity epidemic, these studies are applicable to a substantial portion of the U.S. population and, increasingly, of the world population.

—Dr. Brandy Heckman-Stoddard

Although laboratory studies suggest that larger doses of metformin “deserve study” for cancer treatment, Dr. Pollak noted that “for cancer prevention, we can only consider the hypothesis that the antidiabetic dose, or even lower doses, will be clinically useful.”

Dr. Zell agreed. “In the realm of cancer prevention, where side effects are less acceptable than they are in the realm of cancer treatment, the conventional dose for treating diabetes or something close to it may be the limit.

“I don’t imagine that prevention researchers will be looking to use [significantly larger] doses of metformin,” he continued. “In a healthy population, even a low risk of side effects could be extraordinary when applied to a larger population…. That’s why trials like ours are important. At the end of this 12-week intervention, we’ll have a good idea of whether the standard dose of metformin can affect cancer signaling pathways.”

Early Days

It’s still far too early to tell whether there is any future for metformin as a means of preventing or treating cancer, several researchers said.

Despite the very strong epidemiological evidence, there’s a chance that, even if metformin has some ability to prevent cancer, its efficacy may be limited to just several cancer types, Dr. Pollak noted. For example, metformin is not absorbed very well by the body and is absorbed differently by different tissues, he explained, which could limit how effective it might be against particular cancers.

Although the drug in its current form has certain limitations, some investigators are working on developing more potent derivatives of metformin. At the 2012 San Antonio Breast Cancer Symposium, for example, Italian and U.S. researchers reported that several metformin derivatives they had developed potently blocked the growth of breast cancer cells in the laboratory, including cell lines of triple-negative breast cancer, and caused the cells to die.

To be used for cancer prevention, any metformin derivative would have to be safe, with few side effects, Dr. Heckman-Stoddard stressed. As for the original metformin formulation, she added, current trials should help to map the way forward for its use in prevention.

“It’s important that we identify the right populations in which this is most likely to be an effective agent,” said Dr. Heckman-Stoddard. “We need to look at the evidence from all of these early-phase trials as a whole,” she continued, including examining the population groups exhibiting the strongest suggestions of efficacy “so we can design efficient phase III trials.”

Examples of Clinical Trials Testing Metformin for Cancer Prevention

Trial Phase Measured Endpoints Sponsor
Exercise and Metformin in Colorectal Cancer Survivors II Insulin levels and other biomarkers Dana-Farber Cancer Institute
An Endometrial Cancer Chemoprevention Study of Metformin [and Lifestyle Intervention] III Biomarkers in the endometrium and insulin levels University of Texas MD Anderson Cancer Center
Metformin as a Chemoprevention Agent in Non-Small Cell Lung Cancer II Progression of potentially precancerous bronchial lesions (secondary endpoint) in patients who have undergone surgery for lung cancer Mayo Clinic
Prostate Cancer Active Surveillance Metformin Trial II Progression of prostate cancer in men undergoing active surveillance for low-risk disease University Health Network, Toronto
Metformin Hydrochloride as Chemoprevention in Patients with Barrett Esophagus II Changes in the levels of the signaling pathway protein pS6K1, thought to play important role in progression to esophageal cancer Mayo Clinic”

 

The bottom line is that Metformin has already proven to be a powerful tool against some of the most common cancers.

Here is a article by Medscape on whether everyone should be taking Metformin due to it’s incredible benefits: http://www.medscape.com/viewarticle/835676

 

WANT A HOLISTIC TRANSFORMATION SYSTEM FULLY CUSTOMIZED?  The program I am following for the past 6 years (age 46 to 52), available now fully customised on all levels. before-and-after-dec2016Every little secret, every hard-earned practical fact, every scientific study that actually support the (very) few supplements between all the thousand ridiculous advertisement claims have been filtered en incorporated into one system that MAKES A DIFFERENCE click here: 

https://gertlouw.com/my-transformation-secrets/

 

Metformin has been proven to be very safe even for non-diabetics. But since it is a prescription drug you will have to twist your doctor’s finger to get a prescription. Ask him to look at the anti-cancer and weight-loss properties of Metformin…this might change his mind.

So here you have it – 5 powerfull tools in your arsenal for good health, anti pain and anti cancer. As the Vulcan say “Life long and prosper!”

Happy Training

Gert Louw

Gert Louw video cover


This is where a LOT of dedicated people get derailed completely! They get sick or injured and well, that is where their road to transforming the body stops…dead in it’s tracks. Until that point they are so motivated and charged up and then that happens…and the de-motivation is just too much. They just never get it off the ground again afterwards.

Right now, I am down from gym with kidney infection and this will keep me out of gym for close to 7 days. But after the 7 days off, I’ll be back doing one week light work and then all back to normal.

Not ONE of us are spared sickness or injuries. Now, injuries we can manage better especially with applying more wisdom as we get older (warming-up, stretching and simply avoiding high risk exercises for injury). But sickness is difficult to prevent. Sure we can apply the basics (anti-oxidants, multi-vit, CQ10 and ALA) and wash our hands regularly with anti-bacterial soap/spray, but even with that, chances are we will still get flu in the winter and still get the odd infection.

It is not a matter of preventing sickness and injuries but a matter of accepting that they form part of the training/body transformation environment as a given. You WILL get sick and you WILL get injured. But that must never (!) derail your efforts. Accept that it will push you back one to two weeks. Do not allow yourself to get negative about it, it is PART of the whole process and those with a winning mindset accepts that!

Now, what is even more important is that after a week of sickness, be careful to go in full force back to gym. Your body is still weak and in a process of recovery. Your immune system not nearly back to normal. Pushing yourself to the limits the first week back can and most probably will result in a recurrence of the sickness even to a worse degree putting you out gym for 3 weeks or more. That first week back after being sick make sure you do not do more than 50% your normal capacity. Go through all the motions and exercises but keep the exertion levels low.

Then the 2nd week back in training you will find you feel yourself again. That is where you start pushing the limits again.

A KEY ingredient of the winning mindset is to force yourself to stick 100% to your diet while sick or injured. Doing this will go great lengths to keep the motivation levels high! This is NOT the time to binge or eat what you want. This is the CRITICAL time to feed the body correctly. Sometimes I experienced when going back after a week sick I actually am in better shape than before, simply because of the control I had with my diet and my body that actually had a well deserved break!

Now, my timing for my kidney infection is real bad because 21st May I got a photoshoot coming up. But that is where all your hard work you have put in over the previous months and years will show the dividends…

Wish you all good health and injury free training!

Gert Louw

http://www.gertlouw.com

Gert Louw INJURY


This is probably the single most confusing area for anyone want to venture the road of fitness/bodybuilding or just to transform their body for a “wow” look.

 

The first question is, “Do I need to take supplements at all”?

Now those of you that have followed me for a while know that I am very (!) outspoken against supplements. My photos have been stolen and abused with fake stories by supplement companies more than 80 times now (those are the one’s I actually busted, let alone the one’s I don’t know about).

So the bottom line is EVERY advert you read about how great this or that product is, is hugely inflated and chances are very high the photos produced as proof are stolen and the stories as proof are fake. There is NO (!) magic pill out there. Not even anabolic steroids can do what some of these supplement companies claim, ie: “complete body transformations in 14 days or 3 weeks”!

So lesson one – NEVER read supplements advertisements. It has 90% lies and 10% truth. Very few real advances have been made in the last decade or so about supplements for bodybuilding. I am not talking about hollow claims, but I am talking about real scientific independent studies and proof.

Those that is going to believe me and listen to what I say will save THOUSANDS of dollars!

Bodybuilding and fat loss supplements contribute a miniscule 2.5% to your overall results. Thus, you CANNOT waste your money on any supplement that is not highly effective and focused.

Now all that being said, truth is, there are a core group of supplements for both your general health (very important for those putting their body under strain due to heavy training and dieting) and for creating and environment for muscle-building and fatloss and increase your repair ability of your body.

Anything outside these groups of supplements you need to question and REALLY do your homework before parting with your hard-earned money.

Click here to view video “How to choose the RIGHT supplements for muscle building and fat loss”

 

Regarding BRANDS

Now generally anyone knowing me, knows that I am steering clear here because I do not like promoting brands and shooting others down. BUT, I had so many people ask me about safer brand options. So here is my opinion:

Experience and knowledge leads here. Let me explain. NO supplement out there, with little to no scientific studies to back it up, can make any significant difference no matter what the marketing or claims are.
The are MANY, MANY scam supplements out there that are totally worthless and it cost and arm and leg.
So the first rule is, it MUST be backed up by various independent scientific studies and control groups. This immediately cancel 95% of supplements!
The rest well, there are various degrees of success. Even if it is backed up by solid studies, if the effect is minimal, one is wasting your time and money.
The supplement must have a significant effect to be even considered.
Now, filtering through everything with the above rules and the supps I suggest are the ones that can and will make an ever so slight but important difference (see section below). The only one outside of this group is creatine…for about 90% of people it can have solid advantages (even to the degree of the most potent supp this side of anabolic steroids)…but that should only be used while on a building phase and not cutting phases. Just a note on creatine – anyone with kidney issues should steer clear…creatine is placing some strain (albeit moderate) on the kidneys. So drink LOTS of water while on it.
When buying the “approved” supplements…stick only to highly reputable BIG brands, EAS, On Nutrition, Animal and Muscletech.
That does not mean all the supplements these companies sell, is working…they sell whatever the public has been brainwashed to buy! So tread carefully!
Which brand I use? A local, South African brand – HMT, but you will only have access to it if you are in South Africa and the range is designed specifically for competing athletes.

 

INTERESTED IN MY ONLINE COACHING SYSTEMS – TRANSFORMING YOU BODY? CLICK HERE advanced coaching and body transformation systems

 

First, let’s look at GENERAL HEALTH supplements (supported by science and real world trials)

 

CQ10 (Co-Enzyme Q10) – the number ONE potent health supplement out there. [150mg – 300mg daily]

“Coenzymes are substances that help the activities of enzymes. Evidence shows that Coenzyme Q10 plays a very important role in the production of energy throughout the body. It also has been found to have powerful antioxidant effects, destroying free radicals in the body.

Improved energy production is of particular importance to athletes and bodybuilders.

Coenzyme Q10 helps the body convert food into energy in the form of ATP. Nearly every cell in the body contains at least some Coenzyme Q10, with mitochondria, the energy powerhouses of cells, containing the most. The heart and liver, due to their high content of mitochondria, contain the most Coenzyme Q10 out of any organs in the body.

In a placebo-controlled study, Coenzyme Q10 supplementation was shown to help people with congestive heart failure. People with congestive heart failure may not see any results for a few months, but should not quit taking it immediately without consulting a doctor. People with angina have been able to exercise for longer periods of time and with more energy when supplementing with Coenzyme Q10. It has also been shown to lower blood pressure and improve the pumping function of the heart.

Coenzyme Q10 may even help facilitate weight loss due to its stimulating effects on the body’s metabolism. Evidence suggests that Coenzyme Q10 can help in a number of ailments and diseases including: diabetes, angina, give support with chemotherapy, male infertility, mitral valve prolapse, give support with HIV, gingivitis, and congestive heart failure.  The assimilation of Coenzyme Q10 may be better if taken with a fatty substance such as oil, peanut butter, olive oil, etc.”

CQ10 has also shown to have highly effective pain treatment properties, especially for migraine sufferers.

 

ALA(Alpha lipoic Acid) [200mg – 400mg daily]

“In addition to the anti-oxidant effects that ALA produces the list below shows why it is such an important supplement. The list of benefits includes:

  • Improving of physique
  • Combats free radicals
  • Protects our genetic material
  • Slows aging
  • Protects against heart disease
  • Protects against cancer
  • Improves skin and helps erase wrinkles
  • Regulates blood sugar in diabetics
  • Protects the liver
  • May be used as a treatment for Stroke

If Alpha-Lipoic Acid were just another antioxidant, then its value would be far less. After all, there are dozens of ingredients on the market that have powerful antioxidant functions. However, the unique qualities possessed by Alpha-Lipoic Acid, functioning as both a water- and fat-soluble antioxidant make it an intriguing ingredient and a supplement worthy of serious consideration.”

 

Omega 3+6 [2g to 6g per day]

“Omega-3 fats are essential fats your body needs for brain development that may also help limit your risk for heart disease. Good sources include flaxseeds, walnuts, salmon, herring, tuna, mackerel, sardines and other fatty fish. The Academy of Nutrition and Dietetics recommends getting at least 500 milligrams per day of EPA and DHA, the main omega-3 fats found in seafood.

Getting plenty of omega-3 fats in your diet may help increase your feelings of fullness, making it easier to lose weight and keep it off, according to a study published in Appetite in November 2008. A review article published in Nutrients in 2010 noted that omega-3 fats may help with weight loss by reducing appetite and increasing fat burning, especially when combined with a reduced-calorie diet and exercise.

Omega-6 fats are essential as well, but most people get more of these than they need in their diets. A high ratio of omega-6 to omega-3 fats, such as that found in the typical American diet, may increase inflammation and your risk of cancer, heart disease and arthritis. If you’re trying to lose weight, it may be best to limit your omega-6 consumption, which can cause you to retain water. Aim for a 3-1 ratio of omega-6 to omega-3 fats, recommends Unity Health System. These fats should make up between 5 and 10 percent of your total calories for the day. Some of the main sources of omega-6 fats include soybean oil, safflower oil and corn oil.”

Consumption of Omega 3 + 6 will actually help you to lose fat!

 

Potent Multi Vitamin [as directed on container]

When the body is under strain due to serious training and dieting, then you need larger amounts of trace minerals/vitamins to ensure that the body stays healthy. Some doctors lately actually support the notion that one does not need a multi-vitamin at all. However, I oppose this notion, especially when it comes to a body under strain. Potent type multivitamins contains higher dosages of all vit/min combinations than those used by non-active people. Just a note here: Never use anti-oxidants or Multi Vit in near to the time you train. It has been shown by recent science studies that this limits your body’s ability to lose fat. Use it as far removed from your training session. Good examples: Optimen, Optiwomen, Animal Pak, Nano Pack by Nuskin, etc…

 

Now, about supplements that can make a real difference in the bodybuilding/fat-loss environment:

BCAA – branched chained amino acids [use as directed on container – buy shake and not pill form]

BCAA shake while training has been proven scientifically to “force” your body’s energy requirements to come from the fat reserves and not the muscles. You NEVER want energy to come from the muscles, when that happens, you enter a catabolic state = smaller muscles! BCAA goes a long way to help stop this process and encourage energy to come from fat reserves. It is a critical component when you train heavy and intense and is best use while training in shake form.

L-Glutamine [5g before and 5g after training]

L-Glutamine has been proven through various science studies to be a miracle bodybuilding supplement.

  • Glutamine has been linked to protein synthesis. It prevents your muscle from being catabolic (eaten up) in order to provide Glutamine for other cells in the body.
  • Glutamine helps maintain cell volume and hydration, speeding up wound and burn healing and recovery.
  • Glutamine benefits you by replenishing declining Glutamine levels during intense workouts.
  • Research has shown Glutamine can help you produce growth hormone levels. A study has shown 2 grams of L-Glutamine increased growth hormones by over 400%.
  • Glutamine may serve to boost your immune system. For bodybuilders, this is important since heavy workouts tend to greatly deplete Glutamine levels. (Glutamine is a primary energy source for your immune system.)
  • Glutamine is one of the most important nutrients for your intestines. It has the ability to ‘repair a leaky gut’ by maintaining the structural integrity of the bowels.
  • Bet you didn’t know this: It can even cure ulcers! Studies have found that 1.6 grams of Glutamine a day had a 92% cure rate in 4 weeks.

Researchers are suggesting that Glutamine is the most important amino acid to the bodybuilder. It provides a component in muscle metabolism and cellular support not shared by any other single amino acid, making the benefits of L-Glutamine supplementation a realistic venture.

Glutamine has also various benefits for hiv+ people.

Whey protein [40g immediately after training]

Immediately after training you need to spike the insulin. This is to create a potent environment for growth. Insulin is the most powerful muscle-building hormone in the body. To do this, one consume 40g of whey protein (without added carbs or fats) and eat a banana or apple. This is a key aspect for anyone serious about building muscle and loosing fat. This will also feed the muscles very much-needed nutrients.

 

Creatine – optional [use as directed on container and pre load if necessary]

Creatine will work for some and for some not. For those that it does work, it can be the most potent muscle-building supplement this side of anabolic steroids. So it might be worthwhile to test out. Just be carefull, creatine places strain on kidneys and only use if you have healthy kidneys. Creatine must always be use together with grape juice or Vitargo for best absorption.

 

Ok, now you have some guidance about what to choose between all these 1000’s of supplements.

 

But just some food for thought about your plans to transform that body this year…

Everyone experience failure along the adventure of transforming their body, but those that get to the goal post are those that got up EVERY time after they failed on diet or training for a day or a week and kept going…THAT is the single biggest and most important ingredient for EVERYONE who reach the goal post of a “wow” transformation. Like a well-known slogan says: “JUST DO IT.” Don’t think about it…DO IT! The more you think about it, the more reasons you will find not too. Because it is an effort. It is not easy and it will take a lot of sweat and pain. But the adventure is incredible and will change your life forever. The return on your investment will be unbelievable! Reach for the stars, nothing less…

But to make it worthwhile, change everything…inside and out. become the best person you can be, with integrity, kindness and compassion, otherwise it is a hollow aim that will let you just become a more well-known jerk instead of a guy people look up to and admire for more than just their body. A role model that can change the world!

Here are 3 incredible transformation photos – look at them and burn them in your mind…GET TO THAT GOAL POST!

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Click here to watch video “HOW TO TRANSFORM TO A “WOW” PHYSIQUE”.

 

It can be done…but YOU will have to do it and MAKE IT HAPPEN.

For those that want complete customised transformation systems and diets to get you to the goal post, follow this link for some of the most comprehensive systems in the business: https://gertlouw.com/contact-me/

And lastly, here is my transformation pic (age 50 on the right):

 

gert b&A 12May2016 small

Make 2016 the year you become the best you can be…from the inside and outside!

Wish you all a great day.

Gert Louw


As the years progressed I’ve fine tuned my approach to pre & post workout supplements.

 

The regime I am currently following is highly advisable for anyone who wants to add maximum lean muscle with training. It keeps the body in a anabolic state with energy to spare and quick recovery of exercise induced muscle damage.

It sticks to the core, proven supplements. Keep it simple and stay away from all the fancy stuff with “too good to believe” marketing hype. It is ALWAYS “too good to believe” and ALWAYS utter lies no matter how many “proof” photos they attached (normally stolen) or stories (made-up)!

It is a great tool for the over 40’s or even over 50’s to add muscle. For the younger crowd it means perfect muscle growth environment.

PRE-WORKOUT – 30 to 45 minutes before training

Branched Chain Amino Acids (BCAA’s) 6-8 tablets

The BCAA’s ensure that the energy required during training  is not obtained from your muscles but forces it to obtain it from other places (fat storage, etc..) This protects your muscles from going catabolic during training. A critical supplement in your pre-workout arsenal. In-depth info about BCAA’s can be obtained from: http://www.bodybuilding.com/fun/bcaas-the-many-benefits-of-amino-acids.html

L-Glutamine 5g dissolved in water

When you train your Glutamine reserves of your body will drop very fast (!). When it becomes too low you will feel exhausted and have no stamina/power. When the Glutamine has dropped too low, muscle recovery will be very (!) slow and the body can take up to 6 days to replenish the levels of Glutamine to optimum again. During that time virtually no muscle growth will occur. It is therefore of the absolute importance that you supplement with L-Glutamine before training.

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AGMATINE 1g dissovled in water (together with L-Glutamine)

(In the video I say 1g to 10g Agmatine Sulfate. That is incorrect – the amount is only 1g of Agmatine Sulfate)

The following extract from http://www.bodybuilding.com/fun/jrod17.htm sums it up very nicely as to why specifically agmatine:

  1. Agmatine is a pain fighter. This can be beneficial to the athlete in two ways:
    1. It can potentiate the effects of analgesics used during recuperation from injury.
    2. It has the potential to aid post-workout recovery.
  1. Agmatine enhances insulin production leading to better insulin response. This allows for positive effects in attaining body composition goals. Better insulin response means a harder and leaner more muscular body.
  1. Agmatine acts on various hypothalamic and pituitary peptide hormones such as LH and GH. These will have subsequent effects on other hormones like IGF-1. Control of the hormonal environment of the athlete and you will perform better, look better and feel better.
  1. Agmatine possesses anxiolytic (relieves anxiety) and antidepressant properties offering potential control of cortisol levels in the stressful life of the athlete.
  1. Agmatine modulates nitric oxide (NO) through different ways. It stimulates some types of nitric oxide synthase (NOS) while inhibiting others. This is essential to the proper functioning of the polyamine biosynthetic pathways.
  1. Agmatine acts oncatecholamine (Epinephrine > Norepinephrine > Dopamine) release. These endogenous compounds are part of nearly every action in the body. Most notably for the athlete is the role that this compound would ultimately have in both energy production and aiding anticipation of the stressafforded by competition. However, there are also well-established roles that epinephrine can have on the body that includes:
  1. Agmatine has an antioxidant role. There can be no greater source of free-radical build up than that seen in the day-to-day activity of the athlete. The sheer stress that the body takes on when in you’re an athlete in the trenches (i.e. – the gym, the field, etc…) could ultimately have significant detrimental effects with continued build up. Agmatine can offer protection from the undesired effects that free radicals can have on the body.
  1. For the athlete desiring body composition change, Agmatine has an independent role of insulin and testosterone management on lipid (fat) metabolism.
  2. Agmatine possesses nootropic effects (it acts as a “novel” neurotransmitter). This can offer the athlete a potential mental edge to prepare for various events.
  3. Agmatine can aid in kidney function by stimulating the glomerular filtration rate (GFR). This can bode the bodybuilder well as various nitrogenous waste products are removed through this system.
  4. Agmatine harbors a hypotensive role which could assist the exogenously-enhanced athlete in keeping blood pressure in check.

My training and diet system is available customised for your body and goals. You can signup through this link: https://gertlouw.com/my-transformation-secrets/

 

POST-WORKOUT – IMMEDIATELY after training:

Apple or banana to recover lost energy consumption

L-Glutamine 5g to 8g dissolved in water

Because of the risk of your body’s L-glutamine reserves that dropped during training too low, you IMMEDIATELY must replenish with L-Glutamine after training to ensure your body stays in an anabolic environment.

Remember if you do not do this, it might take up to 6 days of a catabolic environment with no muscle growth despite all your hard work on diet and training.

WHEY protein  – quick absorption 40g mixed in water (together with L-Glutamine)

Your muscles need the right building blocks to recover exercise induced damage and the quicker you feed your body with quick absoption whey protein after training the quicker it can start repairing and building.

Other supplements that might be considered:

Creatine

Creatine might be beneficial for certain individuals. However, for a certain percentage of people creatine have absolutely no effect. Unfortunately I am one of them.

The second reason I am not using it is that it tends to let one look a little bloated, especially when you are trying to cut.

Anti Oxidants (alpha lipoic acid, Co Enzyme Q10, Saw Palmetto)

New research seems to indicate that it might not be such a good idea to take anti-oxidants straight before or after training. It suggests that it must be taken as far removed from training as possible. If taken close to training it seems to be counter productive to a fatloss environment.

Whether you believe that or not, it might be a good idea to consider it. There seems to be rather solid science behind it.

Alpha lipoic acid (about 400mg twice daily) helps regulate your insulin levels which means a better fat-loss environment. Plus it is a very potent anti-oxidant.Co-Enzyme Q10 (about 300mg twice daily) It assist in insulin sensitization. A problem most bodybuilders face is that with repeated insulin spikes as a result of periodically heavy carbohydrate consumption causes the body to become increasingly insulin resistant.

Insulin is probably the most powerful anabolic agents. Spiking insulin levels increase muscle protein synthesis. The Co Enzyme Q10 allows you to drive more nutrients into the     muscles. It is also extremely beneficial for a healthy heart.

Saw Palmetto (about 300mg twice daily). Helps prevent a enlarged prostate…something all guys need to be worried about and prevent!

This regime is proven and will yield great results when accompanied by focused training program and diet structured for lean growth.

Wish you all the success.

Gert Louw

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